Changes in the Hippocampal Volume and Shape in Early-Onset Mild Cognitive Impairment
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objective The aim of this study was to examine the change in the hippocampal volume and shape in early-onset mild cognitive impairment (EO-MCI) associated with the APOE ε4 carrier state. Methods This study had 50 subjects aged 55–63 years, all of whom were diagnosed with MCI at baseline via the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet. The EO-MCI patients were divided into the MCI continued (MCIcont) and Alzheimer’s disease (AD) converted (ADconv) groups 2 years later. The hippocampal volume and shape were measured for all the subjects. The local shape analysis (LSA) was used to conduct based on the 2-year-interval magnetic resonance imaging scans. Results There was a significant correlation between APOE ε4 allele and hippocampal volume atrophy. Over two years, the volume reduction in the left hippocampus was found to be faster than that in the right hippocampus, especially in the APOE ε4 carriers. LSA showed that the 2 subfields were significantly affected in the left hippocampus. Conclusion These results suggest that the possession of APOE ε4 allele may lead to greater predilection for left hippocampal atrophy in EO-MCI, and some specific subfields of the hippocampus may be more prominently involved.
Abstract
Objective The aim of this study was to examine the change in the hippocampal volume and shape in early-onset mild cognitive impairment (EO-MCI) associated with the APOE ε4 carrier state. Methods This study had 50 subjects aged 55–63 years, all of whom were diagnosed with MCI at baseline via the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet. The EO-MCI patients were divided into the MCI continued (MCIcont) and Alzheimer’s disease (AD) converted (ADconv) groups 2 years later. The hippocampal volume and shape were measured for all the subjects. The local shape analysis (LSA) was used to conduct based on the 2-year-interval magnetic resonance imaging scans. Results There was a significant correlation between APOE ε4 allele and hippocampal volume atrophy. Over two years, the volume reduction in the left hippocampus was found to be faster than that in the right hippocampus, especially in the APOE ε4 carriers. LSA showed that the 2 subfields were significantly affected in the left hippocampus. Conclusion These results suggest that the possession of APOE ε4 allele may lead to greater predilection for left hippocampal atrophy in EO-MCI, and some specific subfields of the hippocampus may be more prominently involved.
참고문헌 (40)
- Farias ST, "Progression of mild cognitive impairment to dementia in clinic- vs community-based cohorts", Arch Neurol, 66, pp.1151~1157 (2009)
- Petersen RC, "Mild cognitive impairment: ten years later", Arch Neurol, 66, pp.1447~1455 (2009)
- Apostolova LG, "Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps", Arch Neurol, 63, pp.693~699 (2006)[DOI]
- Apostolova LG, "3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI", Hum Brain Mapp, 31, pp.786~797 (2010)[DOI]
- Killiany RJ, "Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease", Ann Neurol, 47, pp.430~439 (2000)[DOI]
- Du AT, "Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease", J Neurol Neurosurg Psychiatry, 71, pp.441~447 (2001)[DOI]
- Moon SW, "Structural brain changes in early-onset Alzheimer's disease subjects using the LONI pipeline environment", J Neuroimaging, 25, pp.728~737 (2015)[DOI]
- Frisoni GB, "The clinical use of structural MRI in Alzheimer disease", Nat Rev Neurol, 6, pp.67~77 (2010)
- Tapiola T, "MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study", Neurobiol Aging, 29, pp.31~38 (2008)[DOI]
- Tanpitukpongse TP, "Alzheimer's disease neuroimaging I. Predictive utility of marketed volumetric software tools in subjects at risk for Alzheimer disease: do regions outside the hippocampus matter?", AJNR Am J Neuroradiol, 38, pp.546~552 (2017)[DOI]
- Eckerstrom C, "Small baseline volume of left hippocampus is associated with subsequent conversion of MCI into dementia: the Goteborg MCI study", J Neurol Sci, 272, pp.48~59 (2008)[DOI]
- Jack CR Jr, "Rates of hippocampal atrophy correlate with change in clinical status in aging and AD", Neurology, 55, pp.484~489 (2000)[DOI]
- Jack CR Jr, "Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD", Neurology, 62, pp.591~600 (2004)[DOI]
- Ertekin-Taner N, "Genetics of Alzheimer disease in the pre- and post-GWAS era", Alzheimers Res Ther, 2, pp.3~ (2010)[DOI]
- Pericak-Vance MA, "Identification of novel genes in late-onset Alzheimer's disease", Exp Gerontol, 35, pp.1343~1352 (2000)[DOI]
- Pievani M, "APOE4 is associated with greater atrophy of the hippocampal formation in Alzheimer's disease", Neuroimage, 55, pp.909~919 (2011)[DOI]
- Ye BS, "Neuropsychological performance and conversion to Alzheimer's disease in early- compared to late-onset amnestic mild cognitive impairment: CREDOS study", Dement Geriatr Cogn Disord, 34, pp.156~166 (2012)[DOI]
- Rossor MN, "The diagnosis of young-onset dementia", Lancet Neurol, 9, pp.793~806 (2010)[DOI]
- Frisoni GB, "The topography of grey matter involvement in early and late onset Alzheimer's disease", Brain, 130, pp.720~730 (2007)[DOI]
- Padovani A, "The usefulness of biological and neuroimaging markers for the diagnosis of early-onset Alzheimer's disease", Int J Alzheimers Dis, 2011, pp.296374~ (2011)
- Mueller SG, "Selective effect of Apo e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4 T", Neuroimage, 42, pp.42~48 (2008)[DOI]
- Moon SW, "Structural neuroimaging genetics interactions in Alzheimer's disease", J Alzheimers Dis, 48, pp.1051~1063 (2015)[DOI]
- Rosen WG, "Pathological verification of ischemic score in differentiation of dementias", Ann Neurol, 7, pp.486~488 (1980)[DOI]
- Shattuck DW, "BrainSuite: an automated cortical surface identification tool", Med Image Anal, 6, pp.129~142 (2002)[DOI]
- Jack CR Jr, "Anterior temporal lobes and hippocampal formations: normative volumetric measurements from MR images in young adults", Radiology, 172, pp.549~554 (1989)[DOI]
- Dinov I, "Neuroimaging study designs, computational analyses and data provenance using the LONI pipeline", PLoS One, 5 (2010)
- Tu Z, "Brain anatomical structure segmentation by hybrid discriminative", generative models, 2008, pp.27, 495~508
- Gutman BA, "Maximizing power to track Alzheimer's disease and MCI progression by LDA-based weighting of longitudinal ventricular surface features", Neuroimage, 70, pp.386~401 (2013)[DOI]
- Wang Y, "Surfacebased TBM boosts power to detect disease effects on the brain: an N=804 ADNI study", Neuroimage, 56, pp.1993~2010 (2011)[DOI]
- Henneman WJ, "Hippocampal atrophy rates in Alzheimer disease: added value over whole brain volume measures", Neurology, 72, pp.999~1007 (2009)[DOI]
- Jack CR Jr, "Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease", Neurology, 51, pp.993~999 (1998)[DOI]
- Apostolova LG, "Risk factors for behavioral abnormalities in mild cognitive impairment and mild Alzheimer's disease", Dement Geriatr Cogn Disord, 37, pp.315~326 (2014)[DOI]
- Sachs-Ericsson N, "Melancholia in later life: late and early onset differences in presentation, course, and dementia risk", Int J Geriatr Psychiatry, 29, pp.943~951 (2014)[DOI]
- Anstey KJ, "Characterizing mild cognitive disorders in the young-old over 8 years: prevalence, estimated incidence, stability of diagnosis, and impact on IADLs", Alzheimers Dement, 9, pp.640~648 (2013)[DOI]
- Harvey RJ, "The prevalence and causes of dementia in people under the age of 65 years", J Neurol Neurosurg Psychiatry, 74, pp.1206~1209 (2003)[DOI]
- Morris JC, "Early-stage and preclinical Alzheimer disease", Alzheimer Dis Assoc Disord, 19, pp.163~165 (2005)[DOI]
- Frisoni GB, "In vivo neuropathology of the hippocampal formation in AD: a radial mapping MR-based study", Neuroimage, 32, pp.104~110 (2006)[DOI]
- Frisoni GB, "Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla", Brain, 131, pp.3266~3276 (2008)[DOI]
- Risacher SL, "Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort", Curr Alzheimer Res, 6, pp.347~361 (2009)[DOI]
- Shi J, "Genetic influence of apolipoprotein E4 genotype on hippocampal morphometry: an N=725 surface-based Alzheimer's disease neuroimaging initiative study", Hum Brain Mapp, 35, pp.3903~3918 (2014)[DOI]
