본문 바로가기
KERD
논문KCI 등재

조현병 환자에서 성기능 장애의 유병률과 양상에 관한 대조군 비교 연구

The Comparison of Prevalence and Patterns of Sexual Dysfunction between Patients with Schizophrenia and Healthy Controls

최진혁|이경환|제영묘|장세헌|백대업|윤지환
대한생물치료정신의학회 (Korean Society Of Biological Therapies In Psychiatry)|2021.06|생물치료정신의학 (Journal of the Korean Society of Biological Therapies in Psychiatry)|제27권 제2호|pp. 112-123|DOI 10.22802/jksbtp.2021.27.2.112

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

조현병SchizophreniaPhysiological항정신병약물Antipsychotics생리적 성기능 장애성별에 따른 차이Sexual dysfunctionSex difference
주제분류정신과학

초록

Objectives：Sexual dysfunction is common in both untreated and treated patients with schizophrenia and known as affecting the quality of life and drug compliance. The primary objective of this study is to estimate the prevalence of sexual dysfunction in Korean patients with schizophrenia treated with antipsychotic medications compared with healthy controls. Methods：Subjects were 75 patients who were recruited from outpatients with a diagnosis of schizophrenia or schizoaffective disorder according to DSM-IV-TR criteria, who had been stabilized on antipsychotic medications for more than three consecutive months. Control group consisted of 76 volunteers without history of any psychiatric disorder were excluded. We assessed for sexual dysfunction by the ASEX. Results：The prevalence of sexual dysfunction in the patient group was 57.33%, while that of the control group was 23.37%. Female gender and the use of antidepressants were best predictors of sexual dysfunction in patient group. Sexual difference at sexual drive observed in the control group diminished in the patient group. Conclusion：The present study demonstrated a higher prevalence of sexual dysfunction in patient group than control. Clinicians should consider the differential sexual dysfunction effects of antipsychotics when prescribing medications.

Abstract

Objectives：Sexual dysfunction is common in both untreated and treated patients with schizophrenia and known as affecting the quality of life and drug compliance. The primary objective of this study is to estimate the prevalence of sexual dysfunction in Korean patients with schizophrenia treated with antipsychotic medications compared with healthy controls. Methods：Subjects were 75 patients who were recruited from outpatients with a diagnosis of schizophrenia or schizoaffective disorder according to DSM-IV-TR criteria, who had been stabilized on antipsychotic medications for more than three consecutive months. Control group consisted of 76 volunteers without history of any psychiatric disorder were excluded. We assessed for sexual dysfunction by the ASEX. Results：The prevalence of sexual dysfunction in the patient group was 57.33%, while that of the control group was 23.37%. Female gender and the use of antidepressants were best predictors of sexual dysfunction in patient group. Sexual difference at sexual drive observed in the control group diminished in the patient group. Conclusion：The present study demonstrated a higher prevalence of sexual dysfunction in patient group than control. Clinicians should consider the differential sexual dysfunction effects of antipsychotics when prescribing medications.

참고문헌 (40)

  1. Baggaley M, "Sexual dysfunction in schizophrenia: focus on recent evidence", Hum. Psychopharmacol Clin Exp, 23, pp.201~209 (2008)
  2. Aizenberg D, "Sexual dysfunction in male schizophrenia patients", J Clin Psychiatry, 56, pp.137~141 (1995)
  3. Smith SM, "Sexual dysfunction in patient taking conventional antipsychotic medication", Br J Psychiatry, 181, pp.49~55 (2002)
  4. Olfson M, "Male sexual dysfunction and quality of life in schizophrenia", J Clin Psychiatry, 66, pp.331~338 (2005)
  5. Lambert M, "Impact of present and past antipsychotic side effects on attitude toward typical antipsychotic treatment and adherence", Eur Psychiatry, 19, pp.415~422 (2004)
  6. Serretti A, "A meta-analysis of sexual dysfunction in psychiatric patients taking antipsychotics", Int Clin Psychopharmacol, 26, pp.130~140 (2011)
  7. Dossenbach M, "Prevalence of sexual dysfunction in patients with schizophrenia : international variation and underestimation", Int J Neuo psychopharmacol, 8, pp.195~201 (2005)
  8. Laumann EO, "Sexual dysfunction in the United States: prevalence and predictors", JAMA, 281, pp.537~544 (1999)
  9. Laumann EO, "Sexual problems among women and men aged 40-80 y : prevalence and correlates identified in the global study of sexual attitudes and behaviors", Int J Impot Res, 17, pp.39~57 (2005)
  10. Moreira ED, "Help-seeking behaviour for sexual problems : the global study of sexual attitudes and behaviors", Int J Clin Pract, 59, pp.6~16 (2005)
  11. Moreira ED, "Sexual activities, prevalence of sexual problems, and associated help-seeking patterns in men and women aged 40-80years in Korea: data from the global study of sexual attitudes and behaviors (GSSAB)", J Sex Med, 3, pp.201~211 (2006)
  12. Heaton JPW, "Update on central function relevant to sex : remodeling the basis of drug treatments for sex and the brain", Int J Impot Res, 15(Suppl 5), pp.S25~S32 (2003)
  13. Schwartz MF, "Hyperprolactinemia and sexual disorders in men", Biol Psychiatry, 17, pp.861~876 (1982)
  14. Haddad PM, "Antipsychotic-induced hyperprolactinemia:mechanisms, clinical features and management", Drugs, 64, pp.2291~2314 (2004)
  15. Knegtering H, "What are the effects of antipsychotics on sexual dysfunctions and endocrine functioning?", Psychoneuroendocrinology, 28(Suppl 2), pp.109~123 (2003)
  16. Mah PM, "Hyperprolactinemia: etiology, diagnosis, and management", Semin Reprod Med, 20, pp.365~374 (2002)
  17. Cutler AJ, "Sexual dysfunction and antipsychotic treatment", Psychoneuroendocrinology, 28(Suppl 1), pp.69~82 (2003)
  18. American Psychiatric Association, "Diagnostic and statistical manual of mental disorders: DSM-IV-TR" (2000), American Psychiatric Association
  19. Chow SC, "Sample size calculations in clinical research" (2007), Chapman and Hall
  20. Sharma JB, "Female sexual dysfunction : assessment", J Pak Med Assoc, 66, pp.623~626 (2016)
  21. Yafi FA, "Erectile dysfunction", Nat Rev Dis Primers, 2, pp.16003~ (2016)
  22. Ljungman L, "Sexual dysfunction and reproductive concerns in young men diagnosed with testicular cancer : an observational study", J Sex Med, 16, pp.1049~1059 (2019)
  23. Montejo AL, "Management strategies for antidepressant-related sexual dysfunction : a clinical approach", J Clin Med, 8, pp.1640~ (2019)
  24. García-Blanco A, "Sexual dysfunction and mood stabilizers in long-term stable patients with bipolar disorder", J Sex Med, 17, pp.930~940 (2020)
  25. Fujii A, "Sexual dysfunction in Japanese patients with schizophrenia treated with antipsychotics", Prog Neuropsychopharmacol Biol Psychiatry, 34, pp.288~293 (2010)
  26. Woods SW, "Chlorpromazine equivalent doses for the newer atypical antipsychotics", J Clin Psychiatry, 64, pp.663~667 (2003)
  27. McGahuey CA, "The Arizona Sexual Experience Scale(ASEX) : reliability and validation", J Sex Marital Ther, 26, pp.25~40 (2000)
  28. Guy W, "Handbook of psychiatric measures" (2008), Americap Psychiatric Association
  29. Seeman P, "Targeting the dopamine D2 receptor in schizophrenia", Expert Opin Ther Targets, 10, pp.515~531 (2006)
  30. 정선화, "항정신약물을 복용 중인 조현병 환자에서 성기능 장애의 유병률 조사", 대한조현병학회지, 19(2), pp.60~67 (2016), 대한조현병학회
  31. 송원훈, "Changes in the Prevalence and Risk Factors of Erectile Dysfunction during a Decade: The Korean Internet Sexuality Survey (KISS), a 10-Year-Interval Web-Based Survey", The World Journal of Men's Health, 37(2), pp.199~209 (2019), 대한남성과학회[DOI]
  32. Shin H, "A 10-year interval study to compare the prevalence and risk factors of female sexual dysfunction in Korea : the Korean internet sexuality survey(KISS)2014", Int J Impot Res, 29, pp.49~53 (2017)
  33. Georgiadis JR, "Functional neuroanatomy of human cortex cerebri in relation to wanting sex and having it", Clin Anat, 28, pp.314~323 (2015)
  34. Mendrek A, "Sex", gender differences in the brain and cognition in schizophrenia, 2016, pp.67, 57~78
  35. Westheide J, "Sexual dysfunction in psychiatric inpatients the role of antipsychotic medication", Pharmacopsychiatry, 40, pp.140~145 (2007)
  36. Boer MK, "The facts about sexual(dys)function in schizophrenia : an overview of clinically relevant findings", Schizophr Bull, 41(3), pp.674~684 (2015)
  37. Afe TO, "Intimate partner violence, psychopathology and the women with schizophrenia in an outpatient clinic South-South, Nigeria", BMC Psychiatry, 16, pp.197~ (2016)
  38. 강태웅, "조현병 환자의 결혼 및 성 만족도", 신경정신의학, 51(5), pp.263~270 (2012), 대한신경정신의학회
  39. Choi YT, "Review of sexual dysfunction in male schizophrenics", J Korean Soc Biol Psychiatry, 7, pp.85~98 (2000)
  40. Torniainen M, "Sex differences in cognition among persons with schizophrenia and healthy first-degree relatives", Psychiatry Res, 188, pp.7~12 (2011)

관련 논문AI추천

항정신약물을 복용 중인 조현병 환자에서 성기능 장애의 유병률 조사강시현, 박동연, 박은경, 윤해주, 이종일, 정선화대한조현병학회 · 대한조현병학회지2016 · 제19권 제2호항정신병약물을 복용중인 정신분열병 환자에서 고프로락틴혈증과 무월경 유병률 및 성기능 장애와 관련성강권영, 강시현, 김경훈, 김권곤, 소민아, 안길준, 이가희, 이종일대한신경정신의학회 · 신경정신의학2009 · 제48권 제6호조현병 환자의 결혼 및 성 만족도강권영, 강태웅, 노성원, 한혜리대한신경정신의학회 · 신경정신의학2012 · 제51권 제5호Sexuality and Quality of Life in Eastern Taiwan People With SchizophreniaJian-Kang Chao, Mei Hua Chung, Mi Chia Ma, Ru Wei Lin대한신경정신의학회 · PSYCHIATRY INVESTIGATION2023 · 제20권 제1호항정신병약물로 유발된 고프로락틴혈증을 가진 조현병 환자의 삶의 질우선진, 원승희, 진보현대한생물치료정신의학회 · 생물치료정신의학2018 · 제24권 제3호Assessment of the Latent Adverse Events of Antipsychotic Treatment Using a Subjective Questionnaire in Japanese Patients with SchizophreniaAzusa Kato, Hiroyuki Kamei, Ippei Takeuchi, Junji Uno, Kiyoshi Fujita, Manako Hanya, Masakazu Hatano, Nakao Iwata, Shigeki Yamada대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2017 · 제15권 제2호

이 간행물의 다른 논문 (3건)

졸피뎀 유발 복합 수면 행동이지민, 장성만pp. 89-96월경주기에서의 호르몬의 변화가 뇌에 미치는 영향: 구조 및 기능적 자기공명영상 연구를 중심으로윤수정, 김정윤, 송유미, 하은지pp. 97-111범죄를 저지른 조현병 스펙트럼 장애 환자의 바이브라이미지(Vibraimage) 특성임경옥, 이태섭, 차승민, 장소영, 한송이, 조성남pp. 124-130
원문 보기