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항정신병약물을 복용중인 정신분열병 환자에서 고프로락틴혈증과 무월경 유병률 및 성기능 장애와 관련성

The Prevalence of Hyperprolactinemia and Amenorrhea and the Association with Sexual Dysfunction in Schizophrenic Patients with Antipsychotics

김경훈|소민아|이종일|강시현|강권영|김권곤|안길준|이가희
대한신경정신의학회 (Korean Neuropsychiatric Association)|2009.12|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제48권 제6호|pp. 422-428

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참고문헌

키워드

고프로락틴혈증·무월경·항정신병약물·정신분열병·성기능장애Hyperprolactinemia·Amenorrhea·Antipsychotics·Schizophrenia·Sexual dysfuncion
주제분류정신과학

초록

본 연구는 실제 임상 환경에서 동일한 항정신병약물을 1년 이상 복용 중인 정신분열병 및 분열정동장애 환자들을 대상으로 고프로락틴혈증 및 무월경 유병률을 조사하고, 고프로락틴혈증과 주관적인 성기능 장애 및 무월경과의 관련성을 살펴보았다. 고프로락틴혈증의 유병률은 52.3%, 무월경 유병률은 21.5%로 결코 낮지 않았다. 항정신병약물에 의한 고프로락틴혈증이 주관적인 성기능 장애에 유의한 영 향을 미치지 않았으나 무월경과는 유의한 관련성이 있었다. 아직도 임상에서 고프로락틴혈증 및 이와 관련된 부작용에 대한 적극적인 관심과 평가가 필요하다.

Abstract

Objectives: Many antipsychotics are associated with hyperprolactinemia and sexual dysfunction. This study investigated the prevalence of hyperprolactinemia and amenorrhea and explored the association between hyperprolactinemia and sexual dysfunction. Methods: We analyzed 285 patients with schizophrenia or schizoaffective disorder who had been taking antipsychotics more than one year, examining their serum prolactin levels and administering the Arizona Sexual Experience Scale (ASEX) to evaluate for sexual dysfunction. We conducted an ANCOVA to evaluate the effect of hyperprolactinemia on ASEX score and amenorrhea. Results: We found hyperprolactinemia in 52.3% of the patients, finding it to be more common in females (60.8%) than in males (49%). Patients taking risperidone had the highest prevalence of hyperprolactinemia (86.5%), and patients taking aripiprazole showed no hyperprolactinemia. Amenorrhea prevalence was 21.5%. Hyperprolactinemia did not significantly affect ASEX scores, but it significantly affected amenorrhea. Conclusion: Many patients taking antipsychotics still experience hyperprolactinemia in a real clinical setting. The prevalence of hyperprolactinemia varies among antipsychotics. Clinicians should consider the possibility of antipsychotic-induced hyperprolactinemia, with its potential adverse effects, when treating such patients.

참고문헌 (35)

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