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항정신약물을 복용 중인 조현병 환자에서 성기능 장애의 유병률 조사

Prevalence of Sexual Dysfunction in Schizophrenic Patients Taking Antipsychotic Drugs

박은경|이종일|강시현|박동연|윤해주|정선화
대한조현병학회 (Korean Academy of Schizophrenia)|2016.10|대한조현병학회지 (Korean Journal of Schizophrenia Research)|제19권 제2호|pp. 60-67

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참고문헌

키워드

조현병Schizophrenia항정신병약물Sexual dysfunction성기능 장애Antipsychotic agent
주제분류정신과학

초록

Objectives : Sexual dysfunction is said to affect the compliance of drug and quality of life. This study is a research to investigate the prevalence of sexual dysfunction and affecting factors that can occur when schizophrenic and schizoaffective patients have taken drugs. Methods : Subjects were 300 patients who have been taken inpatient or outpatient treatment in national seoul hospital. We used UKU-S, ASEX scale for evaluating the prevalence of sexual dysfunction and CGI-S, PANSS negative scale and CES-D for investigating the influence of psychopathology and depressive symptoms on sexual dysfunction. Results : It was reported sexual dysfunction 82.7% in male and 92.2% in female with 7 items of UKU-S. The prevalence of sexual dysfunction with criteria of ASEX was 47.72% in male and 65.05% in female. Sexual dysfunction was more prevalent in patients taking prolactin-elevation drugs. In the factor analysis for the sexual dysfunction it was investigated that age, onset time, CGI-S, PANSS negative scale, and CES-D can affect the sexual dysfunction in both male and female. Conclusion : This study reported that many patients complained of sexual dysfunction. On considering the influence of sexual dysfunction to compliance and quality of life, clinicians evaluate sexual side effects more actively because patients are more likely not spontaneously tell the sexual side effects in comparison to others.

Abstract

Objectives : Sexual dysfunction is said to affect the compliance of drug and quality of life. This study is a research to investigate the prevalence of sexual dysfunction and affecting factors that can occur when schizophrenic and schizoaffective patients have taken drugs. Methods : Subjects were 300 patients who have been taken inpatient or outpatient treatment in national seoul hospital. We used UKU-S, ASEX scale for evaluating the prevalence of sexual dysfunction and CGI-S, PANSS negative scale and CES-D for investigating the influence of psychopathology and depressive symptoms on sexual dysfunction. Results : It was reported sexual dysfunction 82.7% in male and 92.2% in female with 7 items of UKU-S. The prevalence of sexual dysfunction with criteria of ASEX was 47.72% in male and 65.05% in female. Sexual dysfunction was more prevalent in patients taking prolactin-elevation drugs. In the factor analysis for the sexual dysfunction it was investigated that age, onset time, CGI-S, PANSS negative scale, and CES-D can affect the sexual dysfunction in both male and female. Conclusion : This study reported that many patients complained of sexual dysfunction. On considering the influence of sexual dysfunction to compliance and quality of life, clinicians evaluate sexual side effects more actively because patients are more likely not spontaneously tell the sexual side effects in comparison to others.

참고문헌 (37)

  1. McCabe MP, "Risk factors for sexual dysfunction among women and men:a consensus statement from the fourth international consultation on sexual medicine 2015", Journal of Sexual Medicine, 13, pp.153~167 (2016)
  2. Fric M, "Prolactin levels and symptoms of hyperprolactinaemia in patients treated with amisulpride, risperidone, olanzapine and quetiapine", Psychiatr Prax, 30, pp.97~101 (2003)
  3. Smith SM, "Sexual dysfunction in patients taking conventional antipsychotic medication", Br J Psychiatry, 181, pp.49~55 (2002)
  4. Richard GP, "Prolactin and antipsychotic medications: mechanism of action", Schizophr Res, 35, pp.67~73 (1999)
  5. Compton MT, "Antipsychotic-induced hyperprolactinemia and sexual dysfunction", Psychopharmacol Bull, 36, pp.143~164 (2001)
  6. Yasui-Furukori N, "No association between hormonal abnormality and sexual dysfunction in Japanese schizophrenia patients treated with antipsychotics", Hum Psychopharmacol, 27, pp.82~89 (2012)
  7. Dossenbach M, "Prevalence of sexual dysfunction in patients with schizophrenia: international variation and underestimation", Int J Neuropsychopharmacol, 8, pp.195~201 (2005)
  8. Uçok A, "Sexual dysfunction in patients with schizophrenia on antipsychotic medication", Eur Psychiatry, 22, pp.328~333 (2007)
  9. Fujii A, "Sexual dysfunction in Japanese patients with schizophrenia treated with antipsychotics", Prog Neuropsychopharmacol Biol Psychiatry, 34, pp.288~293 (2010)
  10. Choi YT, "Review of sexual dysfunction in male schizophrenics", J Korean Soc Biol Psychiatry, 7, pp.85~98 (2000)
  11. 이가희, "항정신병약물을 복용중인 정신분열병 환자에서 고프로락틴혈증과 무월경 유병률 및 성기능 장애와 관련성", 신경정신의학, 48(6), pp.422~428 (2009), 대한신경정신의학회
  12. Olfson M, "Male sexual dysfunction and quality of life in schizophrenia", J Clin Psychiatry, 66, pp.331~338 (2005)
  13. Costa AM, "A systematic review on clinical management of antipsychotic-induced sexual dysfunction in schizophrenia", Sao Paulo Med J, 124, pp.291~297 (2006)
  14. American Psychiatric Association, "Diagnostic and statistical manual of mental disorders: DSM-IV-TR" (2000), American Psychiatric Association
  15. Byerly M, "Clinical implications of antipsychotic-induced hyperprolactinemia in patients with schizophrenia spectrum or bipolar spectrum disorders: recent developments and current perspectives", J Clin Psychopharmacol, 27, pp.639~661 (2007)
  16. Kane JM, "Aripiprazole for treatment-resistant schizophrenia: results of a multicenter, randomized, double-blind, comparison study versus perphenazine", J Clin Psychiatry, 68, pp.213~223 (2007)
  17. Tauscher-Wisniewski S, "Quetiapine: an effective antipsychotic in first-episode schizophrenia despite only transiently high dopamine-2 receptor blockade", J Clin Psychiatry, 63, pp.992~997 (2002)
  18. Bushe C, "Categorical prevalence and severity of hyperprolactinaemia in two UK cohorts of patients with severe mental illness during treatment with antipsychotics", J Psychopharmacol, 22, pp.56~62 (2008)
  19. Crawford AM, "The acute and longterm effect of olanzapine compared with placebo and haloperidol on serum prolactin concentrations", Schizophr Res, 26, pp.41~54 (1997)
  20. Woods SW, "Chlorpromazine equivalent doses for the newer atypical antipsychotics", J Clin Psychiatry, 64, pp.663~667 (1899)
  21. Harrison WM, "Effects of antidepressant medication on sexual function:a controlled study", J Clin Psychopharmacol, 6, pp.144~149 (1986)
  22. Montejo AL, "Incidence of sexual dysfunction associated with antidepressant agents:a prospective multicenter study of 1022 outpatients", J Clin Psychiatry, 62, pp.10~21 (2001)
  23. Guy W, "Psychiatric Measures" (2000), APA
  24. Kay SR, "The positive and negative syndrome scale (PANSS) for schizophrenia", Schizophr Bull, 13, pp.261~276 (1987)
  25. Radloff LS, "The CES-D scale: a self-report depression scale for research in the general population", Applied Psychological Measurement, 1, pp.385~401 (1977)
  26. McGahuey CA, "The Arizona Sexual Experience Scale (ASEX): reliability and validity", J Sex Marital Ther, 26, pp.25~40 (2000)
  27. Martha S, "Rating scales in mental health", pp.376~378 (2006), Lexi-comp
  28. Lingjaerde O, "The UKU side effect rating scale: a new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients", Acta Psychiatr Scand, 76, pp.1~100 (1987)
  29. Schwartz MF, "Hyperprolactinemia and sexual disorders in men", Biol Psychiatry, 17, pp.861~876 (1982)
  30. Mah PM, "Hyperprolactinemia: etiology, diagnosis, and management", Semin Reprod Med, 20, pp.365~374 (2002)
  31. Westheide J, "Sexual dysfunction in psychiatric inpatients the role of antipsychotic medication", Pharmacopsychiatry, 40, pp.140~145 (2007)
  32. Harley EW, "Sexual problems in schizophrenia:prevalence and characteristics. A cross sectional survey", Soc Psychiatry Psychiatr Epidemiol, 45, pp.759~766 (2010)
  33. Rettenbacher MA, "Prolactin levels and sexual adverse effects in patients with schizophrenia during antipsychotic treatment", J Clin Psychopharmacol, 30, pp.711~715 (2010)
  34. Smith S, "Sexual dysfunction-the forgotten taboo", Mental Health Nurs, 25, pp.6~9 (2005)
  35. Gopalakrishnan R, "Sildenafil in the treatment of antipsychotic-induced erectile dysfunction: a randomized, double-blind, placebo-controlled, flexible-dose, two-way crossover trial", Am J Psychiatry, 163, pp.494~499 (2006)
  36. Seeman MV, "Loss of libido in a woman with schizophrenia", Am J Psychiatry, 170, pp.471~475 (2013)
  37. Hou CL, "Sexual dysfunction and its impact on quality of life in Chinese patients with schizophrenia treated in primary care", Comprehensive Psychiatry, 65, pp.116~121 (2016)

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