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βTC-6 세포에서 Fluoxetine과 Mirtazapine이 인슐린 분비에 미치는 영향

Effects of Fluoxetine and Mirtazapine on Insulin Secretion in βTC-6 Cells

이건일|전성균|박기창|장형민|공인덕
대한생물치료정신의학회 (Korean Society Of Biological Therapies In Psychiatry)|2004.12|생물치료정신의학 (Journal of the Korean Society of Biological Therapies in Psychiatry)|제10권 제2호|pp. 162-171

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키워드

Fluoxetine·Mirtazapine·βTC-6·인슐린.FluoxetineMirtazapineβTC-6Insulin.
주제분류정신과학

초록

목 적： 우울증이 동반된 당뇨병환자에게 항우울제를 투여하면 우울증상의 재발을 막는 것은 물론이고 혈당조절에도 도움이 된다고 알려져 있다. 그러나, 최근 연구들은 TCA계 항우울제가 혈당을 악화시킨다고 하고, SRI계 약물들에 대해서는 연구자마다 다른 결과를 보고하고 있다. 본 연구는 SRI계 대표적 약물인 fluoxetine과, 고혈당증을 유발한 것으로 최근 국내에서 보고된 mir -tazapine이 췌장 β세포의 인슐린 분비에 어떠한 영향을 미치는 지를 알아보고자 하였다. 방 법： 마우스의 췌장 β 세포주인 βTC-6를 대상으로 fluo -xetine과 mirtazapine을 투여하여 인슐린 분비에 미치는 영향을 관찰하였다. βTC-6 세포를 2시간의 정적 배양 후 방사면역법을 이용하여 인슐린 분비를 측정하였다.

Abstract

Objective : It is well known that antidepressants improve glycemic control and prevent relapse of depression in diabetics. However, TCA antidepressants directly interfere with blood glucose levels in some recent reports, and the effects of SSRI antidepressants on blood glucose are controversial. This study aimed to explore the effects of fluoxetine and mirtazapine on insulin secretion. Methods : This study investigated the effect of fluoxetine and mirtazapine on insulin secretion in βTC-6 cells - mouse pancreatic β cell line. Fluoxetine is a prototype of SSRI, mirtazapine is a NaSSA, both of them are widely prescribed. After static incubation during 2 hours, insulin secretion was measured by radioimmunoassay. Results : 1) Glucose increased insulin secretion in a concentration-dependent manner with EC50 2.7 ± 0.3 mM. 2) As the number of cell increased, the amount of insulin secretion was significantly increased. 3) Glibenclamide, KATP-channel blocker, markedly increased insulin release. 4) Fluoxetine and mirtazapine inhibited insulin secretion at low(1 μM) and high(10 μM) concentration. 5) The inhibitory effects of fluoxetine(10 μM) were significantly greater than those of mirtazapine(10 μM). 6) These inhibitory effects of fluoxetine and mirtazapine on insulin secretion were significantly greater in high glucose level than in low glucose level. Conclusion : Taken together, fluoxetine and mirtazapine might inhibit insulin secretion directly in βTC-6 Cells.

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