항우울제의 사용과 체중
Usage of Antidepressants and Weight
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Depressive disorder is a very common disease, clinical manifestations vary, and the mechanism is not clear. Therefore, a pharmacotherapy is very important to achieve sufficient therapeutic effect, but the choice of drug is not easy due to the occurrence of side effects of treatment and confusion with clinical features. It is easy to overlook the side effects of weight gain with antidepressants compared with antipsychotics, but they are frequently observed in clinical settings. The first-generation antidepressants have higher weight gains than selective serotonin reuptake inhibitors. Serotonin norepinephrine reuptake inhibitors are observed to have less weight gain, and dopamine norepinephrine reuptake inhibitors have weight loss effect due to decreased appetite. Mirtazapine, an atypical antidepressant, has a strong histamine H1 blockade, and gains weight gain from short-term use. The effects of desvenlafaxine, vortioxetine, and agomelatin on weight, which have recently been increasing in use, have not been largely identified. For better compliance, studies on weight gain due to the use of antidepressants are needed.
Abstract
Depressive disorder is a very common disease, clinical manifestations vary, and the mechanism is not clear. Therefore, a pharmacotherapy is very important to achieve sufficient therapeutic effect, but the choice of drug is not easy due to the occurrence of side effects of treatment and confusion with clinical features. It is easy to overlook the side effects of weight gain with antidepressants compared with antipsychotics, but they are frequently observed in clinical settings. The first-generation antidepressants have higher weight gains than selective serotonin reuptake inhibitors. Serotonin norepinephrine reuptake inhibitors are observed to have less weight gain, and dopamine norepinephrine reuptake inhibitors have weight loss effect due to decreased appetite. Mirtazapine, an atypical antidepressant, has a strong histamine H1 blockade, and gains weight gain from short-term use. The effects of desvenlafaxine, vortioxetine, and agomelatin on weight, which have recently been increasing in use, have not been largely identified. For better compliance, studies on weight gain due to the use of antidepressants are needed.
참고문헌 (57)
- Andrade L, "The epidemiology of major depressive episodes : results from the International Consortium of Psychiatric Epidemiology(ICPE)Surveys", Int J Methods Psychiatr Res, 12, pp.3~21 (2003)
- Robins LN, "Psychiatric Disorders in America: The Epidemiologic Catchment Area Study" (1991), The Free Press
- 조맹제, "한국 주요정신장애의 유병률 및 관련요인:2006 전국정신질환역학조사", 신경정신의학, 48(3), pp.143~152 (2009), 대한신경정신의학회
- Korean Neuropsychiatric Association, "Textbook of Neuropsychiatry" (2017), iMiS Company
- 송후림, "신경염증과 정신질환", 생물정신의학, 23(1), pp.12~17 (2016), 대한생물정신의학회
- Leonard BE, "Impact of inflammation on neurotransmitter changes in major depression : an insight into the action of antidepressants", Prog Neuropsychopharmacol Biol Psychiatry, 48, pp.261~267 (2014)
- Hillhouse TM, "A brief history of the development of antidepressant drugs : from monoamines to glutamate", Exp Clin Psychopharmacol, 23, pp.1~21 (2015)
- Papakostas GI, "Towards new mechanisms : an update on therapeutics for treatment-resistant major depressive disorder", Mol Psychiatry, 20, pp.1142~1150 (2015)
- Weilburg JB, "An overview of SSRI and SNRI therapies for depression", Manag Care, 13, pp.25~33 (2004)
- Benjamin S, "Review of the use of mirtazapine in the treatment of depression", Expert Opin Pharmacother, 12, pp.1623~1632 (2011)
- Fava M, "Augmentation and combination strategies in treatment-resistant depression", J Clin Psychiatry, 62(Suppl 18), pp.4~11 (2001)
- Fava M, "Diagnosis and definition of treatment-resistant depression", Biol Psychiatry, 53, pp.649~659 (2003)
- Nierenberg AA, "Treatment-resistant bipolar depression : a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone", Am J Psychiatry, 163, pp.210~216 (2006)
- Bahk WM, "Textbook of depressive disorders" (2012), Sigma press
- 정희정, "새로운 우울증 치료 약물", 생물정신의학, 23(1), pp.1~11 (2016), 대한생물정신의학회
- Fava M, "Weight gain and antidepressants", J Clin Psychiatry, 61(Suppl 11), pp.37~41 (2000)
- Diagnostic and statistical manual of mental disorders: DSM-5, "American Psychiatric Association", American Psychaitric Association, ~ (2013)
- Pan A, "Bidirectional association between depression and metabolic syndrome : a systematic review and meta-analysis of epidemiological studies", Diabetes Care, 35, pp.1171~1180 (2012)
- Cho SJ, "The relationship between visceral adiposity and depressive symptoms in the general Korean population", J Affect Disord, 244, pp.54~59 (2019)
- Grundy SM, "Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute", American Heart Association conference on scientific issues related to definition, 2004, pp.24, e13~e18
- Assari S, "Gender and Ethnic Differences in the association between obesity and depression among black adolescents", J Racial Ethn Health Disparities, 2, pp.481~493 (2015)
- de Jonghe F, "A randomized, doubleblind study of fluoxetine and maprotiline in the treatment of major depression", Pharmacopsychiatry, 24, pp.62~67 (1991)
- Michelson D, "Changes in weight during a 1-year trial of fluoxetine", Am J Psychiatry, 156, pp.1170~1176 (1999)
- Croft H, "A placebo-controlled comparison of the antidepressant efficacy and effects on sexual functioning of sustained-release bupropion and sertraline", Clin Ther, 21, pp.643~658 (1999)
- Moon CA, "The effects of psychomotor performance of fluvoxamine versus mianserin in depressed patients in general practice", Br J Clin Pract, 45, pp.259~262 (1991)
- Shi Z, "SSRI antidepressant use potentiates weight gain in the context of unhealthy lifestyles : results from a 4-year Australian follow-up study", BMJ Open, 7, pp.e016224~ (2017)
- Fava M, "Fluoxetine versus sertraline and paroxetine in major depressive disorder : changes in weight with long-term treatment", J Clin Psychiatry, 61, pp.863~867 (2000)
- Aberg-Wistedt A, "Sertraline versus paroxetine in major depression : clinical outcome after six months of continuous therapy", J Clin Psychopharmacol, 20, pp.645~652 (2000)
- Silverstone PH, "Once-daily venlafaxine extended release(XR)compared with fluoxetine in outpatients with depression and anxiety. Venlafaxine XR 360 Study Group", J Clin Psychiatry, 60, pp.22~28 (1999)
- Gafoor R, "Antidepressant utilisation and incidence of weight gain during 10 years’ follow-up: population based cohort study", BMJ, 361, pp.k1951~ (2018)
- Alam MY, "Safety, tolerability, and efficacy of vortioxetine(Lu AA21004)in major depressive disorder : results of an open-label, flexible-dose, 52-week extension study", Int Clin Psychopharmacol, 29, pp.36~44 (2014)
- Tourian KA, "Desvenlafaxine and weight change in major depressive disorder", Prim Care Companion J Clin Psychiatry, 12, pp.e1~e8 (2010)
- Harto-Truax N, "Effects of bupropion on body weight", J Clin Psychiatry, 44, pp.183~186 (1983)
- Smith WT, "Mirtazapine vs. amitriptyline vs. placebo in the treatment of major depressive disorder", Psychopharmacol Bull, 26, pp.191~196 (1990)
- Cho SJ, "Mirtazapine augmentation enhances cognitive and reduces negative symptoms in schizophrenia patients treated with risperidone: a randomized controlled trial", Prog Neuropsychopharmacol Biol Psychiatry, 35, pp.208~211 (2011)
- Jieun Lee, "The Tolerability of Mirtazapine Augmentation in Schizophrenic Patients Treated with Risperidone: A Preliminary Randomized Placebo-controlled Trial", Clinical Psychopharmacology and Neuroscience, 9(2), pp.73~77 (2011), 대한정신약물학회
- Montgomery SA, "Mirtazapine versus amitriptyline in the long-term treatment of depression : a double-blind placebo-controlled study", Int Clin Psychopharmacol, 13, pp.63~73 (1998)
- Goodnick PJ, "Weight change during mirtazapine therapy", Prim Psychiatry, 3, pp.103~108 (1998)
- Caffey EM Jr, "Side effects and laboratory findings in a study of anti-depressant drugs", Dis Nerv Syst, 23, pp.444~449 (1962)
- Fernstrom MH, "Antidepressant-induced weight gain : a comparison study of four medications", Psychiatry Res, 26, pp.265~271 (1988)
- Garland EJ, "Weight gain with antidepressants and lithium", J Clin Psychopharmacol, 8, pp.323~330 (1988)
- Frank E, "Imipramine and weight gain during the treatment of recurrent depression", J Affect Disord, 20, pp.165~172 (1990)
- Frank E, "Imipramine and weight gain during the long-term treatment of recurrent depression", J Affect Disord, 26, pp.65~72 (1992)
- Feiger AD, "Double-blind, placebo-substitution study of nefazodone in the prevention of relapse during continuation treatment of outpatients with major depression", Int Clin Psychopharmacol, 14, pp.19~28 (1999)
- Sussman N, "Effects of psychotropic drugs on weight", Psychiatr Ann, 29, pp.580~594 (1999)
- Guaiana G, "Agomelatine versus other antidepressive agents for major depression", Cochrane Database Syst Rev, pp.CD008851~ (2013)
- Berken GH, "Weight gain. A side-effect of tricyclic antidepressants", J Affect Disord, 7, pp.133~138 (1984)
- Benazzi F, "Weight gain in depression remitted with antidepressants : pharmacological or recovery effect", Psychother Psychosom, 67, pp.271~274 (1998)
- Fernstrom MH, "Imipramine treatment and preference for sweets", Appetite, 10, pp.149~155 (1988)
- Levitt AJ, "The effect of desipramine on body weight in depression", J Clin Psychiatry, 48, pp.27~28 (1987)
- Bouwer CD, "Phasic craving for carbohydrate observed with citalopram", Int Clin Psychopharmacol, 11, pp.273~278 (1996)
- Wright DE, "Comparative localization of serotonin1A, 1C, and 2 receptor subtype mRNAs in rat brain", J Comp Neurol, 351, pp.357~373 (1995)
- Hoffman BJ, "Distribution of serotonin 5-HT1C receptor mRNA in adult rat brain", FEBS Lett, 247, pp.453~462 (1989)
- Britton DR, "Intraventricular corticotropin-releasing factor enhances behavioral effects of novelty", Life Sci, 31, pp.363~367 (1982)
- Levine AS, "Effect of centrally administered corticotropin releasing factor(CRF)on multiple feeding paradigms", Neuropharmacology, 22, pp.337~339 (1983)
- Pijl H, "Effect of serotonin re-uptake inhibition by fluoxetine on body weight and spontaneous food choice in obesity", Int J Obes, 15, pp.237~242 (1991)
- Fernstrom MH, "Depression, antidepressants, and body weight change", Ann N Y Acad Sci, 575, pp.31~39 (1989)
