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DSM-5 신경인지장애의 아형에 따른 신경인지기능의 특성 및 아형별 중증도에 영향을 미치는 인자

Characteristics of Neurocognitive Function and Factors Affecting the Severity of Neurocognitive Disorders Classified according to Subtypes

구본훈|배대석|서완석|이동엽|이영지|김혜금|이승우|천은진
대한생물치료정신의학회 (Korean Society Of Biological Therapies In Psychiatry)|2016.10|생물치료정신의학 (Journal of the Korean Society of Biological Therapies in Psychiatry)|제22권 제3호|pp. 196-208

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참고문헌

키워드

Vascular dementia알츠하이머 병Alzheimer disease신경인지장애혈관성 치 매외상성 뇌 손상.Neurocognitive disorderTraumatic brain injury
주제분류정신과학

초록

Objectives：To assess differences in the cognitive function of patients with neurocognitive disorders, and to investigate cognitive tests that affect the severity classification of neurocognitive disorders. Methods：We retrospectively examined 207 patients diagnosed as having a neurocognitive disorder due to Alzheimer disease(AD), vascular neurocognitive disorder(VD), or neurocognitive disorder due to traumatic brain injury (TBI), per the Diagnostic and Statistical Manual of Mental Disorders, fifth edition(DSM-5). We administered the Seoul Neuropsychological Screening Battery, second edition. Patients were classified into major and mild neurocognitive disorder groups according to the DSM-5 diagnostic criteria and clinical dementia rating score. Results：The major VD group exhibited greater impairment on attention function, language function, visuospatial function, and frontal and executive function than the major AD group. The major TBI group exhibited greater impairment on language function, memory function, and frontal and executive function than the major AD group. The mild VD group exhibited greater impairment on visuospatial function, and frontal and executive function than the mild AD group. Results of logistic regression analyses showed that the Korean-Boston Naming Test and memory function tests affected the severity classification of neurocognitive disorders. Conclusion：Despite our study’s limitations, the VD and TBI groups exhibited greater impairment on overall neurocognitive function than the AD group. Additionally, the Korean-Boston Naming Test and memory function tests can significantly affect the severity classification of neurocognitive disorders.

Abstract

Objectives：To assess differences in the cognitive function of patients with neurocognitive disorders, and to investigate cognitive tests that affect the severity classification of neurocognitive disorders. Methods：We retrospectively examined 207 patients diagnosed as having a neurocognitive disorder due to Alzheimer disease(AD), vascular neurocognitive disorder(VD), or neurocognitive disorder due to traumatic brain injury (TBI), per the Diagnostic and Statistical Manual of Mental Disorders, fifth edition(DSM-5). We administered the Seoul Neuropsychological Screening Battery, second edition. Patients were classified into major and mild neurocognitive disorder groups according to the DSM-5 diagnostic criteria and clinical dementia rating score. Results：The major VD group exhibited greater impairment on attention function, language function, visuospatial function, and frontal and executive function than the major AD group. The major TBI group exhibited greater impairment on language function, memory function, and frontal and executive function than the major AD group. The mild VD group exhibited greater impairment on visuospatial function, and frontal and executive function than the mild AD group. Results of logistic regression analyses showed that the Korean-Boston Naming Test and memory function tests affected the severity classification of neurocognitive disorders. Conclusion：Despite our study’s limitations, the VD and TBI groups exhibited greater impairment on overall neurocognitive function than the AD group. Additionally, the Korean-Boston Naming Test and memory function tests can significantly affect the severity classification of neurocognitive disorders.

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