메스암페타민 사용 장애에서의 의사결정 지연: 모호함에서 위험으로의 전환 지연
Decision Making Delay in Methamphetamine Use Disorder Individuals: Delayed Shift From Ambiguity to Risk
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: The aim of this study was to investigate how impaired decision-making, hypersensitivity to reward, and executive dysfunction in individuals with methamphetamine use disorder affect their ability to make decisions under uncertain conditions. Methods: We conducted a study with 33 patients diagnosed with methamphetamine use disorder and 33 healthy individuals. Three tasks were administered: the Iowa Gambling Task (IGT), Game of Dice Task (GDT), and Wisconsin Card Sorting Test (WCST). We then analyzed the participants’ performance on these tasks and calculated the correlations between them. Results: Patients with methamphetamine use disorder performed poorly on all three tasks compared to the healthy individuals. Furthermore, the correlations between performances on the GDT and the later trials of the IGT were delayed in the methamphetamine use disorder group compared to the healthy group. A strong correlations were also observed between performances on the earlier trials of the IGT and the WCST in the patient group. Conclusions: These findings suggest that executive dysfunction in individuals with methamphetamine use disorder impairs their ability to accurately estimate the probabilities of different choices. Consequently, this impairment leads to a delayed transition from uncertain to risky decisions in the IGT. The study sheds light on the neuropsychological factors that contribute to impaired decision-making under uncertainty in individuals with methamphetamine use disorder.
Abstract
Objectives: The aim of this study was to investigate how impaired decision-making, hypersensitivity to reward, and executive dysfunction in individuals with methamphetamine use disorder affect their ability to make decisions under uncertain conditions. Methods: We conducted a study with 33 patients diagnosed with methamphetamine use disorder and 33 healthy individuals. Three tasks were administered: the Iowa Gambling Task (IGT), Game of Dice Task (GDT), and Wisconsin Card Sorting Test (WCST). We then analyzed the participants’ performance on these tasks and calculated the correlations between them. Results: Patients with methamphetamine use disorder performed poorly on all three tasks compared to the healthy individuals. Furthermore, the correlations between performances on the GDT and the later trials of the IGT were delayed in the methamphetamine use disorder group compared to the healthy group. A strong correlations were also observed between performances on the earlier trials of the IGT and the WCST in the patient group. Conclusions: These findings suggest that executive dysfunction in individuals with methamphetamine use disorder impairs their ability to accurately estimate the probabilities of different choices. Consequently, this impairment leads to a delayed transition from uncertain to risky decisions in the IGT. The study sheds light on the neuropsychological factors that contribute to impaired decision-making under uncertainty in individuals with methamphetamine use disorder.
참고문헌 (53)
- Ernst M, "Neurobiology of decision making : a selective review from a neurocognitive and clinical perspective", Biol Psychiatry, 58, pp.597~604 (2005)
- Ellsberg D, "Risk, ambiguity, and the savage axioms", Q J Econ, 75, pp.643~669 (1961)
- Goel V, "Hemispheric specialization in human prefrontal cortex for resolving certain and uncertain inferences", Cereb Cortex, 17, pp.2245~2250 (2007)
- Dunn BD, "The somatic marker hypothesis : a critical evaluation", Neurosci Biobehav Rev, 30, pp.239~271 (2006)
- Verdejo-García A, "Strategic self-regulation, decision-making and emotion processing in poly-substance abusers in their first year of abstinence", Drug Alcohol Depend, 86, pp.139~146 (2007)
- Hanson KL, "Reward-related decision-making deficits and elevated impulsivity among MDMA and other drug users", Drug Alcohol Depend, 96, pp.99~110 (2008)
- Passetti F, "Neuropsychological predictors of clinical outcome in opiate addiction", Drug Alcohol Depend, 94, pp.82~91 (2008)
- Brand M, "Decision-making impairments in patients with Parkinson's disease", Behav Neurol, 15, pp.77~85 (2004)
- Hart CL, "Is cognitive functioning impaired in methamphetamine users? A critical review", Neuropsychopharmacology, 37, pp.586~608 (2012)
- Ellis C, "Everyday problems with executive dysfunction and impulsivity in adults recovering from methamphetamine addiction", Addict Disord Their Treat, 15, pp.1~5 (2016)
- Ahn SH, "The characteristics of intertemporal choice and the associated factors in methamphetamine users", J Korean Soc Biol Ther Psychiatry, 23, pp.222~229 (2017)
- Homer BD, "Methamphetamine abuse and impairment of social functioning : a review of the underlying neurophysiological causes and behavioral implications", Psychol Bull, 134, pp.301~310 (2008)
- Kim YT, "Impairments of facial emotion recognition and theory of mind in methamphetamine abusers", Psychiatry Res, 186, pp.80~84 (2011)
- van der Plas EA, "Executive control deficits in substancedependent individuals : a comparison of alcohol, cocaine, and methamphetamine and of men and women", J Clin Exp Neuropsychol, 31, pp.706~719 (2009)
- Gonzalez R, "Executive functions among individuals with methamphetamine or alcohol as drugs of choice : preliminary observations", J Clin Exp Neuropsychol, 29, pp.155~159 (2007)
- Voon V, "Risk-taking in disorders of natural and drug rewards : neural correlates and effects of probability, valence, and magnitude", Neuropsychopharmacology, 40, pp.804~812 (2015)
- Ahn WY, "Decision-making in stimulant and opiate addicts in protracted abstinence : evidence from computational modeling with pure users", Front Psychol, 5, pp.849~ (2014)
- Bischoff-Grethe A, "Altered reward expectancy in individuals with recent methamphetamine dependence", J Psychopharmacol, 31, pp.17~30 (2017)
- Wei S, "Altered neural processing of reward and punishment in women with methamphetamine use disorder", Front Psychiatry, 12, pp.692266~ (2021)
- Brand M, "Decisions under ambiguity and decisions under risk : correlations with executive functions and comparisons of two different gambling tasks with implicit and explicit rules", J Clin Exp Neuropsychol, 29, pp.86~99 (2007)
- Monterosso JR, "Deficits in response inhibition associated with chronic methamphetamine abuse", Drug Alcohol Depend, 79, pp.273~277 (2005)
- Huettel SA, "Decisions under uncertainty : probabilistic context influences activation of prefrontal and parietal cortices", J Neurosci, 25, pp.3304~3311 (2005)
- Yang T, "Probabilistic reasoning by neurons", Nature, 447, pp.1075~1080 (2007)
- Yum TH, "The manual of Korean-Wechsler adult intelligence scale" (1992), Korea Guidance
- Bechara A, "Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions", Brain, 123(Pt 11), pp.2189~2202 (2000)
- Heaton RK, "Wisconsin card sorting test manual: revised and expanded" (1993), Psychological Assessment Resources
- Breiter HC, "Functional magnetic resonance imaging of brain reward circuitry in the human", Ann N Y Acad Sci, 877, pp.523~547 (1999)
- Breiter HC, "Functional imaging of neural responses to expectancy and experience of monetary gains and losses", Neuron, 30, pp.619~639 (2001)
- Grant S, "Drug abusers show impaired performance in a laboratory test of decision making", Neuropsychologia, 38, pp.1180~1187 (2000)
- Bechara A, "Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers", Neuropsychologia, 39, pp.376~389 (2001)
- Bechara A, "Decision-making and addiction(part I) : impaired activation of somatic states in substance dependent individuals when pondering decisions with negative future consequences", Neuropsychologia, 40, pp.1675~1689 (2002)
- Kalivas PW, "The neural basis of addiction : a pathology of motivation and choice", Am J Psychiatry, 162, pp.1403~1413 (2005)
- Leland DS, "Increased risk-taking decisionmaking but not altered response to punishment in stimulant-using young adults", Drug Alcohol Depend, 78, pp.83~90 (2005)
- Hyman SE, "Neural mechanisms of addiction : the role of reward-related learning and memory", Annu Rev Neurosci, 29, pp.565~598 (2006)
- Bjork JM, "Reduced posterior mesofrontal cortex activation by risky rewards in substance-dependent patients", Drug Alcohol Depend, 95, pp.115~128 (2008)
- Gul F, "The case for mindless economics" (2005), Princeton University
- Zermatten A, "Impulsivity and decision making", J Nerv Ment Dis, 193, pp.647~650 (2005)
- erdejo-Garcia A, "The differential relationship between cocaine use and marijuana use on decision-making performance over repeat testing with the Iowa gambling task", Drug Alcohol Depend, 90, pp.2~11 (2007)
- Bechara A, "Decision-making and addiction(part II) : myopia for the future or hypersensitivity to reward?", Neuropsychologia, 40, pp.1690~1705 (2002)
- Bechara A, "Risky business : emotion, decision-making, and addiction", J Gambl Stud, 19, pp.23~51 (2003)
- MacAllister WS, "Sensitivity of the Wisconsin Card Sorting Test(64-card version)versus the Tower of London(Drexel version)for detecting executive dysfunction in children with epilepsy", Child Neuropsychol, 24, pp.354~369 (2018)
- Milner B, "Effects of different brain lesions on card sorting : the role of the frontal lobes", Arch Neurol, 9, pp.90~100 (1963)
- Corcoran R, "Schizophrenia, symptomatology and social inference : investigating"theory of mind"in people with schizophrenia", Schizophr Res, 17, pp.5~13 (1995)
- Bechara A, "The role of emotion in decision-making : evidence from neurological patients with orbitofrontal damage", Brain Cogn, 55, pp.30~40 (2004)
- Brand M, "The role of strategies in deciding advantageously in ambiguous and risky situations", Cogn Process, 9, pp.159~173 (2008)
- Rushworth MF, "Choice, uncertainty and value in prefrontal and cingulate cortex", Nat Neurosci, 11, pp.389~397 (2008)
- Noël X, "Response inhibition deficit is involved in poor decision making under risk in nonamnesic individuals with alcoholism", Neuropsychology, 21, pp.778~786 (2007)
- Gunning-Dixon FM, "Neuroanatomical correlates of selected executive functions in middle-aged and older adults : a prospective MRI study", Neuropsychologia, 41, pp.1929~1941 (2003)
- Grinband J, "A neural representation of categorization uncertainty in the human brain", Neuron, 49, pp.757~763 (2006)
- Procyk E, "Modulation of dorsolateral prefrontal delay activity during self-organized behavior", J Neurosci, 26, pp.11313~11323 (2006)
- Seeley WW, "Dissociable intrinsic connectivity networks for salience processing and executive control", J Neurosci, 27, pp.2349~2356 (2007)
- Labudda K, "Neural correlates of decision making with explicit information about probabilities and incentives in elderly healthy subjects", Exp Brain Res, 187, pp.641~650 (2008)
- Goldstein RZ, "Severity of neuropsychological impairment in cocaine and alcohol addiction : association with metabolism in the prefrontal cortex", Neuropsychologia, 42, pp.1447~1458 (2004)