FIB 햄스터에서 양파즙과 나린진 추출 혼합물의 항고지혈증 효과 -투과전자현미경적 관찰-
Effects of Onion and Naringin Extract Mixed Products on Antihyperlipidemic Levels of Bio FIB Hamster
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초록
본 연구는 고지혈을 일으킨 햄스터에게 나린진과 양파즙을 투 여하여 고지혈을 낮추는 효과를 조사하고자 하였다. 고지혈 햄스터는 basal diet에 10% 코코넛오일과 0.05% 콜레스테롤로 고지 혈을 일으켰다. 실험군은 5군의 그룹으로 나뉘어 40일간 실험식 이를 각각 제공하였는데 즉 정상군, 대조군, 50%의 양파즙과 50%의 물을 혼합한군(OEN), 100% 양파즙군(OES), 100% 양파 즙과 1% 나린진을 혼합한군(OESN)이다. 나린진을 처리한 그룹 에서는 혈청 총 콜레스테롤, 중성지질 레벨은 현저하게 감소되었 고 HDL 콜레스테롤은 증가하였다. 한편 간조직은 대조군과 비 교하여 미토콘드리아와 핵의 형태가 현저하게 달랐다. 결론적으 로 나린진을 함유한 양파즙은 간에서 콜레스테롤을 감소시켰다. 양파즙과 나린진추출물의 혼합은 콜레스테롤을 감소시키는 시너 지 효과를 나타내었다.
Abstract
This study investigated the effects to lowering hyperlipidemic levels in hamsters by feeding them naringin and onion extracts. The hyperlipidemic levels on all of the hamsters were raised by feeding them with high fat atherogenic diet (HFAD) containing 10% coconut oil and 0.05% cholesterol. The experimental groups were randomly assigned to 5 groups (normal, control, OEN, OES, and OESN) each 6 hamsters over a 40 days period. The control group (HFAD) received a 10% coconut oil and 0.05% cholesterol with basal diet, the OEN group which received an onion extract mixture contaning 50% water and 50% onion extract, the OES group which received 100% onion extract, the OESN group which received 100% onion extract combined with 1% naringin. Serum cholesterol and triglyceride levels significantly decreased in the naringin treated group while the HDL cholesterol level increased. On the other hand, the morphology of the mitochondria and nuclei found in the livers of the treated group given naringin were siginficantly different when compared to those group given high fat diets. In conclusion, onion extract with naringin decreased cholesterol levels in hamster’s livers.
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