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고지방식이를 섭취한 마우스에서 양파껍질 열수 추출물이 혈중지질에 미치는 영향

Effects of Onion Peel Water Extract on the Blood Lipid Profiles in Mice Fed a High-Fat Diet

한상준|김옥진|이현아|홍선화
한국약용작물학회|2014.06|한국약용작물학회지 (KOREAN JOURNAL OF MEDICINAL CROP SCIENCE)|제22권 제3호|pp. 203-209|DOI http://dx.doi.org/10.7783/KJMCS.2014.22.3.203

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키워드

Blood LipidOnionAllium cepa L.Water ExtractOnion PeelBlood Glucose

초록

Onion (Allium cepa L.) is one of the richest sources of flavonoids in human diet. Onion peel contains over 20times more quercetin than onion flesh. In this study, we studied the effects of onion peel water extract (OPE) on the bloodlipid profiles in mice. The onion peel extracts was extracted with hot water. The experimental groups were divided with 3groups (n = 6) of ICR male mice: normal diet + distilled water (NC), high-fat diet + distilled water (HF), high-fatdiet + onion peel water extract 20 ㎎/㎏ (OPE-20). The oral administration was conducted daily. The experimental periodwas 7 weeks. Onion peel water extract showed higher concentration of polyphenol gallic acid and anti-oxidant trolox equivalentthan the ethanol extract. The body weight gain and food efficiency ratio was significantly lower in the OPE-20 group ascompared with HF group (p < 0.05). The epididymal fat and retroperitoneal fat showed significantly lower weights and sizesin the OPE-20 group as compared with HF group (p < 0.05). The serum levels of total cholesterol, LDL cholesterol and triglyceridewere significantly lower in the OPE-20 group as compared with HF group (p < 0.05). The OPE-20 group showedhigher HDL cholesterol concentration than HF group (p < 0.05). Atherogenic index was ignificantly lower in as comparedwith HF group (p < 0.05). The serum levels of glucose, GOT and GPT were significantly lower in the OPE-20 group as comparedwith HF group (p < 0.05). In these results, we suggests that onion peel water extracts supplementation can reduces theserum lipid components and improves the lipid metabolism in hyperlipidemic mice induced with a high-fat diet.

Abstract

Onion (Allium cepa L.) is one of the richest sources of flavonoids in human diet. Onion peel contains over 20times more quercetin than onion flesh. In this study, we studied the effects of onion peel water extract (OPE) on the bloodlipid profiles in mice. The onion peel extracts was extracted with hot water. The experimental groups were divided with 3groups (n = 6) of ICR male mice: normal diet + distilled water (NC), high-fat diet + distilled water (HF), high-fatdiet + onion peel water extract 20 ㎎/㎏ (OPE-20). The oral administration was conducted daily. The experimental periodwas 7 weeks. Onion peel water extract showed higher concentration of polyphenol gallic acid and anti-oxidant trolox equivalentthan the ethanol extract. The body weight gain and food efficiency ratio was significantly lower in the OPE-20 group ascompared with HF group (p < 0.05). The epididymal fat and retroperitoneal fat showed significantly lower weights and sizesin the OPE-20 group as compared with HF group (p < 0.05). The serum levels of total cholesterol, LDL cholesterol and triglyceridewere significantly lower in the OPE-20 group as compared with HF group (p < 0.05). The OPE-20 group showedhigher HDL cholesterol concentration than HF group (p < 0.05). Atherogenic index was ignificantly lower in as comparedwith HF group (p < 0.05). The serum levels of glucose, GOT and GPT were significantly lower in the OPE-20 group as comparedwith HF group (p < 0.05). In these results, we suggests that onion peel water extracts supplementation can reduces theserum lipid components and improves the lipid metabolism in hyperlipidemic mice induced with a high-fat diet.

참고문헌 (36)

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