양파와 한약재를 이용하여 개발된 한약 복합 처방 (HRO-1)이 비만 흰쥐에 미치는 영향
Effects of Herbal Remedy Using Onion (HRO-1) in Body Weight and Serum Level on Obesity in Rats
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The aim of this study was to investigate the effects of herbal remedy using onion (HRO-1) supplementation on body weight change and cholesterol, triglyceride, free fatty acid, total lipid, phospholipid serum level in obesity mice. This study classified 32 of 4 weeks-old male C57BL/6 mice which have obesity caused by high-fat fed into four groups of 8 mice and made the subjects medicated them HRO-1 for 6 weeks. Male C57BL/6 mice were divided into four groups; a normal group, a high-fat group, a high-fat group supplemented with HRO-1(500 ㎎/㎏), a high-fat group supplemented with HRO-1(1000 ㎎/㎏). In respect to the body weight change, there was statistically significant difference between the HRO-1(1000 ㎎/㎏) group compared to high-fat group (p<0.05). In the total cholesterol and LDL cholesterol level, there was statistically significant difference between the HRO-1(1000 ㎎/㎏) group compared to high-fat group (p<0.05). In the triglyceride and free fatty acid level, there was statistically significant difference between the normal group compared to high-fat group (p<0.05). In the total lipid and phospholipid level, there was statistically significant difference between the normal group compared to high-fat group (p<0.05). Also in the total lipid level, there was statistically significant difference between the HRO-1 group compared to high-fat group (p<0.05). The above results suggests that HR0-1 medicated is effective to prevention and treatment of obesity.
Abstract
The aim of this study was to investigate the effects of herbal remedy using onion (HRO-1) supplementation on body weight change and cholesterol, triglyceride, free fatty acid, total lipid, phospholipid serum level in obesity mice. This study classified 32 of 4 weeks-old male C57BL/6 mice which have obesity caused by high-fat fed into four groups of 8 mice and made the subjects medicated them HRO-1 for 6 weeks. Male C57BL/6 mice were divided into four groups; a normal group, a high-fat group, a high-fat group supplemented with HRO-1(500 ㎎/㎏), a high-fat group supplemented with HRO-1(1000 ㎎/㎏). In respect to the body weight change, there was statistically significant difference between the HRO-1(1000 ㎎/㎏) group compared to high-fat group (p<0.05). In the total cholesterol and LDL cholesterol level, there was statistically significant difference between the HRO-1(1000 ㎎/㎏) group compared to high-fat group (p<0.05). In the triglyceride and free fatty acid level, there was statistically significant difference between the normal group compared to high-fat group (p<0.05). In the total lipid and phospholipid level, there was statistically significant difference between the normal group compared to high-fat group (p<0.05). Also in the total lipid level, there was statistically significant difference between the HRO-1 group compared to high-fat group (p<0.05). The above results suggests that HR0-1 medicated is effective to prevention and treatment of obesity.
참고문헌 (17)
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