마그네슘 풍부 해양미네랄 용액이 hairless 마우스의 아토피성 피부염에 미치는 영향
The Effects of Magnesium Rich Sea Mineral Water on Atopic Dermatitis-like Skin Lesions in Hairless Mice
0
조회
0
다운로드
7
인용
0
참고문헌
키워드
초록
Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease that often has asthma and allergic rhinitis. Magnesium salts, the important component of minerals in Dead Sea water, are known to exhibit beneficial effects in inflammatory disease. Favorable effects of magnesium ions and sea water treated to the skin of patients with contact dermatitis have been reported. But histological and immunological investigations are insufficient. This study was performed to examine the inhibitory effect of magnesium-rich sea mineral water on the development of AD-like skin lesions in hairless mice. AD-like skin lesions are induced by the repeated application of 2,4-dinitrochlorobenzene (DNCB). Local application of magnesium-rich sea mineral water on hairless mice skin applied with DNCB inhibited the development of AD-like skin lesions as exemplified by a significant increase in skin hydration (p⁄0.01), and a decrease in epidermal water loss (p⁄0.01). Serum IgE level was also significantly decreased (p⁄0.01). These results suggest that magnesiumrich sea mineral water inhibits the development of DNCB-induced AD-like skin lesions in hairless mice. These observations indicate that magnesium-rich sea mineral water may be alternative and assistant substances for the management of AD.
Abstract
Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease that often has asthma and allergic rhinitis. Magnesium salts, the important component of minerals in Dead Sea water, are known to exhibit beneficial effects in inflammatory disease. Favorable effects of magnesium ions and sea water treated to the skin of patients with contact dermatitis have been reported. But histological and immunological investigations are insufficient. This study was performed to examine the inhibitory effect of magnesium-rich sea mineral water on the development of AD-like skin lesions in hairless mice. AD-like skin lesions are induced by the repeated application of 2,4-dinitrochlorobenzene (DNCB). Local application of magnesium-rich sea mineral water on hairless mice skin applied with DNCB inhibited the development of AD-like skin lesions as exemplified by a significant increase in skin hydration (p⁄0.01), and a decrease in epidermal water loss (p⁄0.01). Serum IgE level was also significantly decreased (p⁄0.01). These results suggest that magnesiumrich sea mineral water inhibits the development of DNCB-induced AD-like skin lesions in hairless mice. These observations indicate that magnesium-rich sea mineral water may be alternative and assistant substances for the management of AD.
참고문헌 (25)
- Barnes PJ, "New direction in allergic: Mechanism-based anti-inflammatory therapies", J Allergy Clin Immunol, 106, pp.5~18 (2000)
- Boguniewicz M, "10. Atopic dermatitis", J Allergy Clin Immunol, 117, pp.475~480 (2006)
- Cooper KD, "T cells in atopic dermatitis", J Am Acad Dermatol, 45, pp.10~12 (2001)
- David M, "Treatment of psoriasis at the Dead Sea: why, how and when", Isr Med Assoc J, 2(3), pp.232~234 (2000)
- Denda M, "Some magnesium salts and a mixture of magnesium and calcium salts accelerate skin barrier recovery", Arch Dermatol Res, 291(10), pp.560~563 (1999)
- Ernst P, "Relative scarcity of asthma and atopy among rural adolescents raised on a farm", Am J Respir Crit Care Med, 161, pp.1563~1566 (2000)
- Even-Paz Z, "The Dead Sea and psoriasis. Historical and geographic background", Int J Dermatol, 28(1), pp.1~9 (1989)
- Foster PS, "Interleukin-4, -5, and -13: emerging therapeutic targets in allergic disease", Pharmacology Therapeutics, 94(3), pp.253~264 (2002)
- Grängsjö A, "X-ray microanalysis of cultured keratinocytes: methodological aspects and effects of the irritant sodium lauryl sulphate on elemental composition", J Microsc, 199, pp.208~213 (2000)
- Inagaki N, "Drugs for the treatment of allergic diseases", Pharmacol, 86(3), pp.275~280 (2001)
- Lee SH, "Calcium and potassium are important regulators of barrier homeostasis in murine epidermis", J Clin Invest, 89(2), pp.530~538 (1992)
- Leicht S, "Atopic dermatitis. How to incorporate advances in management", Postgrad Med, 109, pp.119~127 (2001)
- Leung DY, "Atopic dermatitis", Lancet, 361, pp.151~160 (2003)
- Leung DY, "Role of IgE in atopic dermatitis", Curr Opin Immunol, 5, pp.956~962 (1993)
- Lodén M, "Friction, capacitance and transepidermal water loss (TEWL) in dry atopic and normal skin", Br J Dermatol, 126, pp.137~141 (1992)
- Matsumoto K, "Establishment of an atopic dermatitis-like skin model in a hairless mouse by repeated elicitation of contact hypersensitivity that enables to conduct functional analyses of the stratum corneum with various non-invasive biophysical instruments", Skin Res Technol, 10(2), pp.122~129 (2004)
- Proksch E, "Bathing in a magnesium-rich Dead sea salt solution improves skin barrier function, enhances skin hydration, and reduces inflammation in atopic dry skin", Int J Dermatol, 44(2), pp.151~157 (2005)
- Schempp CM, "Magnesium ions inhibit the antigen-presenting function of human epidermal Langerhans cells in vivo and in vitro. Involvement of ATPase, HLA-DR, B7 molecules, and cytokines", J Invest Dermatol, 115(4), pp.680~686 (2000)
- Shultz LF, "Epidemiology of atopic dermatitis", Immunol Allergy Clin North Am, 22, pp.1~27 (2002)
- Stein RT, "Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years", Lancet, 354, pp.541~545 (1999)
- Uehara M, "Blood eosinophilia in atopic dermatitis", Clin Exp Dermatol, 15, pp.264~266 (1990)
- abe M, "Functional analyses of the superficial stratum corneum in atopic xerosis", Arch Dermatol, 127, pp.1689~1692 (1991)
- Yoon SP, "The environment and lifestyle of atopic dermatitis patients", Korean J Dermatol, 37, pp.983~991 (1999)
- Yoshizawa Y, "Topical dinitrochlorobenzene therapy in the treatment of refractory atopic dermatitis: systemic immunotherapy", J Am Acad Dermatol, 42, pp.258~262 (2000)
- Yoshizawa Y, "Water, salts and skin barrier of normal skin", Skin Res Technol, 9(1), pp.31~33 (2003)