2,4-Dinitrochlorobenzene으로 유도된 BALB/c 마우스에서 Black currant seed oil의 아토피성 피부염 억제 효과
Inhibitory Effects of Black currant seed oil on 2,4-Dinitrochlorobenzene Induced Atopic Dermatitis in BALB/c Mice Model
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This study investigated the clinical parameters of atopic dermatitis and evaluated the inhibitory effects of Black currant seed oil for atopic dermatitis by using a Dinitrochlorobenzene(DNCB) induced BALB/c mice model. Five-week-old BALB/c mice were divided into four groups: normal group (N, non-treated), control group (C, atopic dermatitis-induced), positive control group (PC, Tacrolimus ointment-treated against induced atopic dermatitis, PC), experiment group (E, Black currant seed oil-treated against induced atopic dermatitis). After induction of atopic dermatitis by DNCB, the erythema, edema, eschar, and scratching were severely observed. The symptoms of atopic dermatitis were improved after 2 weeks, and almost disappeared after 4 weeks in PC and E group. The increased frequencies of scratching in C group were decreased in PC and E group. Transepidermal water loss, erythema index and serum IgE level were significantly decreased in E and PC compared to that in C after 4 weeks of the treatment. The results indicated that Black currant seed oil can relieve atopic dermatitis symptoms effectively, and may be possibly used as a functional material for suppression of atopic dermatitis.
Abstract
This study investigated the clinical parameters of atopic dermatitis and evaluated the inhibitory effects of Black currant seed oil for atopic dermatitis by using a Dinitrochlorobenzene(DNCB) induced BALB/c mice model. Five-week-old BALB/c mice were divided into four groups: normal group (N, non-treated), control group (C, atopic dermatitis-induced), positive control group (PC, Tacrolimus ointment-treated against induced atopic dermatitis, PC), experiment group (E, Black currant seed oil-treated against induced atopic dermatitis). After induction of atopic dermatitis by DNCB, the erythema, edema, eschar, and scratching were severely observed. The symptoms of atopic dermatitis were improved after 2 weeks, and almost disappeared after 4 weeks in PC and E group. The increased frequencies of scratching in C group were decreased in PC and E group. Transepidermal water loss, erythema index and serum IgE level were significantly decreased in E and PC compared to that in C after 4 weeks of the treatment. The results indicated that Black currant seed oil can relieve atopic dermatitis symptoms effectively, and may be possibly used as a functional material for suppression of atopic dermatitis.
참고문헌 (25)
- Boguniewicz, M., "Atopic dermatitis", J Allergy Clin Immunol, 117, pp.475~480 (2006)
- Leung, D. Y. M., "Atopic dermatitis", Lancet, 361, pp.151~160 (2003)
- Su, R. C., "Epigenetic regulation of established human type 1 versus type 2 cytokine responses", J Allergy Clin Immunol, 121, pp.57~63 (2008)
- Novak, N., "Allergic and nonallergic forms of atopic diseases", J Allergy Clin Immunol, 112, pp.252~262 (2003)
- 김민아, "신선초 추출물의 아토피 억제활성", 한국식품저장유통학회지, 19(5), pp.792~798 (2012), 한국식품저장유통학회
- Jartti, T., "Association between CD4+CD25high T cells and atopy in children", J Allergy Clin Immunol, 120, pp.177~183 (2007)
- Leung, D. Y. M., "Cellular and immunologic mechanisms in atopic dermatitis", J Am Acad Dermatol, 44, pp.1~12 (2001)
- Wills-Karp, M, "Interleukin-13 in asthma pathogenesis", Curr Allergy Asthma Rep, 4, pp.123~131 (2004)
- Ainley-Walker, P. F., "Side to side comparison of topical treatment in atopic dermatitis", Arch Dis Child, 79, pp.149~152 (1998)
- Hanifin, J. M., "Guidelines of care for atopic dermatitis", J Am Acad Dermatol, 50, pp.391~404 (2004)
- Hoare, C., "Systematic review of treatments for atopic eczema", Health Technol Assess, 4, pp.1~191 (2000)
- Artemis, P. S, "Omega-3 fatty acids and cardiovascular disease : the epidemiological evidence", Environ Health Prev Med, 6, pp.203~209 (2002)
- Chung. S., "Gamma-linolenic acid in borage oil reverses epidermal hyperproliferation in guinea pigs", J Nutr, 132, pp.3090~3097 (2002)
- Olsen, S. F., "Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring : y of registry-based follow-up from a randomized controlled trial", Am J Clin Nutr, 88, pp.167~175 (2008)
- 노경희, "RAW264.7 Macrophage Cell에서 녹차씨껍질 에틸아세테이트 분획의 염증억제 효과 및 기전 연구", 한국식품영양과학회지, 40(5), pp.625~634 (2011), 한국식품영양과학회
- Chang, C. S., "Gamma-linolenic acid inhibits inflammatory responses by regulating Nf-κB and AP-1 activation in lipopolysaccharide -induced RAW 264.7 macrophages", Inflammation, 33, pp.46~57 (2010)
- Linnamaa, P., "Blackcurrant seed oil for prevention of atopic dermatitis in newborns : a randomized, double-blind, placebo-controlled trial", Clin Exp Allergy, 40, pp.1247~1255 (2010)
- Akdis, CA., "Diagnosis and treatment of atopic dermatitis in children and adults : european academy of allergology and clinical immunology", American academy of allergy, asthma and immunology, J Allergy Clin Immunol, pp.2006, 118[DOI]
- Weidinger, S., "Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis", J Invest Dermatol, 127, pp.724~726 (2007)
- 김동희, "마그네슘 풍부 해양미네랄 용액이 hairless 마우스의 아토피성 피부염에 미치는 영향", 한국현미경학회지, 38(3), pp.167~174 (2008), 한국현미경학회
- Dooper, M. M. B. W., "Dihomo-γ-linolenic acid inhibits tumour necrosis factor-α production by human leucocytes independently of cyclooxygenase activity", Immunology, 110, pp.348~357 (2003)
- production by human monocytes, "J Clin Immunol", 2002, 83~91
- Yen, C. H., "Chiang, B.L. Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis", Ann Allergy Asthma Immunol, 100, pp.66~73 (2008)
- 정종문, "제Ⅰ형 알레르기 반응이 유도된 생쥐에서 식물추출 복합물(PEM381)의 효과", 한국식품영양과학회지, 36(11) (2007), 한국식품영양과학회
- Calder, P. C., "Fatty acids and lymphocyte functions", Br J Nutr, 87, pp.31~48 (2002)