본문 바로가기
KERD
논문KCI 등재

인간 착상 과정에 자궁내막과 배아의 역할

The Role of the Endometrium and Embryo in Human Implantation

지병철
한국발생생물학회 (The Korea Society Of Developmental Biology)|2009.03|발생과 생식 (DEVELOPMENT & REPRODUCTION)|제13권 제1호|pp. 1-11

2

조회

0

다운로드

0

인용

0

참고문헌

주제분류생물학

초록

착상은 배아측과 모체측의 내분비적, 측분비적 및 자가분비적 인자들의 상호 작용에 의하여 조절된다. 착상의 적기는 2～4일로서 이 특수한 시간대 안에서 signaling, appositioning, attachment 및 invasion을 통하여 순차적으로 배아의 착상이 이루어지는데 이는 자궁내막과 배아로부터 여러 사이토카인, 성장인자, 부착인자와 같은 다수의 생화학 인자의 생성과 분비를 포함하며 이로 인하여 수용적인 자궁내막이 형성된다. LIF, CSF-1, IL-1과 같은 사이토카인들은 착상을 이끄는 연속적인 사건에서 중요한 역할을 수행하며 integrin, L-selectin ligands, glycodelin, mucin-1, HB-EGF, pinopodes는 appositioning과 attachment에 관여한다. 배아 또한 사이토카인과 성장인자 및 LIF, CSF-1, IGF, HB-EGF에 대한 수용체들을 분비하여 능동적으로 대처한다. 자궁내막의 수용성을 평가하고 자연주기 또는 보조생식술을 이용한 임신의 예후를 예측하는 데 이와 같은 인자들이 유용한지는 앞으로 더 연구되어야 한다. 현재로서는 내막조직으로부터 채취한 integrins, pinopodes, glycodelin, LIF가, 자궁강내 세척액에서는 glycodelin과 LIF가 유망한 인자로 떠오르고 있다. 혈액내 마커로서는 VEGF, glycodelin, CSF가 약간의 연관성을 보여주고 있다. 이러한 인자들이 보조생식술 전후로 자궁내막의 기능과 임신의 예후를 평가하는 선별검사로 이용될 수 있는지를 증명하기 위해서는 향후 불임 여성과 대조군인 가임 여성을 대상으로 한 대규모의 연구가 필요할 것이다. 인간의 착상에서 이들 인자들의 기능을 충분히 이해해야 치료적 기법으로 연결되어 보조생식술에서도 더 높은 성공률을 이루어 낼 것으로 사료된다.

Abstract

Implantation itself is governed by an array of endocrine, paracrine and autocrine modulators, of embryonic and maternal origin. Window of implantation is the unique temporal and spatial expression of factors allows the embryo to implant via signaling, appositioning, attachment, and invasion in a specific time frame of 2-4 days. When the embryo has arrived in the uterine cavity, a preprogrammed sequence of events occurs, which involves the production and secretion of a multitude of biochemical factors such as cytokines, growth factors, and adhesion molecules by the endometrium and the embryo, thus leading to the formation of a receptive endometrium. Cytokines such as LIF, CSF-1, and IL-1 have all been shown to play important roles in the cascade of events that leads to implantation. Integrin, L-selectin ligands, glycodelin, mucin-1, HB-EGF and pinopodes are involved in appositioning and attachment. The embryo also produces cytokines and growth factors (ILs, VEGF) and receptors for endometrial signals such as LIF, CSF-1, IGF and HB-EGF. The immune system and angiogenesis play an important role. The usefulness of these factors to assess endometrial receptivity and to estimate the prognosis for pregnancy in natural and artificial cycles remains to be proven. Integrins, pinopodes, glycodelin and LIF (from biopsies) are promising candidates; from uterine flushings, glycodelin and LIF are also candidates. The ideal serum marker is not available, but VEGF, glycodelin and CSF have some clinical implications. Further evaluation that includes larger groups of infertile women and fertile controls are needed to elucidate whether their presence in plasma, flushing fluid, or endometrial samples can be used as some kind of a screening tool to assess endometrial function and prognosis for pregnancy before and after artificial reproductive therapy. A better understanding of their function in human implantation may lead to therapeutic intervention, thereby improving the success rate in reproduction treatment. New molecular techniques are becoming available for measuring both embryonic and endometrial changes prior to and during implantation. The use of predictive sets of markers may prove to be more reliable than a single marker. Ultimately, the aim is to use these tools to increase implantation in artificial cycles and consequently improve live-birth rates.

참고문헌 (40)

  1. Achache H, "Endometrial receptivity markers, the journey to successful embryo implantation", Hum Reprod Update, 12, pp.731~746 (2006)
  2. Borthwick JM, "Determination of the transcript profile of human endometrium", Mol Hum Reprod, 9, pp.19~33 (2003)
  3. Bourgain C, "The endometrium in stimulated cycles for IVF", Hum Reprod Update, 9, pp.515~522 (2003)
  4. Carson DD, "Changes in gene expression during the early to mid‐luteal (receptive phase) transition in human endometrium detected by high-density microarray screening", Mol Hum Reprod, 8, pp.871~879 (2002)
  5. Devroey P, "Reproductive biology and IVF: ovarian stimulation and endometrial receptivity", Trends Endocrinol Metab, 15, pp.84~90 (2004)
  6. Diedrich K, "The role of the endometrium and embryo in human implantation", Hum Reprod Update, 13, pp.365~377 (2007)
  7. Dimitriadis E, "Cytokines, chemokines and growth factors in endometrium related to implantation", Hum Reprod Update, 11, pp.613~630 (2005)
  8. Dimitriadis E, "Interleukin-11 receptor alpha and leukemia inhibitory factor are dysregulated in endometrium of infertile women with endometriosis during the implantation window", J Reprod Immunol, 69, pp.53~64 (2006)
  9. Dobson AT, "The unique transcriptome through day 3 of human preimplantation development", Hum Mol Genet, 13, pp.1461~1470 (2004)
  10. Dominguez F, "Human endometrial receptivity: a genomic approach", Reprod Biomed Online, 6, pp.332~338 (2003)
  11. Dorn C, "Leptin, VEGF, IGF-1, and IGFBP-3 concentrations in serum and follicular fluid of women undergoing in vitro fertilization", Arch Gynecol Obstet, 268, pp.187~193 (2003)
  12. Emiliani S, "Embryo-maternal interactive factors regulating the implantation process: implications in assisted reproductive", Reprod Biomed Online, 10, pp.527~540 (2005)
  13. Fazleabas AT, "Physiology and pathology of implantation in the human and nonhuman primate", Semin Reprod Med, 25, pp.405~409 (2007)
  14. Guzeloglu-Kayisli O, "Basic aspects of implantation", Reprod Biomed Online, 15, pp.728~-739 (2007)
  15. Hannan NJ, "Role of chemokines in the endometrium and in embryo implantation", Curr Opin Obstet Gynecol, 19, pp.266~272 (2007)
  16. Hoozemans DA, "Human embryo implantation: current knowledge and clinical implications in assisted reproductive technology", Reprod Biomed Online, 9, pp.692~715 (2004)
  17. Horcajadas JA, "Determinants of endometrial receptivity", Ann N Y Acad Sci, 1034, pp.166~175 (2004)
  18. Jinno M, "Measurement of endometrial tissue blood flow: a novel way to assess uterine receptivity for implantation", Fertil Steril, 76, pp.1168~1174 (2001)
  19. Jones GM, "Novel strategy with potential to identify developmentally competent IVF blastocysts", Hum Reprod, 23, pp.1748~1759 (2008)
  20. Kao LC, "Global gene profiling in human endometrium during the window of implantation", Endocrinology, 143, pp.2119~138 (2002)
  21. Katz-Jaffe MG, "Proteomic analysis of individual human embryos to identify novel biomarkers of development and viability", Fertil Steril, 85, pp.101~107 (2006)
  22. Kennedy TG, "Prostaglandins and the initiation of blastocyst implantation and decidualization", Reproduction, 134, pp.635~643 (2007)
  23. Kodaman PH, "Hormonal regulation of implantation", Obstet Gynecol Clin North Am, 31, pp.745~766 (2004)
  24. Lessey BA, "Integrin adhesion molecules in the human endometrium. Correlation with the normal and abnormal menstrual cycle", J Clin Invest, 90, pp.188~195 (1992)
  25. Lindhard A, "Biochemical evaluation of endometrial function at the time of implantation", Fertil Steril, 78, pp.221~233 (2002)
  26. Margalioth EJ, "Investigation and treatment of repeated implantation failure following IVF-ET", Hum Reprod, 21, pp.3036~3043 (2006)
  27. Minas V, "Factors controlling blastocyst implantation", Reprod Biomed Online, 10, pp.205~216 (2005)
  28. Munne S, "Preimplantation genetic diagnosis and human implantation-a review", Placenta, 24(B), pp.S70~S76 (2003)
  29. Noyes RW, "Dating the endometrial biopsy", Fertil Steril, 1, pp.3~25 (1950)
  30. Riesewijk A, "Gene expression profiling of human endometrial receptivity on days LH+2 versus LH+7 by microarray technology", Mol Hum Reprod, 9, pp.253~264 (2003)
  31. Robb L, "Leukemia inhibitory factor and interleukin-11: cytokines with key roles in implantation", J Reprod Immunol, 57, pp.129~141 (2002)
  32. Sakkas D, "Noninvasive methods to assess embryo quality", Curr Opin Obstet Gynecol, 17, pp.283~288 (2005)
  33. Salamonsen LA, "Cytokines and chemokines during human embryo implantation: roles in implantation and early placentation", Semin Reprod Med, 25, pp.437~444 (2007)
  34. Scarpellini F, "Effectiveness of GM-CSF1 in the treatment of habitual abortion in a controlled study", Fertil Steril, 80(3), pp.S288~ (2003)
  35. Seif M, "Assisted hatching on assisted conception (IVF & ICSI)", Cochrane Database Syst Rev
  36. Spandorfer SD, "Autologous endometrial coculture in patients with in vitro-fertilization (IVF) failure: correlations of outcome with leukemia inhibiting factor (LIF) production", Am J Reprod Immunol, 46, pp.375~380 (2001)
  37. Srisuparp S, "Signaltransduction pathways activated by chorionic gonadotropin in the primate endometrial epithelial cells", Biol Reprod, 68, pp.457~464 (2003)
  38. Stafford-Bell MA, "Surrogacy in Australia: implantation rates have implications for embryo quality and uterine receptivity", Reprod Fertil Dev, 13, pp.99~104 (2001)
  39. Sunder S, "Endocrinology of the peri- implantation period", Bailliere’s Best Pract Res Cli Obstet Gynaecol, 14, pp.789~800 (2000)
  40. Yanaihara A, "Comparison in gene expression of secretory human endometrium using laser microdissection", Reprod Biol Endocrinol, 2, pp.66~ (2004)

관련 논문AI추천

A Review of Mechanisms of Implantation김수미, 김종수한국발생생물학회 · 발생과 생식2017 · 제21권 제4호자궁내막 Heparin-Binding EGF-like Growth Factor (HB-EGF)의 발현에 미치는 외인성 성선자극호르몬의 작용구승엽, 김석현, 김정구, 문신용, 서창석, 이진용, 지병철, 최영민대한산부인과학회 · Obstetrics & Gynecology Science2005 · 제48권 제5호생쥐 배아에서 과립구 대식세포 증식인자가 착상관련 유전자 발현에 미치는 영향김재령, 김혜민, 김효정, 문혜성, 박원일, 박은주, 신정환, 이진용, 차병헌, 홍서유대한산부인과학회 · Obstetrics & Gynecology Science2008 · 제51권 제2호Transcriptomic patterns in early-secretory and mid-secretory endometrium in a natural menstrual cycle immediately before in vitro fertilization and embryo transfer이재훈, 조시현, 최영식, Dowon Lee, Hyemin Park, Inha Lee, Joo Hyun Park, Sung Pil Choo대한산부인과학회 · Obstetrics & Gynecology Science2023 · 제66권 제5호Effects of EGF and PAF on the Hatching and Implantation of Peri-implantation Stage Embryos전용필한국발생생물학회 · 발생과 생식2010 · 제14권 제1호체외수정시술시 예후 예측에 관한 혈중 인슐린유사 성장인자 및 결합단백질의 임상적 효용성구승엽, 김석현, 김정구, 문신용, 서창석, 지병철, 최영민대한산부인과학회 · Obstetrics & Gynecology Science2003 · 제46권 제4호

이 간행물의 다른 논문 (5건)

미토콘드리아의 구조적 역동성의 신경계 발생 과정 기능 고찰조봉기, 선웅pp. 13-23흰넓적다리 붉은쥐(Apodemus speciosus peninsulae)의 세정관 상피주기이정훈, 김미진pp. 25-33겨울철 사육조건이 양식산 뱀장어 Anguilla japonica의 인위적인 성성숙 유도 및 번식에 미치는 영향김대중, 박미선, 이정의, 허윤성, 최용기, 김이청, 손맹현pp. 35-41Effects of the Vibration Stress on Cortisol and Hematological Characteristics in Soft-shelled Turtle, Pelodiscus sinensis장영진, 박인석, 이정열, 배승철, 허준욱pp. 43-49흰쥐황체에서 MCP-1과 큰포식세포아형의 역할에 관한 면역조직화학적 연구김원식, 조근자, 김수일pp. 51-57
원문 보기