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A Review of Mechanisms of Implantation

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초록

Implantation is a highly organized process that involves an interaction between a receptive uterus and a com-petent blastocyst. In humans, natural fecundity suggests that the chance of conception per cycle is relatively low (~30%) and two-third of lost pregnancies occur because of implantation failure. Defective implantation leads to adverse pregnancy out-comes including infertility, spontaneous miscarriage, intrauterine fetal growth restriction and preeclampsia. With use of advanced scientific technologies, gene expression analysis and genetically-engineered animal models have revealed critical cellular networks and molecular pathways. But, because of ethical restrictions and the lack of a mechanistic experiment, comprehen-sive steps in human implantation have still not been completely understood. This review primarily focuses on the recent ad-vances in mechanisms of implantation. Because infertility is an emerging issue these days, gaining an understanding the mo-lecular and hormonal signaling pathway will improve the outcome of natural pregnancy and assisted reproductive technology.

Abstract

Implantation is a highly organized process that involves an interaction between a receptive uterus and a com-petent blastocyst. In humans, natural fecundity suggests that the chance of conception per cycle is relatively low (~30%) and two-third of lost pregnancies occur because of implantation failure. Defective implantation leads to adverse pregnancy out-comes including infertility, spontaneous miscarriage, intrauterine fetal growth restriction and preeclampsia. With use of advanced scientific technologies, gene expression analysis and genetically-engineered animal models have revealed critical cellular networks and molecular pathways. But, because of ethical restrictions and the lack of a mechanistic experiment, comprehen-sive steps in human implantation have still not been completely understood. This review primarily focuses on the recent ad-vances in mechanisms of implantation. Because infertility is an emerging issue these days, gaining an understanding the mo-lecular and hormonal signaling pathway will improve the outcome of natural pregnancy and assisted reproductive technology.

참고문헌 (68)

  1. Bischof P, "Trophoblast differentiation and invasion: its significance for human embryo implantation", Early Pregnancy, 3, pp.81~95 (1997)
  2. Burrows TD, "Trophoblast migration during human placental implantation", Hum Reprod Update, 2, pp.307~321 (1996)
  3. Cha J, "Mechanisms of implantation:strategies for successful pregnancy", Nat Med, 18, pp.1754~1767 (2012)
  4. Chillaron J, "Heteromeric amino acid transporters: biochemistry, genetics, and physiology", Am J Physiol Renal Physiol, 281, pp.995~1018 (2001)
  5. Cohen M, "Metalloproteinases and human placental invasiveness", Placenta, 27, pp.783~793 (2006)
  6. Das SK, "Heparinbinding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation", Development, 120, pp.1071~1083 (1994)
  7. Dominguez F, "Embryologic outcome and secretome profile of implanted blastocysts obtained after coculture in human endometrial epithelial cells versus the sequential system", Fertil Steril, 93, pp.774~782 (2010)
  8. Dominguez F, "New strategy for diagnosing embryo implantation potential by combining proteomics and time-lapse technologies", Fertil Steril, 104, pp.908~914 (2015)
  9. Dominguez F, "Human endometrial CD98 is essential for blastocyst adhesion", PLoS One, 5, pp.e13380~ (2010)
  10. Emonard H, "Type IV and interstitial collagenolytic activities in normal and malignant trophoblast cells are specifically regulated by the extracellular matrix", Invasion Metastasis, 10, pp.170~177 (1990)
  11. Fukuda MN, "Signal transduction in human embryo implantation", Cell Cycle, 6, pp.1153~1156 (2007)
  12. Genbacev OD, "Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface", Science, 299, pp.405~408 (2003)
  13. Ghosh D, "Luteal phase ovarian oestrogen is not essential for implantation and maintenance of pregnancy from surrogate embryo transfer in the rhesus monkey", Hum Reprod, 9, pp.629~637 (1994)
  14. Gipson IK, "MUC16 is lost from the uterodome (pinopode) surface of the receptive human endometrium: in vitro evidence that MUC16 is a barrier to trophoblast adherence", Biol Reprod, 78, pp.134~142 (2008)
  15. Graham CH, "Localization of transforming growth factor-β at the human fetal-maternal interface: role in trophoblast growth and differentiation", Biol Reprod, 46, pp.561~572 (1992)
  16. Greening DW, "Modulating the endometrial epithelial proteome and secretome in preparation for pregnancy:The role of ovarian steroid and pregnancy hormones", J Proteomics, 144, pp.99~112 (2016)
  17. Hambartsoumian E, "Endometrial leukemia inhibitory factor (LIF) as a possible cause of unexplained infertility and multiple failures of implantation", Am J Reprod Immunol, 39, pp.137~143 (1998)
  18. Hantak AM, "Role of uterine stromal-epithelial crosstalk in embryo implantation", Int J Dev Biol, 58, pp.139~146 (2014)
  19. Hunkapiller NM, "A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia", Development, 138, pp.2987~2998 (2011)
  20. Iacob D, "Decorin-mediated inhibition of proliferation and migration of the human trophoblast via different tyrosine kinase receptors", Endocrinology, 149, pp.6187~6197 (2008)
  21. Kadokawa Y, "Expression pattern of E‐and P‐Cadherin in mouse embryos and uteri during the periimplantation period", Dev Growth Differ, 31, pp.23~30 (1989)
  22. Karmakar S, "Regulation of trophoblast invasion by IL‐1β and TGF‐β1", Am J Reprod Immunol, 48, pp.210~219 (2002)
  23. 김미옥, "Effect of a Mind-Body Therapeutic Program for Infertile Women Repeating In Vitro Fertilization Treatment on Uncertainty, Anxiety, and Implantation Rate", Asian Nursing Research, 8(1), pp.49~56 (2014), 한국간호과학회
  24. Klentzeris LD, "Infertility: Beta-1 integrin cell adhesion molecules in the endometrium of fertile and infertile women", Hum Reprod, 8, pp.1223~1230 (1993)
  25. Krüssel JS, "Regulation of embryonic implantation", Eur J Obstet Gynecol Reprod Biol, 110, pp.S2~S9 (2003)
  26. Krege JH, "Generation and reproductive phenotypes of mice lacking estrogen receptor β", Proc Natl Acad Sci U S A, 95, pp.15677~15682 (1998)
  27. Laird SM, "The production of leukaemia inhibitory factor by human endometrium: presence in uterine flushings and production by cells in culture", Hum Reprod, 12, pp.569~574 (1997)
  28. Hye-Rim Lee, "Functions and physiological roles of two types of estrogen receptors, ERα and ERβ, identified by estrogen receptor knockout mouse", Laboratory Animal Research, 28(2), pp.71~76 (2012), 한국실험동물학회
  29. Lessey BA, "Integrin adhesion molecules in the human endometrium. Correlation with the normal and abnormal menstrual cycle", J Clin Invest, 90, pp.188~195 (1992)
  30. Lim H, "Multiple female reproductive failures in cyclooxygenase 2-deficient mice", Cell, 91, pp.197~208 (1997)
  31. Lubahn DB, "Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene", Proc Natl Acad Sci USA, 90, pp.11162~11166 (1993)
  32. Lyall F, "Mechanisms regulating cytotrophoblast invasion in normal pregnancy and pre‐eclampsia", Aust N Z J Obstet Gynaecol, 46, pp.266~273 (2006)
  33. Lydon JP, "Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities", Genes Dev, 9, pp.2266~2278 (1995)
  34. Ma WG, "Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation", Proc Natl Acad Sci USA, 100, pp.2963~2968 (2003)
  35. Martel D, "Scanning electron microscopy of postovulatory human endometrium in spontaneous cycles and cycles stimulated by hormone treatment", J Endocrinol, 114, pp.319~324 (1987)
  36. McEwan M, "Cytokine regulation during the formation of the fetal–maternal interface: Focus on cell–cell adhesion and remodelling of the extracellular matrix", Cytokine Growth Factor Rev, 20, pp.241~249 (2009)
  37. Mote PA, "Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle", Endocrinology, 147, pp.5503~5512 (2006)
  38. Mulac-Jericevic B, "Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform", Science, 289, pp.1751~1754 (2000)
  39. Naeslund G, "Transmission electron microscopy of mouse blastocysts activated and growth-arrested in vivo and in vitro", Anat Embryol, 159, pp.33~48 (1980)
  40. Navot D, "The window of embryo transfer and the efficiency of human conception in vitro", Fertil Steril, 55, pp.114~118 (1991)
  41. Nejatbakhsh R, "Subcellular localization of L-selectin ligand in the endometrium implies a novel function for pinopodes in endometrial receptivity", Reprod Biol Endocrinol, 10, pp.46~ (2012)
  42. Nicola C, "Roles of Rho guanosine 5’-triphosphatase A, Rho kinases, and extracellular signal regulated kinase (1", 2) in prostaglandin E2-mediated migration of first-trimester human extravillous trophoblast, 2007, pp.149, 1243~1251
  43. Norwitz ER, "Implantation and the survival of early pregnancy", N Engl J Med, 345, pp.1400~1408 (2001)
  44. Paria BC, "Blastocyst's state of activity determines the "window" of implantation in the receptive mouse uterus", Proc Natl Acad Sci USA, 90, pp.10159~10162 (1993)
  45. Paria BC, "Heparin-binding EGF-like growth factor interacts with mouse blastocysts independently of ErbB1: a possible role for heparan sulfate proteoglycans and ErbB4 in blastocyst implantation", Development, 126, pp.1997~2005 (1999)
  46. Pollard JW, "A pregnancy defect in the osteopetrotic (opop)mouse demonstrates the requirement for CSF-1 in female fertility", Dev Biol, 148, pp.273~283 (1991)
  47. Psychoyos A, "Uterine receptivity for nidation", Ann N Y Acad Sci, 476, pp.36~42 (1986)
  48. Quinn CE, "Pinopodes: a questionable role in endometrial receptivity", Hum Reprod Update, 15, pp.229~236 (2008)
  49. Raab G, "Mouse preimplantation blastocysts adhere to cells expressing the transmembrane form of heparin-binding EGF-like growth factor", Development, 122, pp.637~645 (1996)
  50. Ramathal CY, "Endometrial decidualization: Of mice and men", Semin Reprod Med, 28, pp.17~26 (2010)
  51. Rao AJ, "Establishment of the need for oestrogen during implantation in non-human primates", Reprod Biomed Online, 14, pp.563~571 (2007)
  52. Rowlands TM, "Cadherins: Crucial regulators of structure and function in reproductive tissues", Rev Reprod, 5, pp.53~61 (2000)
  53. Schatz F, "Plasminogen activator activity during decidualization of human endometrial stromal cells is regulated by plasminogen activator inhibitor 1", J Clin Endocrinol Metab, 80, pp.2504~2510 (1995)
  54. Shimonovitz S, "Developmental regulation of the expression of 72 and 92 kd type IV collagenases in human trophoblasts: A possible mechanism for control of trophoblast invasion", Am J Obstet Gynecol, 171, pp.832~838 (1994)
  55. Simón C, "Cytokines-adhesion molecules-invasive proteinases. The missing paracrine", autocrine link in embryonic implantation?, 1996, pp.2, 405~424
  56. Simón C, "Increasing uterine receptivity by decreasing estradiol levels during the preimplantation period in high responders with the use of a follicle-stimulating hormone step-down regimen", Fertil Steril, 70, pp.234~239 (1998)
  57. Stavreus-Evers A, "Co-existence of heparin-binding epidermal growth factor-like growth factor and pinopodes in human endometrium at the time of implantation", Mol Hum Reprod, 8, pp.765~769 (2002)
  58. Stewart CL, "Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor", Nature, 359, pp.76~79 (1992)
  59. Strickland S, "Plasminogen activator in early embryogenesis: enzyme production by trophoblast and parietal endoderm", Cell, 9, pp.231~240 (1976)
  60. Surveyor GA, "Expression and steroid hormonal control of Muc-1 in the mouse uterus", Endocrinology, 136, pp.3639~3647 (1995)
  61. Sutherland AE, "Developmental regulation of integrin expression at the time of implantation in the mouse embryo", Development, 119, pp.1175~1186 (1993)
  62. Takeichi M, "The cadherins: cell-cell adhesion molecules controlling animal morphogenesis", Development, 102, pp.639~655 (1988)
  63. Thie M, "Cell adhesion to the apical pole of epithelium: a function of cell polarity", Eur J Cell Biol, 66, pp.180~191 (1995)
  64. Thomas K, "Plasma LH-HCG, 17-estradiol, estrone and progesterone monitoring around ovulation and subsequent nidation", Int J Fertil, 18, pp.65~73 (1973)
  65. Tsurudome M, "Function of fusion regulatory proteins (FRPs) in immune cells and virus-infected cells", Crit Rev Immunol, 20, pp.167~196 (2000)
  66. Van der Weiden RM, "Influence of prostaglandins and platelet activating factor on implantation", Hum Reprod, 6, pp.436~442 (1991)
  67. Wang B, "High expression of l‐selectin ligand in secretory endometrium is associated with better endometrial receptivity and facilitates embryo implantation in human being", Am J Reprod Immunol, 60, pp.127~134 (2008)
  68. Wilcox AJ, "Time of implantation of the conceptus and loss of pregnancy", N Engl J Med, 1999, pp.1796~1799 (1999)

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