지구성 운동과 셀레늄 투여가 노화 GK 흰쥐의 미토콘드리아 전사인자 발현에 미치는 영향
The Effects of Endurance Exercise and Selenium Treatment on Mitochondrial Transcription Factors Expression in Old GK Rats
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The objective of this study is to identify the effects of endurance exercise and selenium on mitochondrial transcription factor in old Goto-Kakizaki (GK) rats. In this experiments, endurance exercise were treadmill-run at 24 m/min, 30 min/day, 5 days/week, 6 weeks and 5 umol/㎏ of sodium selenite was injected intraperitoneally. In exercise group, selenium group, and combination group, the mitohondrial biogenesis-related genes, including PGC-1α, NRF-1, and Tfam expression level were significantly increased compared to control group. Consistent with the increased biogenesis-related genes, the cytochrome C in the treated groups, which was the indicator of mitochondrial content, was significantly increased compared to control group. Especially, combination of exercise and selenium may be effective in the increase of mitochondrial biogenesis, activity and insulin sensitivity. Therefore, exercise and selenium treatment is likely to promote diabetic- mitochondrial malfunction and then improve diabetes.
Abstract
The objective of this study is to identify the effects of endurance exercise and selenium on mitochondrial transcription factor in old Goto-Kakizaki (GK) rats. In this experiments, endurance exercise were treadmill-run at 24 m/min, 30 min/day, 5 days/week, 6 weeks and 5 umol/㎏ of sodium selenite was injected intraperitoneally. In exercise group, selenium group, and combination group, the mitohondrial biogenesis-related genes, including PGC-1α, NRF-1, and Tfam expression level were significantly increased compared to control group. Consistent with the increased biogenesis-related genes, the cytochrome C in the treated groups, which was the indicator of mitochondrial content, was significantly increased compared to control group. Especially, combination of exercise and selenium may be effective in the increase of mitochondrial biogenesis, activity and insulin sensitivity. Therefore, exercise and selenium treatment is likely to promote diabetic- mitochondrial malfunction and then improve diabetes.
참고문헌 (21)
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