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Nesfatin-1 as a New Potent Regulator in Reproductive System

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초록

Nesfatin-1 is a recently discovered anorexigenic peptide which is distributed in several brain areas implicated in the feeding and metabolic regulation. Recently, it has been reported that nesfatin-1 is expressed not only in brain, but also in peripheral organs such as digestive organs, adipose tissues, heart, and reproductive organs. Nesfatin-1 is markedly expressed in the pancreas, stomach and duodenum. Eventually, the nesfatin-1 expression in the digestive organs may be regulated by nutritional status, which suggests a regulatory role of peripheral nesfatin-1 in energy homeostasis. Nesfatin-1is also detected in the adipose tissues of humans and rodents, indicating that nesfatin-1 expression in the fat may regulate food intake independently, rather than relying on leptin. In addition, nesfatin-1 is expressed in the heart as a cardiac peptide. It suggests that nesfatin-1 may regulate cardiac function and encourage clinical potential in the presence of nutritiondependent physio-pathologic cardiovascular diseases. Currently, only a few studies demonstrate that nesfatin-1 is expressed in the reproductive system. However, it is not clear yet what function of nesfatin-1 is in the reproductive organs. Here,we summarize the expression of nesfatin-1 and its roles in brain and peripheral organs and discuss the possible roles of nesfatin-1 expressed in reproductive organs, including testis, epididymis, ovary, and uterus. We come to the conclusion that nesfatin-1 as a local regulator in male and female reproductive organs may regulate the steroidogenesis in the testis and ovary and the physiological activity in epididymis and uterus.

Abstract

Nesfatin-1 is a recently discovered anorexigenic peptide which is distributed in several brain areas implicated in the feeding and metabolic regulation. Recently, it has been reported that nesfatin-1 is expressed not only in brain, but also in peripheral organs such as digestive organs, adipose tissues, heart, and reproductive organs. Nesfatin-1 is markedly expressed in the pancreas, stomach and duodenum. Eventually, the nesfatin-1 expression in the digestive organs may be regulated by nutritional status, which suggests a regulatory role of peripheral nesfatin-1 in energy homeostasis. Nesfatin-1is also detected in the adipose tissues of humans and rodents, indicating that nesfatin-1 expression in the fat may regulate food intake independently, rather than relying on leptin. In addition, nesfatin-1 is expressed in the heart as a cardiac peptide. It suggests that nesfatin-1 may regulate cardiac function and encourage clinical potential in the presence of nutritiondependent physio-pathologic cardiovascular diseases. Currently, only a few studies demonstrate that nesfatin-1 is expressed in the reproductive system. However, it is not clear yet what function of nesfatin-1 is in the reproductive organs. Here,we summarize the expression of nesfatin-1 and its roles in brain and peripheral organs and discuss the possible roles of nesfatin-1 expressed in reproductive organs, including testis, epididymis, ovary, and uterus. We come to the conclusion that nesfatin-1 as a local regulator in male and female reproductive organs may regulate the steroidogenesis in the testis and ovary and the physiological activity in epididymis and uterus.

참고문헌 (77)

  1. Akingbemi BT, "Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells", Endocrinology, 145, pp.592~603 (2004)
  2. Angelone T, "Nesfatin-1 as a novel cardiac peptide: identification, functional characterization, and protection against ischemia", reperfusion injury, 2012, ~
  3. Aydin S, "Nesfatin-1 and ghrelin levels in serum and saliva of epileptic patients: hormonal changes can have a major effect on seizure disorders", Mol Cell Biochem, 328, pp.49~56 (2009)
  4. Barnikol-Watanabe S, "Human protein NEFA, a novel DNA binding", EF-hand, Biol Chem Hoppe Seyler, pp.1994, 375[DOI]
  5. Bonnet MS, "Central nesfatin-1 expressing neurons are sensitive to peripheral inflammatory stimulus", J Neuroinflammation, 6, pp.27~ (2009)
  6. Brailoiu GC, "Nesfatin-1: distribution and interaction with a G protein coupled receptor in the rat brain", Endocrinology, 148, pp.5088~5094 (2007)
  7. Chen X, "Nesfatin-1 influences the excitability of glucosensing neurons in the hypothalamic nuclei and inhibits the food intake", Regul Pep, 177, pp.21~26 (2012)
  8. Dayas CV, "responses to an emotional stressor: evidence for involvement of the medial but not the central amygdala", Eur J Neurosci, 11, pp.2312~2322 (1999)
  9. Dufau ML, "Endocrine regulation and communicating functions of the Leydig cell", Annu Rev Physiol, 50, pp.483~508 (1988)
  10. Foo KS, "Nucleobindin-2", nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state, 2010, pp.204, 255~263
  11. Foo KS, "Nucleobindin-2", nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state, 2010, pp.204, 255~263
  12. Foo KS, "Distribution and neuropeptide coexistence of nucleobindin-2 mRNA", nesfatin-like immunoreactivityin the rat CNS, 2008, pp.156, 563~579
  13. Fort P, "The satiety molecule nesfatin-1 is co-expressed with melanin concentrating hormone in tuberal hypothalamic neurons of the rat", Neuroscience, 155, pp.174~181 (2008)
  14. García-Galiano D, "Expanding roles of NUCB2", nesfatin-1 in neuroendocrine regulation, 2010, pp.45, 281~290
  15. García-Galiano D, "Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2", nesfatin-1, in the testis, 2012, pp.153, 1959~1971
  16. Goebel M, "Nesfatin-1 immunoreactivity in rat brain and spinal cord autonomic nuclei", Neurosci Lett, 452, pp.241~246 (2009)
  17. Goebel M, "Restraint stress activates nesfatin-1-immunoreactive brain nuclei in rats", Brain Res, 1300, pp.114~124 (2009)
  18. Goebel M, "Localization of nesfatin-1 neurons in the mouse brain and functional implication", Brain Res, 1396, pp.20~34 (2011)
  19. Gonkowski A, "A population of nesfatin 1-like immunoreactive cells in the mucosal layer of the canine digestive tract", Res Vet Sci, 93, pp.1119~1121 (2012)
  20. Gonzalez R, "Nucleobindins: bioactive precursor proteins encoding putative endocrine factors?", Gen Comp Endocrinol, 176, pp.341~346 (2012)
  21. Gonzalez R, "Nutrient responsive nesfatin-1 regulates energy balance and induces glucose-stimulated insulin secretion in rats", Endocrinology, 152, pp.3628~3637 (2011)
  22. Gonzalez R, "Nesfatin-1 exerts a direct, glucose-dependent insulinotropic action on mouse islet beta- and MIN6 cells", Endocrinol, 208, pp.9~16 (2011)
  23. Gonzalez R, "Nesfatin-1 regulates the hypothalamo-pituitary-ovarian axis of fish", Biol Reprod, 87, pp.1~11 (2012)
  24. Gonzalez R, "Pancreatic beta cells colocalize insulin and pronesfatin immunoreactivity in rodents", Biochem Biophys Res Commun, 381, pp.643~648 (2009)
  25. Inhoff T, "Novel insight in distribution of nesfatin-1 and phospho-mTOR in the arcuate nucleus of the hypothalamus of rats", Peptides, 31, pp.257~262 (2010)
  26. Iwasaki Y, "Vagal afferents sense mealassociated gastrointestinal and pancreatic hormones: Mechanism and physiological role", Neuropeptides, 46, pp.291~297 (2012)
  27. Kaitu'u-Lino TJ, "Neutrophil depletion retards endometrial repair in a mouse model", Cell Tissue Res, 328, pp.197~206 (2007)
  28. Kanai Y, "Purification of a novel B cell growth and differentiation factor associated with lupus syndrome", Immunol Lett, 32, pp.43~48 (1992)
  29. Jinhee Kim, "Expression of Nesfatin-1", NUCB2 and Its Binding Site in Mouse Testis and Epididymis, 2011, pp.15(3), 249~256[DOI]
  30. 김진희, "17β-Estradiol에 의한 생쥐 자궁 내 Nesfatin-1", NUCB2 발현 조절, 2011, pp.15(4), 349~357[DOI]
  31. 김진희, "생쥐 난소 내 Nesfatin-1", NUCB2 발현과 결합 부위 확인, 2010, pp.14(4), 287~295[DOI]
  32. Kohno D, "Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding", Endocrinology, 149, pp.1295~1301 (2008)
  33. Kukucka Mark A, "HPLC determination of an oxytocin-like peptide produced by isolated guinea pig Leydig cells: stimulation by ascorbate", Arch Androl, 29, pp.185~190 (1992)
  34. Li QC, "Fasting plasma levels of nesfatin-1 in patients with type 1 and type 2 diabetes mellitus and the nutrientrelated fluctuation of nesfatin-1 level in normal humans", Regul Pept, 159, pp.72~77 (2010)
  35. Li Z, "mTOR-dependent modulation of gastric nesfatin-1", NUCB2, 2012, pp.29, 493~500
  36. Maejima Y, "Nesfatin-1- regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway", Cell Metab, 2009, pp.355~365 (2009)
  37. Merali Z, "Nesfatin-1 increases anxiety- and fear-related behaviors in the rat", Psychopharmacology, 201, pp.115~123 (2008)
  38. Mimee A, "Nesfatin-1 influences the excitability of neurons in the nucleus of the solitary tract and regulates cardiovascular function", Am J Physiol Regul Integr Comp Physiol, 302, pp.1297~1304 (2012)
  39. Miura K, "Molecular cloning of nucleobindin, a novel DNAbinding protein that contains both a signal peptide and a leucine zipper structure", Biochem Biophys Res Commun, 187, pp.375~380 (1992)
  40. Mohan H, "Ontogenic pattern of nucleobindin-2", nesfatin-1 expression in the gastroenteropancreatic tissues and serum of Sprague Dawleyrats, 2012, pp.175, 61~69
  41. Nakata M, "Nesfatin-1 enhances glucose-induced insulin secretion by promoting Ca2+ influx through L-type channels in mouse islet beta-cells", Endocr J, 58, pp.305~313 (2011)
  42. O¨zsavci D, "The novel function of nesfatin-1 as an anti-inflammatory and anti-apoptotic peptide in subarachnoid hemorrhageinduced oxidative brain damage in rats", Neurosurgery, 68, pp.1699~1708 (2011)
  43. Ogiso K, "Plasma nesfatin-1 concentrations in restricting-type anorexia nervosa", Peptide, 32, pp.150~153 (2011)
  44. Oh-I S, "Identification of nesfatin-1 as a satiety molecule in the hypothalamus", Nature, 443, pp.709~712 (2006)
  45. Okere B, "Restraint stress alters the secretory activity of neurons co-expressing urocortin-1, cocaine- and amphetamine-regulated transcript peptide and nesfatin-1 in the mouse Edinger-Westphal nucleus", Brain Res, 1317, pp.92~99 (2010)
  46. Osaki A, "Enhanced expression of nesfatin", nucleobindin-2 in white adipose tissue of ventromedial hypothalamus-lesioned rats, 2012, pp.521, 46~51
  47. Pałasz A, "Nesfatin-1, a unique regulatory neuropeptide of the brain", Neuropeptides, 46, pp.105~112 (2012)
  48. Price CJ, "Nesfatin-1 inhibits NPY neurons in the arcuate nucleus", Brain Res, 1230, pp.99~106 (2008)
  49. Ramanjaneya M, "Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity", Endocrinology, 151, pp.3169~3180 (2010)
  50. Shimizu H, "Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism", Endocrinology, 150, pp.662~671 (2009)
  51. Shimizu H, "Nesfatin-1: an overview and future clinical application", Endocr. J, 56, pp.537~543 (2009)
  52. Shimizu H, "A new anorexigenic protein, nesfatin-1", Peptides, 30, pp.995~998 (2009)
  53. Sonoda Y, "Physiologic regulation of postovulatory neutrophil migration into vagina in mice by a C-X-C chemokine", J Immunol, 160, pp.6159~6165 (1998)
  54. Steffl M, "Estrous cycle-dependent activity of neutrophils in the porcine endometrium: possible involvement of heat shock protein 27 and lactoferrin", Anim Reprod Sci, 121, pp.159~166 (2010)
  55. Stengel A, "Lipopolysaccharide increases gastric and circulating NUCB2", nesfatin-1 concentrations in rats, 2011, pp.32, 1942~1947
  56. Stengel A, "Nesfatin-1: a novel inhibitory regulator of food intake and body weight", Obes Rev, 12, pp.261~271 (2010)
  57. Stengel A, "Nesfatin-130-59 but not the N- and Cterminal fragments, nesfatin-11-29 and nesfatin-160- 82 injected intracerebroventricularly decreases dark phase food intake by increasing inter-meal intervals in mice", Peptides, 35, pp.143~148 (2012)
  58. Stengel A, "Central nesfatin 1 reduces darkphase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor 2 receptor", Endocrinology, 150, pp.4911~4919 (2009)
  59. Stengel A, "Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X", A-like cells: role as regulators of food intake and body weight, 2009, pp.31, 357~369
  60. Stengel A, "Abdominal surgery activates nesfatin-1 immunoreactive brain nuclei in rats", Peptides, 31, pp.263~270 (2010)
  61. Stengel A, "Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa", Endocrinology, 150, pp.232~238 (2009)
  62. Stengel A, "Nesfatin-1 - Role as possible new potent regulator of food intake", Regl Pept, 163, pp.18~23 (2010)
  63. Stengel A, "Gastric peptides and their regulation of hunger and satiety", Curr Gastroenterol Rep, 14, pp.480~488 (2012)
  64. Su Y, "The novel function of nesfatin-1: Anti-hyperglycemia", Biochem Biophys Res Commun, 391, pp.1039~1042 (2010)
  65. Tagaya Y, "Nucleobindin-2 is a positive modulator of EGF-dependent signals leading to enhancement of cell growth and suppression of adipocyte differentiation", Endocrinology, 153, pp.3308~3319 (2012)
  66. Tagaya Y, "nucleobindin-2 inhibits 3T3-L1 adipocyte differentiation", Protein Pept Lett, 19, pp.997~1004 (2012)
  67. Tang CH, "The anti-inflammatory and anti-apoptotic effects of nesfatin-1 in the traumatic rat brain", Peptides, 36, pp.39~45 (2012)
  68. Tsuchiya T, "Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males", Clin Endocrinol, 73, pp.484~490 (2010)
  69. Xia ZF, "Nesfatin-1 inhibits gastric acid secretion via a central vagal mechanism in rats", Am J Physiol Gastrointest Liver Physiol, 303, pp.570~577 (2012)
  70. Xu L, "Sex-specific effects of fasting on urocortin 1, cocaine-and amphetamine-regulated transcript peptide and nesfatin-1 expression in the rat Edinger-Westphal nucleus", Neuroscience, 162, pp.1141~1149 (2009)
  71. Xu L, "Stress-related changes in the activity of cocaine-and amphetamine-regulated transcript and nesfatin neurons in the midbrain non-preganglionic Edinger-Westphal nucleus in the rat", Neuroscience, 170, pp.478~488 (2010)
  72. Yamawaki H, "A novel adipocytokine, nesfatin-1 modulates peripheral arterial contractility and blood pressure in rats", Biochem Biophys Res Commun, 418, pp.676~681 (2012)
  73. Yang M, "Nesfatin-1 action in the brain increases insulin sensitivity through Akt", AMPK, Diabetes, pp.2012, 61[DOI]
  74. Yosten GL, "Evidence for a role of endogenous nesfatin-1 in the control of water drinking", J Neuroendocrinol, 24, pp.1078~1084 (2012)
  75. Yosten GL, "Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system", Am J Physiol Regul Integr Comp Physiol, 297, pp.330~336 (2009)
  76. Yosten GL, "The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist", Am J Physiol Regul Integr Comp Physiol, 298, pp.1642~1647 (2010)
  77. Zhang AQ, "Expression of nesfatin-1", NUCB2 in rodent digestive system, 2010, pp.16, 1735~1741

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