Nesfatin-1 as a New Potent Regulator in Reproductive System
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Nesfatin-1 is a recently discovered anorexigenic peptide which is distributed in several brain areas implicated in the feeding and metabolic regulation. Recently, it has been reported that nesfatin-1 is expressed not only in brain, but also in peripheral organs such as digestive organs, adipose tissues, heart, and reproductive organs. Nesfatin-1 is markedly expressed in the pancreas, stomach and duodenum. Eventually, the nesfatin-1 expression in the digestive organs may be regulated by nutritional status, which suggests a regulatory role of peripheral nesfatin-1 in energy homeostasis. Nesfatin-1is also detected in the adipose tissues of humans and rodents, indicating that nesfatin-1 expression in the fat may regulate food intake independently, rather than relying on leptin. In addition, nesfatin-1 is expressed in the heart as a cardiac peptide. It suggests that nesfatin-1 may regulate cardiac function and encourage clinical potential in the presence of nutritiondependent physio-pathologic cardiovascular diseases. Currently, only a few studies demonstrate that nesfatin-1 is expressed in the reproductive system. However, it is not clear yet what function of nesfatin-1 is in the reproductive organs. Here,we summarize the expression of nesfatin-1 and its roles in brain and peripheral organs and discuss the possible roles of nesfatin-1 expressed in reproductive organs, including testis, epididymis, ovary, and uterus. We come to the conclusion that nesfatin-1 as a local regulator in male and female reproductive organs may regulate the steroidogenesis in the testis and ovary and the physiological activity in epididymis and uterus.
Abstract
Nesfatin-1 is a recently discovered anorexigenic peptide which is distributed in several brain areas implicated in the feeding and metabolic regulation. Recently, it has been reported that nesfatin-1 is expressed not only in brain, but also in peripheral organs such as digestive organs, adipose tissues, heart, and reproductive organs. Nesfatin-1 is markedly expressed in the pancreas, stomach and duodenum. Eventually, the nesfatin-1 expression in the digestive organs may be regulated by nutritional status, which suggests a regulatory role of peripheral nesfatin-1 in energy homeostasis. Nesfatin-1is also detected in the adipose tissues of humans and rodents, indicating that nesfatin-1 expression in the fat may regulate food intake independently, rather than relying on leptin. In addition, nesfatin-1 is expressed in the heart as a cardiac peptide. It suggests that nesfatin-1 may regulate cardiac function and encourage clinical potential in the presence of nutritiondependent physio-pathologic cardiovascular diseases. Currently, only a few studies demonstrate that nesfatin-1 is expressed in the reproductive system. However, it is not clear yet what function of nesfatin-1 is in the reproductive organs. Here,we summarize the expression of nesfatin-1 and its roles in brain and peripheral organs and discuss the possible roles of nesfatin-1 expressed in reproductive organs, including testis, epididymis, ovary, and uterus. We come to the conclusion that nesfatin-1 as a local regulator in male and female reproductive organs may regulate the steroidogenesis in the testis and ovary and the physiological activity in epididymis and uterus.
참고문헌 (77)
- Akingbemi BT, "Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells", Endocrinology, 145, pp.592~603 (2004)
- Angelone T, "Nesfatin-1 as a novel cardiac peptide: identification, functional characterization, and protection against ischemia", reperfusion injury, 2012, ~
- Aydin S, "Nesfatin-1 and ghrelin levels in serum and saliva of epileptic patients: hormonal changes can have a major effect on seizure disorders", Mol Cell Biochem, 328, pp.49~56 (2009)
- Barnikol-Watanabe S, "Human protein NEFA, a novel DNA binding", EF-hand, Biol Chem Hoppe Seyler, pp.1994, 375[DOI]
- Bonnet MS, "Central nesfatin-1 expressing neurons are sensitive to peripheral inflammatory stimulus", J Neuroinflammation, 6, pp.27~ (2009)
- Brailoiu GC, "Nesfatin-1: distribution and interaction with a G protein coupled receptor in the rat brain", Endocrinology, 148, pp.5088~5094 (2007)
- Chen X, "Nesfatin-1 influences the excitability of glucosensing neurons in the hypothalamic nuclei and inhibits the food intake", Regul Pep, 177, pp.21~26 (2012)
- Dayas CV, "responses to an emotional stressor: evidence for involvement of the medial but not the central amygdala", Eur J Neurosci, 11, pp.2312~2322 (1999)
- Dufau ML, "Endocrine regulation and communicating functions of the Leydig cell", Annu Rev Physiol, 50, pp.483~508 (1988)
- Foo KS, "Nucleobindin-2", nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state, 2010, pp.204, 255~263
- Foo KS, "Nucleobindin-2", nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state, 2010, pp.204, 255~263
- Foo KS, "Distribution and neuropeptide coexistence of nucleobindin-2 mRNA", nesfatin-like immunoreactivityin the rat CNS, 2008, pp.156, 563~579
- Fort P, "The satiety molecule nesfatin-1 is co-expressed with melanin concentrating hormone in tuberal hypothalamic neurons of the rat", Neuroscience, 155, pp.174~181 (2008)
- García-Galiano D, "Expanding roles of NUCB2", nesfatin-1 in neuroendocrine regulation, 2010, pp.45, 281~290
- García-Galiano D, "Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2", nesfatin-1, in the testis, 2012, pp.153, 1959~1971
- Goebel M, "Nesfatin-1 immunoreactivity in rat brain and spinal cord autonomic nuclei", Neurosci Lett, 452, pp.241~246 (2009)
- Goebel M, "Restraint stress activates nesfatin-1-immunoreactive brain nuclei in rats", Brain Res, 1300, pp.114~124 (2009)
- Goebel M, "Localization of nesfatin-1 neurons in the mouse brain and functional implication", Brain Res, 1396, pp.20~34 (2011)
- Gonkowski A, "A population of nesfatin 1-like immunoreactive cells in the mucosal layer of the canine digestive tract", Res Vet Sci, 93, pp.1119~1121 (2012)
- Gonzalez R, "Nucleobindins: bioactive precursor proteins encoding putative endocrine factors?", Gen Comp Endocrinol, 176, pp.341~346 (2012)
- Gonzalez R, "Nutrient responsive nesfatin-1 regulates energy balance and induces glucose-stimulated insulin secretion in rats", Endocrinology, 152, pp.3628~3637 (2011)
- Gonzalez R, "Nesfatin-1 exerts a direct, glucose-dependent insulinotropic action on mouse islet beta- and MIN6 cells", Endocrinol, 208, pp.9~16 (2011)
- Gonzalez R, "Nesfatin-1 regulates the hypothalamo-pituitary-ovarian axis of fish", Biol Reprod, 87, pp.1~11 (2012)
- Gonzalez R, "Pancreatic beta cells colocalize insulin and pronesfatin immunoreactivity in rodents", Biochem Biophys Res Commun, 381, pp.643~648 (2009)
- Inhoff T, "Novel insight in distribution of nesfatin-1 and phospho-mTOR in the arcuate nucleus of the hypothalamus of rats", Peptides, 31, pp.257~262 (2010)
- Iwasaki Y, "Vagal afferents sense mealassociated gastrointestinal and pancreatic hormones: Mechanism and physiological role", Neuropeptides, 46, pp.291~297 (2012)
- Kaitu'u-Lino TJ, "Neutrophil depletion retards endometrial repair in a mouse model", Cell Tissue Res, 328, pp.197~206 (2007)
- Kanai Y, "Purification of a novel B cell growth and differentiation factor associated with lupus syndrome", Immunol Lett, 32, pp.43~48 (1992)
- Jinhee Kim, "Expression of Nesfatin-1", NUCB2 and Its Binding Site in Mouse Testis and Epididymis, 2011, pp.15(3), 249~256[DOI]
- 김진희, "17β-Estradiol에 의한 생쥐 자궁 내 Nesfatin-1", NUCB2 발현 조절, 2011, pp.15(4), 349~357[DOI]
- 김진희, "생쥐 난소 내 Nesfatin-1", NUCB2 발현과 결합 부위 확인, 2010, pp.14(4), 287~295[DOI]
- Kohno D, "Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding", Endocrinology, 149, pp.1295~1301 (2008)
- Kukucka Mark A, "HPLC determination of an oxytocin-like peptide produced by isolated guinea pig Leydig cells: stimulation by ascorbate", Arch Androl, 29, pp.185~190 (1992)
- Li QC, "Fasting plasma levels of nesfatin-1 in patients with type 1 and type 2 diabetes mellitus and the nutrientrelated fluctuation of nesfatin-1 level in normal humans", Regul Pept, 159, pp.72~77 (2010)
- Li Z, "mTOR-dependent modulation of gastric nesfatin-1", NUCB2, 2012, pp.29, 493~500
- Maejima Y, "Nesfatin-1- regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway", Cell Metab, 2009, pp.355~365 (2009)
- Merali Z, "Nesfatin-1 increases anxiety- and fear-related behaviors in the rat", Psychopharmacology, 201, pp.115~123 (2008)
- Mimee A, "Nesfatin-1 influences the excitability of neurons in the nucleus of the solitary tract and regulates cardiovascular function", Am J Physiol Regul Integr Comp Physiol, 302, pp.1297~1304 (2012)
- Miura K, "Molecular cloning of nucleobindin, a novel DNAbinding protein that contains both a signal peptide and a leucine zipper structure", Biochem Biophys Res Commun, 187, pp.375~380 (1992)
- Mohan H, "Ontogenic pattern of nucleobindin-2", nesfatin-1 expression in the gastroenteropancreatic tissues and serum of Sprague Dawleyrats, 2012, pp.175, 61~69
- Nakata M, "Nesfatin-1 enhances glucose-induced insulin secretion by promoting Ca2+ influx through L-type channels in mouse islet beta-cells", Endocr J, 58, pp.305~313 (2011)
- O¨zsavci D, "The novel function of nesfatin-1 as an anti-inflammatory and anti-apoptotic peptide in subarachnoid hemorrhageinduced oxidative brain damage in rats", Neurosurgery, 68, pp.1699~1708 (2011)
- Ogiso K, "Plasma nesfatin-1 concentrations in restricting-type anorexia nervosa", Peptide, 32, pp.150~153 (2011)
- Oh-I S, "Identification of nesfatin-1 as a satiety molecule in the hypothalamus", Nature, 443, pp.709~712 (2006)
- Okere B, "Restraint stress alters the secretory activity of neurons co-expressing urocortin-1, cocaine- and amphetamine-regulated transcript peptide and nesfatin-1 in the mouse Edinger-Westphal nucleus", Brain Res, 1317, pp.92~99 (2010)
- Osaki A, "Enhanced expression of nesfatin", nucleobindin-2 in white adipose tissue of ventromedial hypothalamus-lesioned rats, 2012, pp.521, 46~51
- Pałasz A, "Nesfatin-1, a unique regulatory neuropeptide of the brain", Neuropeptides, 46, pp.105~112 (2012)
- Price CJ, "Nesfatin-1 inhibits NPY neurons in the arcuate nucleus", Brain Res, 1230, pp.99~106 (2008)
- Ramanjaneya M, "Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity", Endocrinology, 151, pp.3169~3180 (2010)
- Shimizu H, "Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism", Endocrinology, 150, pp.662~671 (2009)
- Shimizu H, "Nesfatin-1: an overview and future clinical application", Endocr. J, 56, pp.537~543 (2009)
- Shimizu H, "A new anorexigenic protein, nesfatin-1", Peptides, 30, pp.995~998 (2009)
- Sonoda Y, "Physiologic regulation of postovulatory neutrophil migration into vagina in mice by a C-X-C chemokine", J Immunol, 160, pp.6159~6165 (1998)
- Steffl M, "Estrous cycle-dependent activity of neutrophils in the porcine endometrium: possible involvement of heat shock protein 27 and lactoferrin", Anim Reprod Sci, 121, pp.159~166 (2010)
- Stengel A, "Lipopolysaccharide increases gastric and circulating NUCB2", nesfatin-1 concentrations in rats, 2011, pp.32, 1942~1947
- Stengel A, "Nesfatin-1: a novel inhibitory regulator of food intake and body weight", Obes Rev, 12, pp.261~271 (2010)
- Stengel A, "Nesfatin-130-59 but not the N- and Cterminal fragments, nesfatin-11-29 and nesfatin-160- 82 injected intracerebroventricularly decreases dark phase food intake by increasing inter-meal intervals in mice", Peptides, 35, pp.143~148 (2012)
- Stengel A, "Central nesfatin 1 reduces darkphase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor 2 receptor", Endocrinology, 150, pp.4911~4919 (2009)
- Stengel A, "Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X", A-like cells: role as regulators of food intake and body weight, 2009, pp.31, 357~369
- Stengel A, "Abdominal surgery activates nesfatin-1 immunoreactive brain nuclei in rats", Peptides, 31, pp.263~270 (2010)
- Stengel A, "Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa", Endocrinology, 150, pp.232~238 (2009)
- Stengel A, "Nesfatin-1 - Role as possible new potent regulator of food intake", Regl Pept, 163, pp.18~23 (2010)
- Stengel A, "Gastric peptides and their regulation of hunger and satiety", Curr Gastroenterol Rep, 14, pp.480~488 (2012)
- Su Y, "The novel function of nesfatin-1: Anti-hyperglycemia", Biochem Biophys Res Commun, 391, pp.1039~1042 (2010)
- Tagaya Y, "Nucleobindin-2 is a positive modulator of EGF-dependent signals leading to enhancement of cell growth and suppression of adipocyte differentiation", Endocrinology, 153, pp.3308~3319 (2012)
- Tagaya Y, "nucleobindin-2 inhibits 3T3-L1 adipocyte differentiation", Protein Pept Lett, 19, pp.997~1004 (2012)
- Tang CH, "The anti-inflammatory and anti-apoptotic effects of nesfatin-1 in the traumatic rat brain", Peptides, 36, pp.39~45 (2012)
- Tsuchiya T, "Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males", Clin Endocrinol, 73, pp.484~490 (2010)
- Xia ZF, "Nesfatin-1 inhibits gastric acid secretion via a central vagal mechanism in rats", Am J Physiol Gastrointest Liver Physiol, 303, pp.570~577 (2012)
- Xu L, "Sex-specific effects of fasting on urocortin 1, cocaine-and amphetamine-regulated transcript peptide and nesfatin-1 expression in the rat Edinger-Westphal nucleus", Neuroscience, 162, pp.1141~1149 (2009)
- Xu L, "Stress-related changes in the activity of cocaine-and amphetamine-regulated transcript and nesfatin neurons in the midbrain non-preganglionic Edinger-Westphal nucleus in the rat", Neuroscience, 170, pp.478~488 (2010)
- Yamawaki H, "A novel adipocytokine, nesfatin-1 modulates peripheral arterial contractility and blood pressure in rats", Biochem Biophys Res Commun, 418, pp.676~681 (2012)
- Yang M, "Nesfatin-1 action in the brain increases insulin sensitivity through Akt", AMPK, Diabetes, pp.2012, 61[DOI]
- Yosten GL, "Evidence for a role of endogenous nesfatin-1 in the control of water drinking", J Neuroendocrinol, 24, pp.1078~1084 (2012)
- Yosten GL, "Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system", Am J Physiol Regul Integr Comp Physiol, 297, pp.330~336 (2009)
- Yosten GL, "The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist", Am J Physiol Regul Integr Comp Physiol, 298, pp.1642~1647 (2010)
- Zhang AQ, "Expression of nesfatin-1", NUCB2 in rodent digestive system, 2010, pp.16, 1735~1741
