Treatment of Verruca Vulgaris in Both External Auditory Canals Using Bleomycin Injections
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Verruca vulgaris is caused by human papillomavirus (HPV) infections. Verruca in the external auditory canal (EAC) has rarely been reported. A previous case report introduced surgical excision as a treatment for verruca in the EAC. We present a case of verruca vulgaris in both EACs that was successfully treated with an intralesional bleomycin injection. A 32-year-old male patient presented with ear fullness and palpable lumps in both EACs. Both of his canals were filled with multiple pinkish, papillomatous masses. Verruca vulgaris was confirmed by skin biopsy. An otolaryngologist referred this patient and recommended surgical excision. However, we performed intralesional bleomycin injections for treatment. Twice intralesional bleomycin injections at one-month intervals had excellent results without recurrence, ulceration or scar formation. This result indicates that bleomycin injections may prove to be an effective first-line treatment of verruca in the EAC.
Abstract
Verruca vulgaris is caused by human papillomavirus (HPV) infections. Verruca in the external auditory canal (EAC) has rarely been reported. A previous case report introduced surgical excision as a treatment for verruca in the EAC. We present a case of verruca vulgaris in both EACs that was successfully treated with an intralesional bleomycin injection. A 32-year-old male patient presented with ear fullness and palpable lumps in both EACs. Both of his canals were filled with multiple pinkish, papillomatous masses. Verruca vulgaris was confirmed by skin biopsy. An otolaryngologist referred this patient and recommended surgical excision. However, we performed intralesional bleomycin injections for treatment. Twice intralesional bleomycin injections at one-month intervals had excellent results without recurrence, ulceration or scar formation. This result indicates that bleomycin injections may prove to be an effective first-line treatment of verruca in the EAC.
참고문헌 (12)
- Androphy EJ, "Fitzpatrick’s dermatology in general medicine", pp.2421~2433 (2012), McGraw-Hill;
- Kim J, "Huge verruca vulgaris (wart) of the external auditory canal", Otolaryngol Head Neck Surg, 139(6), pp.865~866 (2008)
- Wang S, "Papillomas of the external ear canal: report of ten cases in Chinese patients with HPV in situ hybridization", Head Neck Pathol, 3(3), pp.207~211 (2009)
- Chang NC, "Squamous papilloma in the external auditory canal: a common lesion in an uncommon site", World J Clin Cases, 1(2), pp.92~95 (2013)
- Xia MY, "Ultrastructure and human papillomavirus DNA in papillomatosis of external auditory canal", Int J Dermatol, 35(5), pp.337~339 (1996)
- Sterling JC, "Handfield-Jones S, Hudson PM; British Association of Dermatologists. Guidelines for the management of cutaneous warts", Br J Dermatol, 144(1), pp.4~11 (2001)
- Saitta P, "Bleomycin in dermatology: a review of intralesional applications", Dermatol Surg, 34(10), pp.1299~1313 (2008)
- Yamamoto T, "Bleomycin and the skin", Br J Dermatol, 155(5), pp.869~875 (2006)
- Burm JS, "Intralesional Bleomycin injection for the treatment of Warts", J Korean Soc Aesthetic Plast Surg, 3(1), pp.81~87 (1997)
- Templeton SF, "bleomycin injections into normal human skin: a histopathologic and immunopathologic study", Arch Dermatol, 130(5), pp.577~583 (1994)
- James MP, "Histologic, pharmacologic, and immunocytochemical effects of injection of bleomycin into viral warts", J Am Acad Dermatol, 28(6), pp.933~937 (1993)
- Mizuno S, "Selective enhancement of bleomycin cytotoxicity by local anesthetics", Biochem Biophys Res Commun, 105(2), pp.425~431 (1982)