Efficacy of Bleomycin Intralesional Injection for Treating Digital Mucous Cysts: A Comparative Study of Corticosteroid Intralesional Injection and Surgical Excision
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Sclerotherapy has shown superior efficacy among the nonsurgical options for managing digital mucous cysts (DMC). Notably, previous research has indicated that bleomycin offers a more favorable side-effect profile and similar efficacy to conventional sclerosing agents. Objective: This study aimed to assess the efficacy and safety of bleomycin intralesional injection (ILI) for treating DMC through a comparative analysis of corticosteroid ILI and surgical excision. Methods: We retrospectively reviewed electronic medical records and clinical photographs. Telephone inter views were conducted to further investigate long-term treatment efficacy, safety, and overall treatment satisfaction. Results: Ten patients under went surgical excision, and 13 and 15 patients received bleomycin and corticosteroid ILI, respectively. Both surgical excision and bleomycin ILI demonstrated superior treatment efficacy compared to corticosteroid ILI. No statistically significant difference in the treatment effectiveness between surgical excision and bleomycin ILI was obser ved. No significant adverse effects were obser ved. In the sur vey, the level of satisfaction was the highest for bleomycin ILI, followed by surgical excision and corticosteroid ILI. Conclusion: This study revealed that bleomycin ILI exhibits a treatment efficacy higher than that of corticosteroid ILI and slightly lower than that of surgical excision, without any side effects. Therefore, bleomycin ILI is a safe and effective therapeutic option for the treatment of DMC.
Abstract
Background: Sclerotherapy has shown superior efficacy among the nonsurgical options for managing digital mucous cysts (DMC). Notably, previous research has indicated that bleomycin offers a more favorable side-effect profile and similar efficacy to conventional sclerosing agents. Objective: This study aimed to assess the efficacy and safety of bleomycin intralesional injection (ILI) for treating DMC through a comparative analysis of corticosteroid ILI and surgical excision. Methods: We retrospectively reviewed electronic medical records and clinical photographs. Telephone inter views were conducted to further investigate long-term treatment efficacy, safety, and overall treatment satisfaction. Results: Ten patients under went surgical excision, and 13 and 15 patients received bleomycin and corticosteroid ILI, respectively. Both surgical excision and bleomycin ILI demonstrated superior treatment efficacy compared to corticosteroid ILI. No statistically significant difference in the treatment effectiveness between surgical excision and bleomycin ILI was obser ved. No significant adverse effects were obser ved. In the sur vey, the level of satisfaction was the highest for bleomycin ILI, followed by surgical excision and corticosteroid ILI. Conclusion: This study revealed that bleomycin ILI exhibits a treatment efficacy higher than that of corticosteroid ILI and slightly lower than that of surgical excision, without any side effects. Therefore, bleomycin ILI is a safe and effective therapeutic option for the treatment of DMC.
참고문헌 (30)
- Sonnex TS, "Digital myxoid cysts : a review", Cutis, 37, pp.89~94 (1986)
- Pasch M, "Baran & Dawber's diseases of the nails and their man¬agement", pp.759~762 (2019), John Wiley-Blackwell
- de Berker D, "Subungual myxoid cysts : clinical manifestations and response to therapy", J Am Acad Dermatol, 46, pp.394~398 (2002)
- Kleinert HE, "Etiology and treatment of the so-called mucous cyst of the finger", J Bone Joint Surg Am, 54, pp.1455~1458 (1972)
- Jabbour S, "Management of digital mucous cysts : a systematic review and treatment algorithm", Int J Dermatol, 56, pp.701~708 (2017)
- Fritz GR, "Complications following mucous cyst excision", J Hand Surg Br, 22, pp.222~225 (1997)
- Crawford RJ, "Mucous cyst of the distal interphalangeal joint : treatment by simple excision or excision and rotation flap", J Hand Surg Br, 15, pp.113~114 (1990)
- Young KA, "The bilobed flap in treatment of mucous cysts of the distal interphalangeal joint", J Hand Surg Br, 24, pp.238~240 (1999)
- Eaton RG, "Marginal osteophyte excision in treatment of mucous cysts", J Bone Joint Surg Am, 55, pp.570~574 (1973)
- Beckenbaugh RD, "The rhomboid flap : a simple technique to cover the skin defect produced by excision of a mucous cyst of a digit", J Bone Joint Surg Br, 86, pp.932~ (2004)
- Shin EK, "Flap advancement coverage after excision of large mucous cysts", Tech Hand Up Extrem Surg, 11, pp.159~162 (2007)
- Esson GA, "Treatment of 63 subjects with digital mucous cysts with percutaneous sclerotherapy using polidocanol", Dermatol Surg, 42, pp.59~62 (2016)
- Córdoba S, "Treatment of digital mucous cysts with percutaneous sclerotherapy using polidocanol", Dermatol Surg, 34, pp.1387~1388 (2008)
- Saitta P, "Bleomycin in dermatology : a review of intralesional applications", Dermatol Surg, 34, pp.1299~1313 (2008)
- Horbach SE, "Sclerotherapy for low-flow vascular malformations of the head and neck : a systematic review of sclerosing agents", J Plast Reconstr Aesthet Surg, 69, pp.295~304 (2016)
- Helal HA, "Effect of foam and liquid bleomycin in the management of venous malformations in head and neck region : a comparative study", J Plast Reconstr Aesthet Surg, 73, pp.90~97 (2020)
- Maralcan G, "The effectiveness of intra-articular bleomycin versus methotrexate in a chronic synovitis model", Kuwait Med J, 52, pp.10~16 (2020)
- Shin K, "Percutaneous bleomycin sclerotherapy : a useful therapeutic option for ganglion cysts", Ann Dermatol, 35, pp.386~388 (2023)
- Epstein E, "A simple technique for managing digital mucous cysts", Arch Dermatol, 115, pp.1315~1316 (1979)
- Goldman JA, "Digital mucinous pseudocysts", Arthritis Rheum, 20, pp.997~1002 (1977)
- Rizzo M, "Treatment of mucous cysts of the fingers : review of 134 cases with minimum 2-year follow-up evaluation", J Hand Surg Am, 28, pp.519~524 (2003)
- Dietzek CL, "Sclerotherapy : introduction to solutions and techniques", Perspect Vasc Surg Endovasc Ther, 19, pp.317~324 (2007)
- Park SE, "Treatment of digital mucous cysts with intralesional sodium tetradecyl sulfate injection", Dermatol Surg, 40, pp.1249~1254 (2014)
- Sung JY, "Efficacy and safety of sclerotherapy for digital mucous cysts", J Dermatolog Treat, 25, pp.415~418 (2014)
- Umezawa H, "Purification of bleomycins", J Antibiot(Tokyo), 19, pp.210~215 (1966)
- Yura J, "Bleomycin treatment for cystic hygroma in children", Nippon Geka Hokan, 46, pp.607~614 (1977)
- Blum RH, "A clinical review of bleomycin--a new antineoplastic agent", Cancer, 31, pp.903~914 (1973)
- Muggia FM, "Pulmonary toxicity of antitumor agents", Cancer Treat Rev, 10, pp.221~243 (1983)
- Muir T, "Intralesional bleomycin injection(IBI)treatment for haemangiomas and congenital vascular malformations", Pediatr Surg Int, 19, pp.766~773 (2004)
- Jung JW, "Clinical type and treatment response in patients with digital mucous cyst : a retrospective study", Korean J Dermatol, 59, pp.742~748 (2021)