Two Cases of Multiple Epidermolytic Acanthomas Mimicking Verruca Vulgaris
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Epidermolytic acanthoma (EA) is a rare benign tumor, which usually appears as a solitary small papule. However, there are a few case reports of multiple EA, most of which occurs on the genital area. Cases of multiple EA may mimic verruca vulgaris, condyloma accuminatum, seborrheic keratosis, and bowenoid papulosis, and therefore, can be easily misdiagnosed. A 78-year-old male presented with a 2-week history of discrete, small skin-colored papules around the anus. The other case involved a 47-year-old male with a 5-year history of skin-colored papules on the scrotum. Skin biopsy of both cases revealed a well-demarcated papular lesion characterized by compact hyperkeratosis, perinuclear vacuolization, and reticular degeneration in the granular and upper spinous layer with coarse basophilic keratohyalin granules. Epidermal invagination was consistent with a cup-shaped type of EA. Both cases tested negative for human papillomavirus. We report typical cases of multiple EA, which should be considered as the differential diagnosis of small skin-colored papules in the anogenital area, to prevent the misdiagnosis.
Abstract
Epidermolytic acanthoma (EA) is a rare benign tumor, which usually appears as a solitary small papule. However, there are a few case reports of multiple EA, most of which occurs on the genital area. Cases of multiple EA may mimic verruca vulgaris, condyloma accuminatum, seborrheic keratosis, and bowenoid papulosis, and therefore, can be easily misdiagnosed. A 78-year-old male presented with a 2-week history of discrete, small skin-colored papules around the anus. The other case involved a 47-year-old male with a 5-year history of skin-colored papules on the scrotum. Skin biopsy of both cases revealed a well-demarcated papular lesion characterized by compact hyperkeratosis, perinuclear vacuolization, and reticular degeneration in the granular and upper spinous layer with coarse basophilic keratohyalin granules. Epidermal invagination was consistent with a cup-shaped type of EA. Both cases tested negative for human papillomavirus. We report typical cases of multiple EA, which should be considered as the differential diagnosis of small skin-colored papules in the anogenital area, to prevent the misdiagnosis.
참고문헌 (20)
- Ji-Hye Yang, "Isolated Epidermolytic Acanthoma in a Renal Transplant Recipient", Annals of Dermatology, 23(3), pp.415~416 (2011), 대한피부과학회
- Roy SF, "Solitary and multiple epidermolytic acanthoma : a demographic and clinical study of 131 cases", J Cutan Pathol, 46, pp.305~309 (2019)
- Abbas O, "Solitary epidermolytic acanthoma : a clinical and histopathological study", J Eur Acad Dermatol Venereol, 25, pp.175~180 (2011)
- Fletcher JW, "Presentation of epidermolytic acanthomas as multiple tan papules on the vulva", Proc(Bayl Univ Med Cent), 29, pp.198~199 (2016)
- Behera B, "Dermoscopy of a solitary verrucous plaque on the back", J Am Acad Dermatol, 77, pp.e37~e39 (2017)
- Braun RP, "Dermoscopy of pigmented seborrheic keratosis : a morphological study", Arch Dermatol, 138, pp.1556~1560 (2002)
- Zalaudek I, "Entodermoscopy : a new tool for diagnosing skin infections and infestations", Dermatology, 216, pp.14~23 (2008)
- Lee TJ, "Multiple epidermolytic acanthomas mimicking condyloma : a retrospective study of 8 cases", Int J Dermatol, 57, pp.28~33 (2018)
- Grayson W, "McKee’s pathology of the skin", pp.760~895 (2012), Elsevier
- Xu X, "Lever's histopathology of the skin", pp.781~815 (2015), Wolters Kluwer
- Shapiro L, "Isolated epidermolytic acanthoma. A solitary tumor showing granular degeneration", Arch Dermatol, 101, pp.220~223 (1970)
- Cohen PR, "Epidermolytic acanthomas : clinical characteristics and immunohistochemical features", Am J Dermatopathol, 19, pp.232~241 (1997)
- 정준민, "A Case of Multiple Epidermolytic Acanthoma of the Scrotum: Is the Human Papillomavirus a Culprit?", Annals of Dermatology, 27(5), pp.633~634 (2015), 대한피부과학회
- Leonardi C, "Epidermolytic acanthoma does not contain human papillomavirus DNA", J Cutan Pathol, 18, pp.103~105 (1991)
- Kazlouskaya V, "Solitary epidermolytic acanthoma", J Cutan Pathol, 40, pp.701~707 (2013)
- Egozi-Reinman E, "Epidermolytic acanthoma of the genitalia does not show mutations in KRT1 or KRT10", Am J Dermatopathol, 38, pp.164~165 (2016)
- Sánchez-Carpintero I, "Disseminated epidermolytic acanthoma probably related to trauma", Br J Dermatol, 141, pp.728~730 (1999)
- Kukreja T, "Multiple epidermolytic acanthomas must not be confused with genital human papillomavirus infection", Acta Derm Venereol, 89, pp.169~171 (2009)
- Jang BS, "Multiple scrotal epidermolytic acanthomas successfully treated with topical imiquimod", J Dermatol, 34, pp.267~269 (2007)
- Moulonguet I, "Multiple epidermolytic acanthomas of the genitalia", Ann Dermatol Venereol, 144, pp.295~300 (2017)