혈청 나트륨 농도가 열성 경련의 발생 및 재발에 미치는 영향
The Effects of Serum Sodium Concentration on Occurrence and Recurrence of Febrile Seizures
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목적: 환자-대조군 연구를 통하여 혈청 나트륨 농도가 열성 경련의 발생 및 재발에 미치는 영향에 대하여 연구하고자 하였다. 방법: 2014년 1월 1일부터 2016년 2월 29일까지 동국대학교 경주병원에서 입원치료를 받은 6개월 이상에서 5세 미만의 열성 경련 환자 150명과 경련 없이 발열만 있었던 환자 150명에 대해 후향적으로의무 기록지를 조사하였다. 환자군 및 대조군의 연령, 성별 및 혈청 나트륨 농도를 비교하였고 환자군을 단순 대 복합 열성 경련군, 비반복성 대 반복성 열성 경련군, 비재발성 대 재발성 열성 경련군으로 나누어 각 그룹의 혈청 나트륨 농도를 통계적으로 분석하였다. 결과: 환자군의 평균 혈청 나트륨 농도(137.46±2.72 mmol/L)는대조군의 혈청 나트륨 농도(139.34±2.14 mmol/L)에 비해 유의하게낮았다(P<0.05). 단순 열성 경련군의 혈청 나트륨 농도(137.47±2.53 mmol/L)는 복합 열성 경련군의 혈청 나트륨 농도(137.43±3.77 mmol/L)와 유의한 차이가 없었다(P=0.998). 반복성 열성 경련군의혈청 나트륨 농도(136.56±3.2 mmol/L)는 비반복성 열성 경련군의혈청 나트륨 농도(137.56±2.66 mmol/L)보다 더 낮았으나 통계적으로 유의하지는 않았다(P=0.272). 재발성 열성 경련군의 혈청 나트륨농도(136.6±2.02 mmol/L)는 비재발성 열성 경련군의 혈청 나트륨농도(137.89±2.93 mmol/L)에 비하여 유의하게 낮았다(P=0.006). 환자군의 모든 하위 그룹들의 혈청 나트륨 농도는 대조군에 비해 유의하게 낮았다. 결론: 낮은 혈청 나트륨 농도는 열성 경련의 발생 및 재발의 증가에영향을 주는 것으로 판단된다.
Abstract
Purpose: The aim of this study is to elucidate the effects of serum sodium concentration on occurrence and recurrence of febrile seizures based on case-control study. Methods: We reviewed retrospectively clinical records of 150 inpatients with febrile seizures and 150 inpatients with febrile illness without seizure aged from 6 months to 5 years in the Pediatric Department of Dongguk University Gyeongju Hospital between January 2014 and February 2016. The age, sex and serum sodium concentration of the patient group were compared with those of control group. Patient group was divided into simple vs complex febrile seizure group, non-repeated vs repeated febrile seizure group, non-recurrent vs recurrent febrile seizure group, and the serum sodium concentration of each group were analysed statistically. Results: The mean serum sodium concentration (137.46±2.72 mmol/L) of patient group was significantly lower (P<0.05) than that of control group (139.34±2.14 mmol/L). The mean serum sodium concentration of simple febrile seizure group (137.47±2.53 mmol/L) was not significantly different (P=0.998) from that of complex febrile seizure group (137.43±3.77 mmol/L). The mean serum sodium concentration of repeated febrile seizure group (136.56±3.2 mmol/L) was lower than that of non-repeated febrile seizure group (137.56±2.66 mmol/L), but not significant (P= 0.272). The mean serum sodium concentration of recurrent febrile seizure group (136.60±2.02 mmol/L) was significantly lower (P=0.006) than that of non-recurrent febrile seizure group (137.89±2.93 mmol/L). The mean serum sodium concentration of all these subgroups were significantly lower than that of control group. Conclusion: Low serum sodium concentration may have an effect on the increase of occurrence and recurrence of febrile seizures.
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