심부 각막 궤양 및 천공 환자에서 시행한 다섯 겹 강화형 양막 이식술
Five-Layered Reinforcing Amniotic Membrane Transplantation for Treatment of Deep Corneal Ulcer or Perforation
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목적: 심부 각막 궤양 및 각막 천공 환자에서 다섯 겹 강화형 양막 이식술을 시행하여 그 유용성과 임상결과를 알아보고자 하였다. 증례요약: 동결 건조 처리된 5장의 양막의 기계적 압착과정을 통해 제작된 다섯 겹 강화형 양막을 이용하여 2 mm 이상 크기의 각막궤양 및 각막천공 환자 3명 3안에게 이식하여 봉합하고 1년 이상 경과 관찰하였다. 강화형 양막 이식을 시행 받은 모든 환자에서 2주이내의 각막상피화가 이루어졌고 1년 이상 안구표면의 안정화가 유지되는 것이 관찰되었다. 결론: 수술 시간의 단축 및 보관의 용이성을 가지는 다섯 겹 강화형 양막 이식술은 응급 각막 이식이 어려운 각막궤양 및 천공환자에서합병증 없이 치유할 수 있는 효과적인 치료법이다.
Abstract
Purpose: To evaluate the efficacy of five-layered reinforced amniotic membrane (AM) transplantation for treating deep corneal ulcer or perforation. Case summary: We performed a five-layered reinforced AM transplant in three cases of corneal ulceration or perforation using mechanical compressed lyophilized AMs. In all cases, the perforated cornea healed with re-epithelization within 2weeks and the ocular surface was stabilized for more than 1 year. Conclusions: Five-layered reinforced AM transplantation may be an alternative method for treating deep corneal ulcers or perforations.
참고문헌 (18)
- Kenyon KR, "Inflammatory mechanisms in corneal ulceration", Trans Am Ophthalmol Soc, 83, pp.610~663 (1985)
- Prabhasawat P, "Single and multilayer amniotic membrane transplantation for persistent corneal epithelial defect with and without stromal thinning and perforation", Br J Ophthalmol, 85, pp.1455~1463 (2001)
- Kim JC, "Amniotic membrane transplantation in perforation or impending perforation of cornea", J Korean Ophthalmol Soc, 40, pp.1487~1495 (1999)
- Portnoy SL, "Surgical management of corneal ulceration and perforation", Surv Ophthalmol, 34, pp.47~58 (1989)
- Bernauer W, "The management of corneal perforations associated with rheumatoid arthritis", Ophthalmology, 102, pp.1325~1337 (1995)
- Abel R Jr, "The results of penetrating keratoplasty after chemical burns", Trans Am Acad Ophthalmol Otolaryngol, 79, pp.584~595 (1975)
- Azuara-Blanco A, "Amniotic membrane transplantation for ocular surface reconstruction", Br J Ophthalmol, 83, pp.399~402 (1999)
- Tseng SC, "Amniotic membrane transplantation with or without limbal allografts for corneal surface reconstruction in patients with limbal stem cell deficiency", Arch Ophthalmol, 116, pp.431~441 (1998)
- Shimazaki J, "Transplantation of amniotic membrane and limbal autograft for patients with recurrent pterygium associated with symblepharon", Br J Ophthalmol, 82, pp.235~240 (1998)
- Talmi YP, "Use of human amniotic membrane as a biologic dressing", Eur J Plast Surg, 13, pp.160~162 (1990)
- Rodríguez-Ares MT, "Multilayer amniotic membrane transplantation in the treatment of corneal perforations", Cornea, 23, pp.577~583 (2004)
- Ma DH, "Amniotic membrane graft for the management of scleral melting and corneal perforation in recalcitrant infectious scleral and corneoscleral ulcers", Cornea, 21, pp.275~283 (2002)
- Hanada K, "Multilayered amniotic membrane transplantation for severe ulceration of the cornea and sclera", Am J Ophthalmol, 131, pp.324~331 (2001)
- Prabhasawat P, "Single and multilayer amniotic membrane transplantation for persistent corneal epithelial defect with and without stromal thinning and perforation", Br J Ophthalmol, 85, pp.1455~1463 (2001)
- Dekaris I, "Multilayer vs. monolayer amniotic membrane transplantation for deep corneal ulcer treatment", Coll Antropol, 25, pp.23~28 (2001)
- Tsubota K, "Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome", Am J Ophthalmol, 122, pp.38~52 (1996)
- 안용석, "각막궤양천공에서의 다층양막이식술", 대한안과학회지, 44(6), pp.8~1296 (2003), 대한안과학회
- Nubile M, "In vivo analysis of stromal integration of multilayer amniotic membrane transplantation in corneal ulcers", Am J Ophthalmol, 151, pp.809~822 (2011)