천공된 세균성 각막염에서 목시플록사신 함유 강화양막이식술의 임상적 적용 2예
Moxifloxacin Mixed Augmented Amniotic Membrane Transplantation for Perforating Infectious Keratitis
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
목적: 두 명의 천공된 세균성 각막염 환자의 일차적 치료로 이용된 목시플록사신 함유 강화 양막이식술의 치료효과를 보고하고자 한다. 증례요약: 세균성 각막염이 급속히 진행되어 각막천공이 발생한 두 명의 환자를 대상으로 목시플록사신 함유 강화양막이식술을 시행하였다. 두 증례에서 모두 전방은 잘 유지되었으며, 수술 후 한 달 이내에 완전한 각막상피재생이 관찰되었고, 3개월의 추적관찰기간동안 감염의 재발 소견은 보이지 않았다. 결론: 급속하게 진행되는 활동성 세균성 각막염으로 인해 각막이 천공된 경우, 목시플록사신 함유 강화양막이식술은 각막천공과 감염억제의 동시에 치료할 수 있는 일차적인 방법으로 유용할 것으로 생각한다.
Abstract
Purpose: To report the clinical results of moxifloxacin mixed augmented amniotic membrane transplantation (AMT) in 2patients with perforating infectious keratitis. Case summary: Moxifloxacin mixed augmented amniotic membrane transplantations were performed in 2 patients with rapidly deteriorating deep perforated bacterial keratitis. All patients preserved their eyesight. Complete re-epithelization over the amniotic membrane were observed within a month. The corneal surfaces were healed with opacity, and there were no active infectious infiltrations or recurrences for 3 months after application. Conclusions: Moxifloxacin mixed augmented AMT has proven to be successful both tectonically and physiologically for cases with perforating active bacterial keratitis.
참고문헌 (19)
- Bessant DA, "Lamellar keratoplasty in the management of inflammatory corneal ulceration and perforation", Eye, 8, pp.22~28 (1994)
- Nobe JR, "Results of penetrating keratoplasty for the treatment of corneal perforations", Arch Ophthalmol, 108, pp.939~941 (1990)
- Kim JC, "Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas", Cornea, 14, pp.473~484 (1995)
- Kruse FE, "Multilayer amniotic membrane transplantation for reconstruction of deep corneal ulcers", Ophthalmology, 106, pp.1504~1510 (1999)
- 오종현, "독성표피괴사융해증 환자에서 비감염성 각막궤양에 의한 각막천공 1예", 대한안과학회지, 47(11), pp.1829~1833 (2006), 대한안과학회
- Kim HK, "Fibrin glue-assisted augmented amniotic membrane transplantation for the treatment of large noninfectious corneal perforations", Cornea, 28, pp.170~176 (2009)
- Xu JJ, "The effects of amniotic membrane on corneal penetration of ofloxacin", Zhonghua Yan Ke Za Zhi, 42, pp.624~627 (2006)
- 이상윤, "괴사성 공막염으로 안내염이 발생하여 유리체절제술 및 영구양막이식술로 치료한 1예 보고", 대한안과학회지, 52(1), pp.97~102 (2011), 대한안과학회
- Hick S, "Amniotic membrane transplantation and fibrin glue in the management of corneal ulcers and perforations: a review of 33 cases", Cornea, 24, pp.369~377 (2005)
- Rodríguez-Ares MT, "Multilayer amniotic membrane transplantation in the treatment of corneal perforations", Cornea, 23, pp.577~583 (2004)
- Koranyi G, "Cut and paste: a no suture, small incision approach to pterygium surgery", Br J Ophthalmol, 88, pp.911~914 (2004)
- Duchesne B, "Use of human fibrin glue and amniotic membrane transplant in corneal perforation", Cornea, 20, pp.230~232 (2001)
- Kim JS, "Amniotic membrane patching promotes healing and inhibits proteinase activity on wound healing following acute corneal alkali burn", Exp Eye Res, 70, pp.329~337 (2000)
- Wang MX, "Reduction in corneal haze and apoptosis by amniotic membrane atrix in excimer laser photoablation in rabbits", J Cataract Refract Surg, 27, pp.310~319 (2001)
- Lambiase A, "Amniotic membrane transplantation associated with conjunctival peritomy in the management of Mooren’s ulcer: a case report", Eur J Ophthalmol, 15, pp.274~276 (2005)
- Kjaergaard N, "Antibacterial properties of human amnion and chorion in vitro", Eur J Obstet Gynecol Reprod Biol, 94, pp.224~229 (2001)
- Kjaergaard N, "Chorioamniotic membranes constitute a competent barrier to group B Streptococcus in vitro", Eur J Obstet Gynecol Reprod Biol, 83, pp.165~169 (1999)
- Kim HS, "Amniotic membrane, tear film, corneal, and aqueous levels of ofloxacin in rabbit eyes after amniotic membrane transplantation", Cornea, 20, pp.628~634 (2001)
- Kowalski RP, "Intracameral Vigamox (moxifloxacin 0.5%) is non-toxic and effective in preventing endophthalmitis in a rabbit model", Am J Ophthalmol, 140, pp.497~504 (2005)