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거짓비늘증후군의 중심각막두께 및 각막내피세포에 대한 분석

Central Corneal Thickness and Corneal Endothelial Cells in Pseudoexfoliation Syndrome

박정현|김태진|백동원|하효신|장인범
대한안과학회 (The Korean Ophthalmological Society)|2013.07|대한안과학회지 (Journal of The Korean Ophthalmological Society)|제54권 제7호|pp. 1060-1065

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키워드

Central corneal thicknessCorneal curvaturePseudoexfoliation syndromeCorneal endothelial cell density
주제분류안과학

초록

목적: 거짓비늘증후군 환자의 중심각막두께 및 각막내피세포에 대해 알아보고자 하였다. 대상과 방법: 백내장 수술 전 검사 또는 녹내장 정밀검사를 받은 환자 중 거짓비늘증후군으로 진단된 44명(59안)을 대상으로 하였으며,나이와 성별의 차이가 없는 대조군을 설정하여 안압, 중심각막두께, 각막내피세포의 밀도, 각막곡률, 안축장을 비교하였다. 결과: 거짓비늘증후군 환자는 정상대조군보다 높은 안압(p=0.001) 과 얇은 중심각막두께(p=0.003), 낮은 각막내피세포의 밀도를 나타내었다(p=0.037). 단순거짓비늘증후군 환자에서는 정상대조군보다 얇은 중심각막두께(p=0.010)와 낮은 밀도의 각막내피세포(p=0.041)를 관찰할 수 있었지만 안압은 유의한 차이를 보이지 않았다(p=0.941). 녹내장병합군은 정상대조군과 차이가 없는 중심각막두께(p=0.060)와 각막내피세포의 밀도(p=0.171)를 보였지만 안압이 유의하게 높은 것을 관찰할 수 있었다(p˂0.001). 결론: 거짓비늘증후군, 특히 녹내장이 병합되지 않은 환자군에서 중심각막두께가 다소 얇게 나타나 이들 환자군에서 안압 수치의 분석및 녹내장의 진단에 주의를 기울여야 할 것으로 생각한다.

Abstract

Purpose: To evaluate the central corneal thickness (CCT) and corneal endothelial cell density (ENDO) in pseudoexfoliation syndrome. Methods: Medical records of patients who underwent a preoperative examination for cataract surgery and an examination for glaucoma were retrospectively reviewed. The present study included 44 patients (59 eyes) and age- and sex-matched controls. The total pseudoexfoliation patients divided into 2 groups, such as pseudoexfoliation syndrome (28 eyes) and pseudoexfoliative glaucoma (21 eyes) .The intraocular pressure (IOP), CCT, ENDO, corneal curvature (CC) and axial length (AL) were measured. Results: The total pseudoexfoliation group showed significantly higher IOP (p = 0.001), thinner CCT (p = 0.003) and lower ENDO (p = 0.037). The pseudoexfoliation syndrome group showed significantly thinner CCT (p = 0.010) and lower EDNO (p = 0.041), but no significant difference in IOP (p = 0.941). There was no significant difference in CCT (p = 0.060) and ENDO (p = 0.171) between the pseudoexfoliative glaucoma group and controls, but the pseudoexfolliative glaucoma group showed significantly higher IOP (p < 0.001). Conclusions: The pseudoexfoliation group showed thinner CCT which should be taken into consideration when evaluating IOP with the applanation tonometer and diagnosing glaucoma, especially in pseudoexfoliation syndrome patients.

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