The Relationship between Higher-order Aberrations and Amblyopia Treatment in Hyperopic Anisometropic Amblyopia
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Purpose: To investigate the relationship between higher-order aberrations (HOAs) and amblyopia treatment inchildren with hyperopic anisometropic amblyopia. Methods: The medical records of hyperopic amblyopia patients with both spherical anisometropia of 1.00 diopter(D) or more and astigmatic anisometropia of less than 1.00 D were reviewed retrospectively. Based on theresults of the amblyopia treatment, patients were divided into two groups: treatment successes and failures. Using the degree of spherical anisometropia, subjects were categorized into mild, moderate, or severe groups. Ocular, corneal, and internal HOAs were measured using a KR-1W aberrometer at the initial visit, and at3-month, 6-month, and 12-month follow-ups. Results: The results of the 45 (21 males and 24 females) hyperopic anisometropic amblyopia patients whocompleted the 12-month follow-up examinations were analyzed. The mean patient age at the initial visit was70.3 months. In total, 28 patients (62.2%) had successful amblyopia treatments and 17 patients (37.8%) failedtreatment after 12 months. Among the patient population, 24 (53.3%) had mild hyperopic anisometropia and 21(46.7%) had moderate hyperopic anisometropia. When comparing the two groups (i.e., the success and failuregroups), ocular spherical aberrations and internal spherical aberrations in the amblyopic eyes were significantlyhigher in the failure group at every follow-up point. There were no significant differences in any of the HOAsbetween mild and moderate cases of hyperopic anisometropia at any follow-up. When the amblyopic and felloweyes were compared between the groups there were no significant differences in any of the HOAs. Conclusions: HOAs, particularly ocular spherical aberrations and internal spherical aberrations, should be consideredas reasons for failed amblyopia treatment.
Abstract
Purpose: To investigate the relationship between higher-order aberrations (HOAs) and amblyopia treatment inchildren with hyperopic anisometropic amblyopia. Methods: The medical records of hyperopic amblyopia patients with both spherical anisometropia of 1.00 diopter(D) or more and astigmatic anisometropia of less than 1.00 D were reviewed retrospectively. Based on theresults of the amblyopia treatment, patients were divided into two groups: treatment successes and failures. Using the degree of spherical anisometropia, subjects were categorized into mild, moderate, or severe groups. Ocular, corneal, and internal HOAs were measured using a KR-1W aberrometer at the initial visit, and at3-month, 6-month, and 12-month follow-ups. Results: The results of the 45 (21 males and 24 females) hyperopic anisometropic amblyopia patients whocompleted the 12-month follow-up examinations were analyzed. The mean patient age at the initial visit was70.3 months. In total, 28 patients (62.2%) had successful amblyopia treatments and 17 patients (37.8%) failedtreatment after 12 months. Among the patient population, 24 (53.3%) had mild hyperopic anisometropia and 21(46.7%) had moderate hyperopic anisometropia. When comparing the two groups (i.e., the success and failuregroups), ocular spherical aberrations and internal spherical aberrations in the amblyopic eyes were significantlyhigher in the failure group at every follow-up point. There were no significant differences in any of the HOAsbetween mild and moderate cases of hyperopic anisometropia at any follow-up. When the amblyopic and felloweyes were compared between the groups there were no significant differences in any of the HOAs. Conclusions: HOAs, particularly ocular spherical aberrations and internal spherical aberrations, should be consideredas reasons for failed amblyopia treatment.
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