Comparison of Injection of Intravitreal Drugs with Standard Care in Macular Edema Secondary to Branch Retinal Vein Occlusion
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Purpose: To compare the long-term efficacy and safety of intravitreal triamcinolon with or without rescue lasertherapy (intravitreal triamcinolone injection [IVTA] group), bevacizumab with or without rescue laser treatment(intravitreal bevacizumab injection [IVB] group), or a combination of both with or without rescue laser therapy(IVTA + IVB group), with standard care for patients with macular edema secondary to branch retinal vein occlusion(BRVO). Methods: We reviewed the medical records of 151 patients treated with intravitreal injection with or without rescuelaser for treatment of macular edema caused by BRVO, and who were followed up at 1, 3, 6, 12, and 24months. During the observation period, rescue grid laser or repeated intravitreal injection with initial drug wasperformed if recurrence of macular edema was confirmed. Visual acuity, change in visual acuity, and intraocularpressure were compared in each phase. Results: Totals of 16%, 5.6%, and 0% of participants in the three groups showed significant visual loss of morethan three lines of the Snellen chart at last follow-up. The IVTA group was the least effective treatment modality,with statistical significance. The development rates of elevated intraocular pressure were similar among thegroups. Conclusions: Although IVTA yielded effects similar to those of standard grid photocoagulation based on theStandard Care vs Corticosteroid for Retinal Vein Occlusion study, IVB or IVTA + IVB with or without rescuelaser treatment resulted in improvement in visual acuity at 24 months after the start of treatment and was associatedwith few serious adverse side effects. Thus, these approaches could be useful for treating macularedema arising secondary to BRVO.
Abstract
Purpose: To compare the long-term efficacy and safety of intravitreal triamcinolon with or without rescue lasertherapy (intravitreal triamcinolone injection [IVTA] group), bevacizumab with or without rescue laser treatment(intravitreal bevacizumab injection [IVB] group), or a combination of both with or without rescue laser therapy(IVTA + IVB group), with standard care for patients with macular edema secondary to branch retinal vein occlusion(BRVO). Methods: We reviewed the medical records of 151 patients treated with intravitreal injection with or without rescuelaser for treatment of macular edema caused by BRVO, and who were followed up at 1, 3, 6, 12, and 24months. During the observation period, rescue grid laser or repeated intravitreal injection with initial drug wasperformed if recurrence of macular edema was confirmed. Visual acuity, change in visual acuity, and intraocularpressure were compared in each phase. Results: Totals of 16%, 5.6%, and 0% of participants in the three groups showed significant visual loss of morethan three lines of the Snellen chart at last follow-up. The IVTA group was the least effective treatment modality,with statistical significance. The development rates of elevated intraocular pressure were similar among thegroups. Conclusions: Although IVTA yielded effects similar to those of standard grid photocoagulation based on theStandard Care vs Corticosteroid for Retinal Vein Occlusion study, IVB or IVTA + IVB with or without rescuelaser treatment resulted in improvement in visual acuity at 24 months after the start of treatment and was associatedwith few serious adverse side effects. Thus, these approaches could be useful for treating macularedema arising secondary to BRVO.
참고문헌 (16)
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