Comparison of the Thickness and Volume of the Macula and Fovea in Patients with Anisometropic Amblyopia Prior to and after Occlusion Therapy
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To compare the thickness of superior, temporal, inferior, and nasal macula and foveal thickness andvolume in patients with anisometropic amblyopia prior to and after successful occlusion therapy using opticalcoherence tomography (OCT) measurement. Methods: Data were collected prospectively on 30 patients with unilateral anisometropic amblyopia fromDecember 2006 to August 2007. All patients had anisometropia of 2.0 diopters or more. OCT scans wereobtained for all patients at diagnosis. Occlusion therapy was then prescribed and OCT scans were obtainedagain at the time of successful occlusion therapy (defined as interocular difference of <0.1 log units). TheStratus OCT-3 was used to measure fovea thickness and volume and the thickness of superior, temporal,inferior, and nasal macula (within a diameter of 3 mm). Results: Of 30 patients, 22 (mean age of 5.8 years) had successful resolution of amblyopia. The mean durationof occlusion was 11.24 months and mean best-corrected visual acuity at diagnosis was 0.35 ± 0.12 logarithmof the minimum angle of resolution. The mean thicknesses of the superior, temporal, inferior, and nasalmacula prior to and after occlusion were not significantly different (p > 0.05). However, mean foveal volumeprior to occlusion therapy (0.15 ± 0.02 mm3) decreased after occlusion (0.14 ± 0.01 mm3) with statistical significance(Wilcoxon signed rank test, p = 0.025). Conclusions: There was a meaningful decrease in foveal volume in patients with anisometropic amblyopia aftersuccessful occlusion therapy. Whether this decrease relates to visual improvement of the amblyopic eyeremains to be determined. Key Words: Anisometropic amblyopia, Foveal
Abstract
To compare the thickness of superior, temporal, inferior, and nasal macula and foveal thickness andvolume in patients with anisometropic amblyopia prior to and after successful occlusion therapy using opticalcoherence tomography (OCT) measurement. Methods: Data were collected prospectively on 30 patients with unilateral anisometropic amblyopia fromDecember 2006 to August 2007. All patients had anisometropia of 2.0 diopters or more. OCT scans wereobtained for all patients at diagnosis. Occlusion therapy was then prescribed and OCT scans were obtainedagain at the time of successful occlusion therapy (defined as interocular difference of <0.1 log units). TheStratus OCT-3 was used to measure fovea thickness and volume and the thickness of superior, temporal,inferior, and nasal macula (within a diameter of 3 mm). Results: Of 30 patients, 22 (mean age of 5.8 years) had successful resolution of amblyopia. The mean durationof occlusion was 11.24 months and mean best-corrected visual acuity at diagnosis was 0.35 ± 0.12 logarithmof the minimum angle of resolution. The mean thicknesses of the superior, temporal, inferior, and nasalmacula prior to and after occlusion were not significantly different (p > 0.05). However, mean foveal volumeprior to occlusion therapy (0.15 ± 0.02 mm3) decreased after occlusion (0.14 ± 0.01 mm3) with statistical significance(Wilcoxon signed rank test, p = 0.025). Conclusions: There was a meaningful decrease in foveal volume in patients with anisometropic amblyopia aftersuccessful occlusion therapy. Whether this decrease relates to visual improvement of the amblyopic eyeremains to be determined. Key Words: Anisometropic amblyopia, Foveal
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