스펙트럼영역 빛간섭단층촬영으로 측정한 당뇨망막병증 환자의 주변부 맥락막두께 측정
Choroidal Thickness at the Outside of Fovea in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography
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목적: 스펙트럼영역 빛간섭단층촬영을 이용하여 당뇨망막병증 환자에서 중심와 및 혈관궁 근처의 주변부 맥락막두께를 측정하여 당뇨망막병증의 중증도에 따른 차이를 알아보고자 하였다. 대상과 방법: 정상 40안, 당뇨망막병증 87안을 대상으로 Heidelberg Spectralis® EDI mode를 이용하여 맥락막두께를 측정하였다. 당뇨망막병증 87안은 당뇨망막병증의 중증도와 황반부종의 유무에 따라 3개의 군으로 분류하였다. 맥락막두께는 중심와 주위뿐만 아니라 혈관궁 근처의 주변부를 측정하였으며, 1개의 중심와 주위와 8개의 주변부 이미지를 선택하여 맥락막두께를 비교하였다. 결과: 중심와 아래의 맥락막두께는 당뇨망막병증의 중증도가 심해질수록 얇아지는 경향을 보였으나 통계학적으로 유의한 차이를 보이지는 않았다. 혈관궁 근처의 주변부 맥락막두께 중 상이측의 맥락막두께가 의미 있는 차이를 보였다. 결론: 중심와 및 혈관궁 근처의 주변부 맥락막두께는 당뇨망막병증의 중중도가 심해질수록 얇아지는 경향을 보였으며, 상이측의 주변부에서 두드러진 것을 알 수 있었다.
Abstract
Purpose: To evaluate choroidal thickness at the outside of the fovea in patients with diabetic retinopathy using spectral-domain optical coherence tomography. Methods: We examined 87 eyes of 87 patients with diabetic retinopathy and 40 eyes of 40 normal patients. Patients with diabetic retinopathy were divided into 3 groups according to the grade of diabetic retinopathy and macular edema. The choroidal thickness was obtained at the fovea and outside of the fovea using enhanced depth imaging of Spectralis optical coherence tomography. One foveal and 8 peripheral images were selected and choroidal thickness was measured from the outer border of the retinal pigment epithelium to the inner scleral border. Results: Subfoveal choroidal thickness was thinner with increasing severity of diabetic retinopathy. However, there was no significant difference between groups without the nasal side of the fovea. A statistically significant difference was observed over the fovea at the superotemporal area. Conclusions: The choroidal thickness outside of the fovea was thinner with the severity of diabetic retinopathy and was more pronounced in the superotemporal area.
참고문헌 (21)
- Antonetti DA., "Diabetic retinopathy : seeing beyond glucose-induced microvascular disease", Diabetes, 55, pp.2401~2411 (2006)
- Hidayat AA., "Diabetic choroidopathy. Light and electron microscopic observations of seven cases", Ophthalmology, 92, pp.512~522 (1985)
- Weinberger D., "Indocyanine green angiographic findings in nonproliferative diabetic retinopathy", Am J Ophthalmol, 126, pp.238~247 (1998)
- Shiragami C., "Risk factors for diabetic choroidopathy in patients with diabetic retinopathy", Graefes Arch Clin Exp Ophthalmol, 240, pp.436~442 (2002)
- Cao J., "Choriocapillaris degeneration and related pathologic changes in human diabetic eyes", Arch Ophthalmol, 116, pp.589~597 (1998)
- Coleman DJ., "High-resolution ultrasonic imaging of the posterior segment", Ophthalmology, 111, pp.1344~1351 (2004)
- Bartsch DU., "Confocal scanning infrared laser ophthalmoscopy for indocyanine green angiography", Am J Ophthalmol, 120, pp.642~651 (1995)
- Nagaoka T., "Alteration of choroidal circulation in the foveal region in patients with type 2 diabetes", Br J Ophthalmol, 88, pp.1060~1063 (2004)
- Spaide RF., "Enhanced depth imaging spectral-domain optical coherence tomography", Am J Ophthalmol, 146, pp.496~500 (2008)
- Margolis R., "A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes", Am J Ophthalmol, 147, pp.811~815 (2009)
- Fujiwara T., "Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes", Am J Ophthalmol, 148, pp.445~450 (2009)
- Imamura Y., "Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy", Retina, 29, pp.1469~1473 (2009)
- Spaide RF., "Age-related choroidal atrophy", Am J Ophthalmol, 147, pp.801~810 (2009)
- Manjunath V., "Choroidal thickness in normal eyes measured using Cirrus HD optical coherence tomography", Am J Ophthalmol, 150, pp.325~329.e1 (2010)
- Ikuno Y., "Choroidal thickness in healthy Japanese subjects", Invest Ophthalmol Vis Sci, 51, pp.2173~2176 (2010)
- Esmaeelpour M., "Mapping choroidal and retinal thickness variation in type 2 diabetes using three-dimensional 1060-nm optical coherence tomography", Invest Ophthalmol Vis Sci, 52, pp.5311~5316 (2011)
- Regatieri CV., "Choroidal thickness in patients with diabetic retinopathy analyzed by spectral-domain optical coherence tomography", Retina, 32, pp.563~568 (2012)
- Hee MR., "Topography of diabetic macular edema with optical coherence tomography", Ophthalmology, 105, pp.360~370 (1998)
- "Early Treatment Diabetic Retinopathy Study design and baseline patient characteristics. ETDRS report number 7", Ophthalmology, 98(5 Suppl), pp.741~756 (1991)
- Davis MD., "Vitreous contraction in proliferative diabetic retinopathy", Arch Ophthalmol, 74, pp.741~751 (1965)
- Taylor E., "Proliferative diabetic retinopathy. Site and size of initial lesions", Br J Ophthalmol, 54, pp.11~18 (1970)