스펙트럼영역과 시간영역 빛간섭단층촬영기로 측정한 망막신경섬유층 두께 비교
Comparison of Retinal Nerve Fiber Layer Thickness Measured by Spectral-Domain and Time-Domain Optical Coherence Tomography
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목적: 시간영역 빛간섭단층촬영기(stratus-optical coherence tomography)와 스펙트럼영역 빛간섭단층촬영기(3D-OCT)로 측정한 망막신경섬유층의 두께를 비교하였다. 대상과 방법: 정상 69안과 녹내장 92안을 대상으로 같은 날 Stratus-OCT의 fast RNFL scan과 3D-OCT의 optic disc cube scan으로유두주위 망막신경섬유층 두께를 구하였고, 두 측정치의 연관성을 알아보기 위해 상관분석과 Bland-Altman plot을 이용하였다. 결과: 전 대상에서 평균, 상사분면, 하사분면 망막신경섬유층 두께는 Stratus-OCT가 3D-OCT보다 두꺼웠고, 반면에 이측사분면, 비측사분면에서는 3D가 Stratus보다 두꺼웠다. 두 기기 간에 절대치는 차이가 있었으나 상관계수는 높았다(r=0.678-0.905). Bland-Altman plot에서 상대적으로 두꺼운 망막신경섬유층 두께에서는 Stratus-OCT가 3D-OCT보다 두껍게 측정되었고, 얇은 두께에서는 3D가Stratus보다 두껍게 측정되었다. 결론: 두 기기의 측정치를 비교할 때 망막신경섬유층 두께에 따라 차이가 있음을 고려하여야 한다.
Abstract
Purpose: To compare retinal nerve fiber layer (RNFL) thickness measured by time domain (Stratus) and spectral domain (3D) optical coherence tomography (OCT). Methods: Sixty-nine normal subjects and 92 glaucoma patients were included in the present study. Peripapillary RNFL thickness was measured with Stratus fast RNFL scan and 3D optic disc cube scan on the same day. The relationship between RNFL thickness measurements of the two OCTs were evaluated using a Pearson’s correlation analysis. A Bland-Altman plot was used for the comparison of Stratus-OCT and 3D-OCT. Results: In all subjects, average, superior, and inferior quadrant RNFL thicknesses measured by Stratus-OCT were thicker than those measured by 3D-OCT. In contrast, temporal and nasal quadrant RNFL thicknesses measured by 3D-OCT were thicker than those measured by Stratus-OCT. Although there were absolute value differences in RNFL thicknesses,high correlation was observed between Stratus-OCT and 3D-OCT (average: r = 0.897, temporal quadrant: r = 0.728, superior quadrant: r = 0.811, nasal quadrant: r = 0.678, and inferior quadrant: r = 0.905). Bland-Altman plots showed that Stratus-OCT values were greater than 3D-OCT values with relatively high RNFL thickness and the opposite with low RNFL thickness. Conclusions: For thicker RNFL, Stratus-OCT measurements tend to be greater than 3D-OCT, while for thinner RNFL,3D-OCT measurements tend to be greater than Stratus-OCT. This difference must be taken into account if comparing measurements made with a Stratus-OCT to the measurements of a 3D-OCT.
참고문헌 (22)
- Blumenthal EZ, "Reproducibility of nerve fiber layer thickness measurements by use of optical coherence tomography", Ophthalmology, 107, pp.2278~2282 (2000)
- Hood DC, "A comparison of retinal nerve fiber layer (RNFL) thickness obtained with frequency and time domain optical coherence tomography (OCT)", Opt Express, 17, pp.3997~4003 (2009)
- Inoue R, "Three-dimensional high-speed optical coherence tomography imaging of lamina cribrosa in glaucoma", Ophthalmology, 116, pp.214~222 (2009)
- Kotera Y, "Three-dimensional imaging of macular inner structures in glaucoma by using spectral-domain optical coherence tomography", Invest Ophthalmol Vis Sci, 52, pp.1412~1421 (2011)
- Menke MN, "Reproducibility of nerve fiber layer thickness measurements using 3D fourier-domain OCT", Invest Ophthalmol Vis Sci, 49, pp.5386~5391 (2008)
- Landis JR, "The measurement of observer agreement for categorical data", Biometrics, 33, pp.159~174 (1977)
- Vizzeri G, "Agreement between spectral domain and time-domain OCT for measuring RNFL thickness", Br J Ophthalmol, 93, pp.775~781 (2009)
- Sung KR, "Comparison of Retinal Nerve Fiber Layer Thickness Measured by Cirrus HD and Stratus Optical Coherence Tomography", OPHTHALMOLOGY, 116(7), pp.1264~1270, ELSEVIER SCIENCE INC
- Knight OJ, "Comparison of retinal nerve fiber layer measurements using time domain and spectral domain optical coherent tomography", Ophthalmology, 116, pp.1271~1277 (2009)
- Cho JW, "Detection of glaucoma by spectral domain scanning laser ophthalmoscopy", optical coherence tomography (SD-SLO, J Glaucoma, pp.2011, 20[DOI]
- Gonzalez-Garcıa AO, "Reproducibility of RTVue retinal nerve fiber layer thickness and optic disc measurements and agreement with Stratus optical coherence tomography measurements", Am J Ophthalmology, 147, pp.1067~1074 (2009)
- 김부기, "시간영역 빛간섭단층촬영기와 스펙트럼영역 빛간섭단층촬영기로 측정한 망막신경섬유층 두께 비교", 대한안과학회지, 50(10), pp.1539~1547 (2009), 대한안과학회
- Leung CKS, "Evaluation of scanning resolution on retinal nerve fiber layer measurement using optical coherence tomography in normal and glaucomatous eyes", J Glaucoma, 13, pp.479~485 (2004)
- Budenz DL, "Reproducibility of retinal nerve fiber thickness measurements using the Stratus OCT in normal and glaucomatous eyes", Invest Opthalmol Vis Sci, 46, pp.2440~2443 (2005)
- Legarreta JE, "Macular thickness measurements in normal eyes using spectral domain optical coherence tomography", Ophthalmic Surg Lasers Imaging, 39, pp.543~549 (2008)
- 송유미, "광간섭단층촬영기를 이용한 정상안과 초기 녹내장안의 구별", 대한안과학회지, 48(12), pp.1675~1685 (2007), 대한안과학회
- Ghadiali Q, "An analysis of normal variations in retinal nerve fiber layer thickness profiles measured with optical coherence tomography", J Glaucoma, 17, pp.333~340 (2008)
- Hood DC, "Blood vessel contributions to retinal nerve fiber layer thickness profiles measured with optical coherence tomography", J Glaucoma, 17, pp.519~528 (2008)
- Budenz DL, "Reproducibility of peripapillary retinal nerve fiber thickness measurements with Stratus OCT in glaucomatous eyes", Ophthalmology, 115, pp.661~666 (2008)
- Schuman JS, "Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography", Ophthalmology, 103, pp.1889~1898 (1996)
- Knighton RW, "An optical model of the human retinal nerve fiber layer: implications of directional reflectance for variability of clinical measurements", J Glaucoma, 9, pp.56~62 (2000)
- Vizzeri G, "Effect of improper scan alignment on retinal nerve fiber layer thickness measurements using Stratus optical coherence tomograph", J Glaucoma, 17, pp.341~349 (2008)