한국인의 건강검진에서 발견되는 대사증후군의 구성요소와 망막 혈관 변화와의 관계
Association between Metabolic Syndrome and Retinal Vascular Changes in Koreans based on Health Check-ups
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목적: 한국인의 건강검진에서 발견되는 대사증후군의 구성요소와 망막 혈관 변화와의 관계를 알아보고자 하였다. 대상과 방법: 381명을 대상으로 망막 출혈, 동정맥 함요, 망막 삼출물의 유무 및 IVAN 프로그램으로 측정한 망막 동맥 직경, 망막정맥 직경, 동정맥 비율과 대사증후군 및 각 인자들과의 관계를 분석하였다. 결과: 대사증후군, 복부비만, 중성지방은 망막 동맥 직경의 감소(p=0.032, 0.037, 0.011)와 유의한 관계가 있었으며, 중성지방은 동정맥 비율의 감소(p=0.005)와 유의한 관계가 있었다. 복부비만과 동정맥 함요(교차비 2.68, p=0.013), 복부비만과 망막 삼출물(교차비 2.30, p=0.038), 혈당과 망막출혈(교차비 8.06, p=0.030), 혈압과 동정맥 함요(교차비 2.78, p=0.007)는 유의한 관계를 보였다. 결론: 대사증후군은 망막 동맥 직경의 감소와 유의한 관계가 있으며, 대사증후군의 구성요소 중 복부비만은 망막 미세 혈관 변화와 가장 많은 연관성을 보인다.
Abstract
Purpose: To evaluate the associations between components of metabolic syndrome and retinal vascular changes in a Korean population based on data collected at health check-ups. Methods: Fundus photographs of 381 patients participating in a health check-up were examined to identify central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), and arteriovenous ratio (AVR) by IVAN software. Retinal hemorrhage, arteriovenous nicking, and retinal exudate were also noted. The association between metabolic syndrome and each component was then analyzed. Results: Significant associations were shown between metabolic syndrome and CRAE (p = 0.032), central obesity and CRAE (p = 0.037), triglyceride and CRAE (p = 0.011), and triglyceride and AVR (p = 0.005), in addition to central obesity and arteriovenous nicking (odds ratio [OR] = 2.68, p = 0.013), central obesity and retinal exudate (OR = 2.30, p = 0.038), serum glucose and retinal hemorrhage (OR = 8.06, p = 0.030), and blood pressure and arteriovenous nicking (OR = 2.78, p = 0.007). Conclusions: Metabolic syndrome showed a significant relationship with retinal artery diameter. Central obesity showed the greatest relationship with retinal vascular changes among each of the components of metabolic syndrome.
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