정상 한국인에서 연령에 따른 망막 혈관 직경과 관련 인자에 대한 분석
Analysis of Factors Associated with Retinal Vascular Caliber in Normal Korean Subjects
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
목적: 정상 한국인을 대상으로 망막 동정맥의 직경을 측정하고, 연령에 따른 망막 혈관 직경의 변화와 망막 혈관 직경에 영향을 미치는인자에 대하여 알아보고자 한다. 대상과 방법: 정상인 152명의 안저 사진을 촬영하고, 컴퓨터 프로그램(IVAN)을 이용하여 central retinal artery equivalent (CRAE)와 centralretinal vein equivalent (CRVE)를 측정하고, 연령, 성별, 고혈압, 당뇨, 흡연과 같은 관련 인자와 망막 혈관 직경과의 관계를 분석하였다. 결과: 정상 한국인의 망막 혈관 직경은 CRVE 209.33 ± 12.40 μm, CRAE 149.70 ± 9.01 μm로 측정되었고 연령이 증가함에 따라CRVE와 CRAE는 감소하였다(p＜0.001, respectively). CRVE와 CRAE는 남자가 여자보다 유의하게 크게 측정되었다(p=0.002,p=0.042, respectively). 연령과 성별을 통제한 후, 고혈압군의 CRVE와 CRAE는 비고혈압군에 비해 유의하게 작았으며(p=0.038,p=0.032, respectively), 흡연자군과 비흡연자군, 당뇨군과 비당뇨군에 대한 CRVE와 CRAE의 차이는 유의하지 않았다(p＞0.05,respectively). 결론: 정상 한국인의 망막 혈관 직경은 연령이 증가함에 따라 작아졌다. 성별과 고혈압은 망막 혈관 직경에 영향을 미치는 인자이며,흡연과 당뇨는 영향을 미치지 않았다.
Abstract
Purpose: To measure the diameter of the retinal arterial and venous caliber of normal Korean subjects and evaluate the factorsaffecting these diameters. Methods: Fundus photography was performed on 152 normal Korean subjects. Central retinal artery equivalent (CRAE) andcentral retinal vein equivalent (CRVE) were measured with a computer-based program (IVAN), and were used to investigate therelationship between the diameter and factors including age, gender, hypertension, diabetes, and smoking. Results: Among the study subjects, the CRVE was 209.33 ± 12.40 μm and the CRAE was 149.70 ± 9.01 μm. The CRVE andCRAE decreased with increasing age in all study subjects (both p < 0.001). There were significant gender differences in theCRVE and CRAE (p = 0.002, p = 0.042, respectively). After adjusting for age and gender, the hypertension group showed smallerCRVE and CRAE than the non-hypertension group (p = 0.038, p = 0.032, respectively). Smoking and diabetes were not significantfactors affecting the CRAE and CRVE (both p > 0.05). Conclusions: In our study group, retinal vascular caliber of normal Korean subjects decreased with aging. Retinal vascular caliberwas affected by gender and hypertension, but not by smoking and diabetes.
참고문헌 (30)
- Wong TY, "Quantitative retinal venular caliber and risk of cardiovascular disease in older persons: the cardiovascular health study", Arch Intern Med, 166, pp.2388~2394 (2006)
- Ikram MK, "Are retinal arteriolar or venular diameters associated with markers for cardiovascular disorders? The rotterdam study", Invest Ophthalmol Vis Sci, 45, pp.2129~2134 (2004)
- Wong TY, "Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA)", Invest Ophthalmol Vis Sci, 47, pp.2341~2350 (2006)
- McGeechan K, "Meta-analysis: retinal vessel caliber and risk for coronary heart disease", Ann Intern Med, 151, pp.404~413 (2009)
- Ikram MK, "Retinal vessel diameters and risk of stroke: the rotterdam study", Neurology, 66, pp.1339~1343 (2006)
- McGeechan K, "Prediction of incident stroke events based on retinal vessel caliber: a systematic review and individual-participant meta-analysis", Am J Epidemiol, 170, pp.1323~1332 (2009)
- Jeganathan VS, "Retinal vascular caliber and diabetes in a multiethnic asian population", Microcirculation, 16, pp.534~543 (2009)
- Islam FM, "Quantitative retinal vascular calibre changes in diabetes and retinopathy: the Singapore Malay eye study", Eye (Lond), 23, pp.1719~1724 (2009)
- Ikram MK, "Retinal vessel diameters and risk of impaired fasting glucose or diabetes: the rotterdam study", Diabetes, 55, pp.506~510 (2006)
- Wong TY, "Associations between the metabolic syndrome and retinal microvascular signs: the atherosclerosis risk in communities study", Invest Ophthalmol Vis Sci, 45, pp.2949~2954 (2004)
- Liew G, "Relative importance of systemic determinants of retinal arteriolar and venular caliber: The atherosclerosis risk in communities study", Arch Ophthalmol, 126, pp.1404~1410 (2008)
- Klein R, "Are inflammatory factors related to retinal vessel caliber? The beaver dam eye study", Arch Ophthalmol, 124, pp.87~94 (2006)
- Nguyen TT, "Relationship of retinal vascular caliber with diabetes and retinopathy: the multi-ethnic study of atherosclerosis (MESA)", Diabetes Care, 31, pp.544~549 (2008)
- Myers CE, "Determinants of retinal venular diameter: the beaver dam eye study", Ophthalmology, 119, pp.2563~2571 (2012)
- Zheng Y, "Relationship of retinal vascular caliber with retinal nerve fiber layer thickness: the Singapore Malay eye study", Invest Ophthalmol Vis Sci, 50, pp.4091~4096 (2009)
- Schoenborn CA, "Health behaviors of adults: United states, 2005-2007", Vital Health Stat 10, 245, pp.1~132 (2010)
- Scott WK, "Independent effects of complement factor H Y402H polymorphism and cigarette smoking on risk of age-related macular degeneration", Ophthalmology, 114, pp.1151~1156 (2007)
- "Grading diabetic retinopathy from stereoscopic color fundus photographs--an extension of the modified airlie house classification. ETDRS report number 10. Early treatment diabetic retinopathy study research group", Ophthalmology, 98, pp.786~806 (1991)
- Leung H, "Computer-assisted retinal vessel measurement in an older population: correlation between right and left eyes", Clin Experiment Ophthalmol, 31, pp.326~330 (2003)
- Hubbard LD, "Methods for evaluation of retinal microvascular abnormalities associated with hypertension", sclerosis in the atherosclerosis risk in communities study, 1999, pp.106, 2269~2280
- Knudtson MD, "Revised formulas for summarizing retinal vessel diameters", Curr Eye Res, 27, pp.143~149 (2003)
- Bewick V, "Statistics review 10: further nonparametric methods", Critical Care, 8, pp.196~199 (2004)
- McBane RD 2nd, "Comparison of plasminogen activator inhibitor-1, tissue type plasminogen activator antigen, fibrinogen, and D-dimer levels in various age decades in patients with type 2 diabetes mellitus and stable coronary artery disease (from the BARI 2D trial)", Am J Cardiol, 105, pp.17~24 (2010)
- Wong TY, "Retinal vessel diameters and their associations with age and blood pressure", Invest Ophthalmol Vis Sci, 44, pp.4644~4650 (2003)
- Leung H, "Relationships between age, blood pressure, and retinal vessel diameters in an older population", Invest Ophthalmol Vis Sci, 44, pp.2900~2904 (2003)
- Wong TY, "Estrogen replacement therapy and retinal vascular caliber", Ophthalmology, 112, pp.553~558 (2005)
- Wong TY, "Retinal arteriolar narrowing and risk of coronary heart disease in men and women. The atherosclerosis risk in communities study", JAMA, 287, pp.1153~1159 (2002)
- Wong TY, "Retinal microvascular abnormalities and blood pressure in older people: The cardiovascular health study", Br J Ophthalmol, 86, pp.1007~1013 (2002)
- Iida M, "Mechanisms underlying cerebrovascular effects of cigarette smoking in rats in vivo", Stroke, 29, pp.1656~1665 (1998)
- Sharrett AR, "Smoking, diabetes, and blood cholesterol differ in their associations with subclinical atherosclerosis:the multiethnic study of atherosclerosis (MESA)", Atherosclerosis, 186, pp.441~447 (2006)