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폐경기 여성에서 나이관련황반변성과 여성 호르몬 요인과의 관계: 제5기 국민건강영양조사 자료

Female Hormone Factors Associated with Age-related Macular Degeneration in Menopausal Korean Women: KNHANES V

이영훈|백승국
대한안과학회 (The Korean Ophthalmological Society)|2017.09|대한안과학회지 (Journal of The Korean Ophthalmological Society)|제58권 제9호|pp. 1066-1073

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Age-related macular degenerationKNHANES VFemale hormones
주제분류안과학

초록

목적: 폐경기 여성에서 나이관련황반변성과 여성 호르몬 요인과의 관계를 밝히고자 한다. 대상과 방법: 4,479명의 제5기 국민건강영양조사를 완료한 45세 이상의 폐경기 여성을 대상으로 나이관련황반변성 환자와 건강한 사람, 초기와 후기 나이관련황반변성 환자군을 구분하여 내인성 및 외인성 여성호르몬 인자와 나이관련황반변성의 관계에 대해 알아보았다. 결과: 전체 연구 대상자는 4,479명 중 나이관련황반변성군은 516명이었고, 정상군은 3,963명이었다. 두 군 간의 위험도 분석에서 나이를 제외한 다른 요인은 통계적 의미를 보이지 않았다. 전체 나이관련황반변성 516명 중 초기 나이관련황반변성군은 488명이었고, 후기 나이관련황반변성군은 28명이었으며, 피임약 사용기간이 길어질수록 후기 나이관련황반변성의 위험도가 초기 나이관련황반변성보다 1.013배 높았고(p=0.024, 95% confidence interval [CI]: 1.002-1.024), 출산력이 많을수록 후기 나이관련황반변성의 위험도가 초기 나이관련황반변성보다 0.672배로 낮았다(p=0.006, 95% CI: 0.506-0.893). 결론: 내인성 및 외인성 여성 호르몬 요인은 나이관련황반변성의 경과에 영향을 미칠 수 있다.

Abstract

Purpose: To investigate whether endogenous and exogenous female hormone exposures were associated with risks for age-related macular degeneration (AMD) in postmenopausal women. Methods: This study included 4,479 postmenopausal females aged 45 years and older who completed the Korea National Health and Nutrition Examination Survey (KNHANES) V. The participants were divided into 4 groups: subjects with AMD, subjects without AMD, subjects with early AMD, and subjects with late AMD. Variables associated with endogenous and exogenous female hormone exposures were analyzed. Results: Among the 4,479 participants, 516 were found to have AMD and 3,963 were normal. There was no significant difference between the AMD and normal groups execpt for age in the risk analysis. Of the total 516 AMD participants, 488 had early AMD and 28 had late AMD. Women with AMD who had used oral contraceptives longer in the past had significantly higher odds of late AMD than early AMD (odds ratio [OR] = 1.013, 95% confidence interval [CI]: 1.002-1.024). Increasing number of children was also associated with decreased odds of late AMD (OR = 0.672, 95% CI: 0.506-0.893). Conclusions: These findings suggest that exposure to endogenous and exogenous female hormones may influence the risk of AMD progression.

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