Retinal Nerve Fiber Layer Thickness Measurement Comparison Using Spectral Domain and Swept Source Optical Coherence Tomography
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Purpose: To investigate the retinal nerve fiber layer (RNFL) thickness concordance when measured by spectraldomain (SD) and swept source (SS) optical coherence tomography (OCT), and to compare glaucoma-discriminatingcapability. Methods: RNFL thicknesses were measured with the scan circle, centered on the optic nerve head, in 55healthy, 41 glaucoma suspected, and 87 glaucomatous eyes. The RNFL thickness measured by the SD-OCT(sdRNFL thickness) and SS-OCT (ssRNFL thickness) were compared using the t-test. Bland-Altman analysiswas performed to examine their agreement. We compared areas under the receiver operating characteristicscurve and examined sdRNFL and ssRNFL thickness for discriminating glaucomatous eyes from healthy eyes,and from glaucoma suspect eyes. Results: The average ssRNFL thickness was significantly greater than sdRNFL thickness in healthy (110.0 ± 7.9vs. 100.1 ± 6.8 μm, p < 0.001), glaucoma suspect (96.8 ± 9.3 vs. 89.6 ± 7.9 μm, p < 0.001), and glaucomatouseyes (74.3 ± 14.2 vs. 69.1 ± 12.4 μm, p = 0.011). Bland-Altman analysis showed that there was a tendencyfor the difference between ssRNFL and sdRNFL to increase in eyes with thicker RNFL. The area under thecurves of the average sdRNFL and ssRNFL thickness for discriminating glaucomatous eyes from healthy eyes(0.984 vs. 0.986, p = 0.491) and glaucoma suspect eyes (0.936 vs. 0.918, p = 0.132) were comparable. Conclusions: There was a tendency for ssRNFL thickness to increase, compared with sdRNFL thickness, ineyes with thicker RNFL. The ssRNFL thickness had comparable diagnostic capability compared with sdRNFLthickness for discriminating glaucomatous eyes from healthy eyes and glaucoma suspect eyes.
Abstract
Purpose: To investigate the retinal nerve fiber layer (RNFL) thickness concordance when measured by spectraldomain (SD) and swept source (SS) optical coherence tomography (OCT), and to compare glaucoma-discriminatingcapability. Methods: RNFL thicknesses were measured with the scan circle, centered on the optic nerve head, in 55healthy, 41 glaucoma suspected, and 87 glaucomatous eyes. The RNFL thickness measured by the SD-OCT(sdRNFL thickness) and SS-OCT (ssRNFL thickness) were compared using the t-test. Bland-Altman analysiswas performed to examine their agreement. We compared areas under the receiver operating characteristicscurve and examined sdRNFL and ssRNFL thickness for discriminating glaucomatous eyes from healthy eyes,and from glaucoma suspect eyes. Results: The average ssRNFL thickness was significantly greater than sdRNFL thickness in healthy (110.0 ± 7.9vs. 100.1 ± 6.8 μm, p < 0.001), glaucoma suspect (96.8 ± 9.3 vs. 89.6 ± 7.9 μm, p < 0.001), and glaucomatouseyes (74.3 ± 14.2 vs. 69.1 ± 12.4 μm, p = 0.011). Bland-Altman analysis showed that there was a tendencyfor the difference between ssRNFL and sdRNFL to increase in eyes with thicker RNFL. The area under thecurves of the average sdRNFL and ssRNFL thickness for discriminating glaucomatous eyes from healthy eyes(0.984 vs. 0.986, p = 0.491) and glaucoma suspect eyes (0.936 vs. 0.918, p = 0.132) were comparable. Conclusions: There was a tendency for ssRNFL thickness to increase, compared with sdRNFL thickness, ineyes with thicker RNFL. The ssRNFL thickness had comparable diagnostic capability compared with sdRNFLthickness for discriminating glaucomatous eyes from healthy eyes and glaucoma suspect eyes.
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