Use of Optical Coherence Tomography to Evaluate Visual Acuity and Visual Field Changes in Dengue Fever
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Dengue fever is a viral disease that is transmitted by mosquitoes and affects humans. In rare cases,dengue fever can cause visual impairment, which usually occurs within 1 month after contracting denguefever and ranges from mild blurring of vision to severe blindness. Visual impairment due to dengue fevercan be detected through angiography, retinography, optical coherence tomography (OCT) imaging,electroretinography, event electroencephalography (visually evoked potentials), and visual field analysis. The purpose of this study is to report changes in the eye captured using fluorescein angiography,indocyanine green, and OCT in 3 cases of dengue fever visual impairment associated with consistent visualsymptoms and similar retinochoroidopathic changes. The OCT results of the three patients with denguefever showed thinning of the outer retinal layer and disruption of the inner segment/outer segment (IS/OS)junction. While thinning of the retina outer layer is an irreversible process, disruption of IS/OS junction isreported to be reversible. Follow-up examination of individuals with dengue fever and associated visualimpairment should involve the use of OCT to evaluate visual acuity and visual field changes in patients withacute choroidal ischemia.
Abstract
Dengue fever is a viral disease that is transmitted by mosquitoes and affects humans. In rare cases,dengue fever can cause visual impairment, which usually occurs within 1 month after contracting denguefever and ranges from mild blurring of vision to severe blindness. Visual impairment due to dengue fevercan be detected through angiography, retinography, optical coherence tomography (OCT) imaging,electroretinography, event electroencephalography (visually evoked potentials), and visual field analysis. The purpose of this study is to report changes in the eye captured using fluorescein angiography,indocyanine green, and OCT in 3 cases of dengue fever visual impairment associated with consistent visualsymptoms and similar retinochoroidopathic changes. The OCT results of the three patients with denguefever showed thinning of the outer retinal layer and disruption of the inner segment/outer segment (IS/OS)junction. While thinning of the retina outer layer is an irreversible process, disruption of IS/OS junction isreported to be reversible. Follow-up examination of individuals with dengue fever and associated visualimpairment should involve the use of OCT to evaluate visual acuity and visual field changes in patients withacute choroidal ischemia.
참고문헌 (12)
- Gubler DJ, "The global emergence", resurgence of arboviral diseases as public health problems, 2002, pp.33, 330~342
- Richardson S, "Ocular symptoms and complications observed in dengue", Trans Am Ophthalmol Soc, 31, pp.450~477 (1933)
- Cruz-Villegas V, "Bilateral choroidal effusions associated with dengue fever", Retina, 23, pp.576~578 (2003)
- Wen KH, "The ocular fundus findings in dengue fever", Gaoxiong Yi Xue Ke Xue Za Zhi, 5, pp.24~30 (1989)
- Chia A, "Electrophysiological findings in patients with dengue-related maculopathy", Arch Ophthalmol, 124, pp.1421~1426 (2006)
- Morens DM, "Antibody-dependent enhancement of infection and the pathogenesis of viral disease", Clin Infect Dis, 19, pp.500~512 (1994)
- Su DH, "Prevalence of dengue maculopathy in patients hospitalized for dengue fever", Ophthalmology, 114, pp.1743~1747 (2007)
- Lim WK, "Ocular manifestations of dengue fever", Ophthalmology, 111, pp.2057~2064 (2004)
- Kurane I, "Immunopathologic mechanisms of dengue hemorrhagic fever and dengue shock syndrome", Arch Virol Suppl, 9, pp.59~64 (1994)
- Lei HY, "Immunopathogenesis of dengue virus infection", J Biomed Sci, 8, pp.377~388 (2001)
- Lin CF, "Antibodies from dengue patient sera cross-react with endothelial cells and induce damage", J Med Virol, 69, pp.82~90 (2003)
- Iida T, "Retinal and choroidal arterial occlusion in Wegener’s granulomatosis", Am J Ophthalmol, 133, pp.151~152 (2002)