Effect of Donor Age on Graft Survival in Primary Penetrating Keratoplasty with Imported Donor Corneas
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초록
Purpose: To investigate the influence of donor age on corneal graft survival following primary penetrating keratoplasty(PK) with imported donor corneas. Methods: The eyes of patients who underwent primary PK with imported donor corneas were classified retrospectivelyinto two groups according to a donor-age cutoff of 65 years. Primary outcome measures were rejection-free graft survival and graft survival. Cox proportional hazard regression analysis was used to assessthe factors affecting graft survival. Survival analysis was performed using the Kaplan-Meier method, whiledifferences between groups were examined using a log-rank test. A subgroup analysis of low- and high-riskeyes according to preoperative diagnosis was also performed. Results: A total of 140 eyes from 138 patients (age, 58 ± 18 years) were enrolled. Cox regression analysis revealedthat the donor age of 65 years or older group presented an increased risk of both graft rejection andfailure. Survival analysis revealed that rejection-free graft survival and graft survival rates were higher in eyesin the donor age of less than 65 years group. Finally, in the subgroup analysis, both rejection-free graft survivaland graft survival rates were significantly higher in the donor age of less than 65 years group than in the donorage of 65 years or older group, but only in the low-risk subgroup. Conclusions: Donor age may correlate with graft survival in primary PK performed with imported donor corneas. Donor age could be a considerable factor in primary PK with imported donor corneas, especially in preoperativelylow-risk patients.
Abstract
Purpose: To investigate the influence of donor age on corneal graft survival following primary penetrating keratoplasty(PK) with imported donor corneas. Methods: The eyes of patients who underwent primary PK with imported donor corneas were classified retrospectivelyinto two groups according to a donor-age cutoff of 65 years. Primary outcome measures were rejection-free graft survival and graft survival. Cox proportional hazard regression analysis was used to assessthe factors affecting graft survival. Survival analysis was performed using the Kaplan-Meier method, whiledifferences between groups were examined using a log-rank test. A subgroup analysis of low- and high-riskeyes according to preoperative diagnosis was also performed. Results: A total of 140 eyes from 138 patients (age, 58 ± 18 years) were enrolled. Cox regression analysis revealedthat the donor age of 65 years or older group presented an increased risk of both graft rejection andfailure. Survival analysis revealed that rejection-free graft survival and graft survival rates were higher in eyesin the donor age of less than 65 years group. Finally, in the subgroup analysis, both rejection-free graft survivaland graft survival rates were significantly higher in the donor age of less than 65 years group than in the donorage of 65 years or older group, but only in the low-risk subgroup. Conclusions: Donor age may correlate with graft survival in primary PK performed with imported donor corneas. Donor age could be a considerable factor in primary PK with imported donor corneas, especially in preoperativelylow-risk patients.
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