Clinical Outcomes of Nanothin Descemet Stripping Automated Endothelial Keratoplasty in Korean Patients with Corneal Endothelial Dysfunction
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Purpose: To evaluate the clinical outcomes of nanothin Descemet stripping automated endothelial keratoplasty (DSAEK) inKorean patients with corneal endothelial dysfunction. Methods: We retrospectively reviewed medical records of the patients who underwent nanothin DSAEK (graft thickness≤50 μm) due to corneal endothelial dysfunction and followed up more than 1 year. We evaluated best-corrected visual acuity(BCVA), central corneal thickness, and corneal endothelial cell density at preoperative and 1, 3, 6, and 12 months postoperatively. Results: Sixteen eyes of 16 patients with the mean follow-up period of 13.00 ± 0.96 months were included. The mean graftthickness after deswelling was 45.25 ± 4.59 μm (range, 38.0–50.0 μm). The mean logarithm of the minimum angle of resolutionBCVA improved from 1.37 ± 0.53 preoperatively to 0.68 ± 0.46, 0.55 ± 0.35, 0.40 ± 0.25, and 0.39 ± 0.25 at 1, 3, 6, and12 months postoperatively (p = 0.005, p < 0.001, p < 0.001, and p < 0.001), respectively. The mean central corneal thicknessimproved from 752.00 ± 129.11 to 555.75 ± 54.66 μm at 12 months postoperatively (p = 0.006). The mean graft endothelialcell density decreased from 2,859.62 ± 228.34 to 1,542.25 ± 627.34 cells/mm2 at 12 months postoperatively (p = 0.012). Thepostoperative complications included increased intraocular pressure (n = 3, 18.75%) and graft dislocation (n = 1, 6.25%), all ofwhich were successfully managed by anterior chamber paracentesis or rebubbling. No other serious complications were encountered. Conclusions: Nanothin DSAEK produced significant and stable visual improvements without severe postoperative complicationsin Korean patients with corneal endothelial dysfunction.
Abstract
Purpose: To evaluate the clinical outcomes of nanothin Descemet stripping automated endothelial keratoplasty (DSAEK) inKorean patients with corneal endothelial dysfunction. Methods: We retrospectively reviewed medical records of the patients who underwent nanothin DSAEK (graft thickness≤50 μm) due to corneal endothelial dysfunction and followed up more than 1 year. We evaluated best-corrected visual acuity(BCVA), central corneal thickness, and corneal endothelial cell density at preoperative and 1, 3, 6, and 12 months postoperatively. Results: Sixteen eyes of 16 patients with the mean follow-up period of 13.00 ± 0.96 months were included. The mean graftthickness after deswelling was 45.25 ± 4.59 μm (range, 38.0–50.0 μm). The mean logarithm of the minimum angle of resolutionBCVA improved from 1.37 ± 0.53 preoperatively to 0.68 ± 0.46, 0.55 ± 0.35, 0.40 ± 0.25, and 0.39 ± 0.25 at 1, 3, 6, and12 months postoperatively (p = 0.005, p < 0.001, p < 0.001, and p < 0.001), respectively. The mean central corneal thicknessimproved from 752.00 ± 129.11 to 555.75 ± 54.66 μm at 12 months postoperatively (p = 0.006). The mean graft endothelialcell density decreased from 2,859.62 ± 228.34 to 1,542.25 ± 627.34 cells/mm2 at 12 months postoperatively (p = 0.012). Thepostoperative complications included increased intraocular pressure (n = 3, 18.75%) and graft dislocation (n = 1, 6.25%), all ofwhich were successfully managed by anterior chamber paracentesis or rebubbling. No other serious complications were encountered. Conclusions: Nanothin DSAEK produced significant and stable visual improvements without severe postoperative complicationsin Korean patients with corneal endothelial dysfunction.
참고문헌 (18)
- Price FW Jr, "Evolution of endothelial keratoplasty", Cornea, 32(Suppl 1), pp.S28~S32 (2013)
- Schlogl A, "Long-term clinical outcome after descemet membrane endothelial keratoplasty", Am J Ophthalmol, 169, pp.218~226 (2016)
- Peraza-Nieves J, "Two-year clinical outcome of 500 consecutive cases undergoing descemet membrane endothelial keratoplasty", Cornea, 36, pp.655~660 (2017)
- Chamberlain W, "Descemet endothelial thickness comparison trial : a randomized trial comparing ultrathin descemet stripping automated endothelial keratoplasty with descemet membrane endothelial keratoplasty", Ophthalmology, 126, pp.19~26 (2019)
- Tourtas T, "Descemet membrane endothelial keratoplasty versus descemet stripping automated endothelial keratoplasty", Am J Ophthalmol, 153, pp.1082~1090 (2012)
- Durrani AF, "Ultrathin Descemet stripping automated endothelial keratoplasty", Curr Opin Ophthalmol, 30, pp.264~270 (2019)
- Trindade BLC, "Descemet membrane endothelial keratoplasty (DMEK): an update on safety, efficacy and patient selection", Clin Ophthalmol, 13, pp.1549~1557 (2019)
- Cheung AY, "Technique for preparing ultrathin and nanothin descemet stripping automated endothelial keratoplasty tissue", Cornea, 37, pp.661~666 (2018)
- Kurji KH, "Comparison of visual acuity outcomes between nanothin descemet stripping automated endothelial keratoplasty and descemet membrane endothelial keratoplasty", Cornea, 37, pp.1226~1231 (2018)
- Tourabaly M, "Influence of graft thickness and regularity on vision recovery after endothelial keratoplasty", Br J Ophthalmol, 104, pp.1317~1323 (2020)
- Stuart AJ, "Descemet’s membrane endothelial keratoplasty(DMEK)versus Descemet’s stripping automated endothelial keratoplasty(DSAEK)for corneal endothelial failure", Cochrane Database Syst Rev, 6, pp.CD012097~ (2018)
- Terry MA, "Endothelial cell loss after Descemet’s stripping endothelial keratoplasty in a large prospective series", Ophthalmology, 115, pp.488~496.e3 (2008)
- Terry MA, "Endothelial keratoplasty for Fuchs’ dystrophy with cataract : complications and clinical results with the new triple procedure", Ophthalmology, 116, pp.631~639 (2009)
- Hjortdal J, "Descemet’s stripping automated endothelial keratoplasty and penetrating keratoplasty for Fuchs’endothelial dystrophy", Acta Ophthalmol, 87, pp.310~314 (2009)
- Suh LH, "Complications of Descemet’s stripping with automated endothelial keratoplasty : survey of 118 eyes at One Institute", Ophthalmology, 115, pp.1517~1524 (2008)
- Deng SX, "Descemet Membrane endothelial keratoplasty : safety and outcomes : a report by the American Academy of Ophthalmology", Ophthalmology, 125, pp.295~310 (2018)
- Busin M, "Ultrathin Descemet’s stripping automated endothelial keratoplasty with the microkeratome double-pass technique : two-year outcomes", Ophthalmology, 120, pp.1186~1194 (2013)
- "Performing DSAEK: a step-by-step guide" (2014)[URL]