자기공명영상을 이용한 건강한 한국인 청년 조가비핵과 꼬리핵의 부피
The Putamen and Caudate Nucleus Volume in Korean Youth by MRI Volumetry
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
줄무늬체는 꼬리핵과 조가비핵으로 구성된 바닥핵으로 운동기능 조절에 관여하는 것으로 알려져 있다. 줄무늬체의 이상과 관련된 질환으로 헌팅톤 무도병, 뚜렛 증후군, 강박장애 및 정신분열증이 보고되고 있으나, 건강한 정상인에 초점을 맞춘 줄무늬체 부피에 관한 보고는 아직까지 찾을 수 없어, 이 연구에서 건강한 20대 한국인 청년을대상으로 줄무늬체 부피를 측정하였다. 남자 28명, 여자 29명의 자원자를 대상으로 간단한 문진과 신경학적 검사를거친 후, 뇌의 자기공명영상을 얻었다. 얻어진 자료는 DICOM형식으로 저장한 후 V-Works Program으로 불러내어머리뼈안 부피, 꼬리핵 부피, 조가비핵 부피를 모델링하고 측정하였다. 꼬리핵의 경우 남자는 7.23±1.18 cm3, 여자는6.23±0.96 cm3였고, 조가비핵의 경우 남자는 7.19±1.25 cm3, 여자는 6.38±0.86 cm3로 전체 머리뼈안 부피로 보정한각각의 뇌부피는 남녀 간의 차이를 보이지 않았다. 하지만 오른쪽 꼬리핵이 남녀 모두에서 왼쪽보다 오른쪽이 크게관찰되었으며, 조가비핵은 양쪽의 크기 차이가 없었다. 이 연구결과는 향후 줄무늬체와 관련 뇌기능과 질환연구의 중요한 기초자료로 활용될 것이다.
Abstract
Corpus striatum is subcortical nuclei composed of caudate nucleus and putamen. It has been considered to be associated with motor control and learning. Dysfunction of the striatum is related to Huntington’s disease, Tourette’s syndrome, obsessive-compulsive disorder and schizophrenia. Nevertheless, standard Korean striatum volume was not set yet. Here, we report the striatum volume in healthy Korean youths. The subjects were composed of 57 youths (male, 28; female, 29). The MRI study was undertaken after a brief history taking and neurological examination. The DICOM files were imported into V-Works program. Volume models of the intracranial cavity, whole brain, caudate nucleus, and putamen were made and their volumes were calculated by the program. The average caudate volume was 7.23±1.18 cm3 in male group and 6.23±0.96 cm3 in female group. The average volume of putamen was 7.19±1.25 cm3 in male group and 6.38±0.86 cm3 in female group. Interestingly the right caudate volume is significantly larger in both group, although there is no difference in putamen volume. This study reports Korean corpus striatum volume in healthy volunteers. These results would provide an important standard reference for further study.
참고문헌 (43)
- Dupuis JH, "Aging of the cerebellar hemispheres and vermis observed in IN VIVO", Soc Neurosci. Abstr, 21, pp.1536~ (1995)
- DeLisi LE, "Schizophrenia as a chronic active brain process:a study of progressive brain structural change subsequent to the onset of schizophrenia", Psychiatry Res, 74, pp.129~140 (1997)
- Matsumae M, "Age-related changes in intracranial compartment volumes in normal adults assessed by magnetic resonance imaging", J Neurosurg, 84, pp.982~991 (1996)
- Lenroot RK, "Brain development in children and adolescents: Insights from anatomical magnetic resonance imaging", Neurosci and Biobehav Rev, 30, pp.718~729 (2006)
- Holttum JR, "Magnetic resonance imaging of the posterior fossa in autism", Biol Psychiatry, 32, pp.1091~1101 (1992)
- Piven J, "An MRI study of autism:the cerebellum revisited", Neurology, 49, pp.546~551 (1997)
- van Eijndhoven P, "Amygdala volume marks the acute state in the early course of depression", Biol Psychiatry, 65, pp.812~818 (2009)
- Sun J, "Superior temporal gyrus volume change in schizophrenia: a review on region of interest volumetric studies", Brain Res Rev, 61, pp.14~32 (2009)
- Reiss AL, "Brain development, gender and IQ in children-a volumetric imaging study", Brain, 119, pp.1763~1774 (1996)
- Coffey CE, "Sex differences in brain aging: a quantitative magnetic resonance imaging study", Arch Neurol, 55, pp.169~179 (1998)
- Nagai F, "Investigation of Korean brain sulcus", Seoul Medical Education Institution Bulletin, 3, pp.15~29 (1933)
- Shibata I, "Brain weight of the Korean", Am J Phys Anthropol, 22, pp.27~35 (1936)
- Lee Y, "A Statistical Study on the weight of the brain Korean", Chosun Medical Report, 1, pp.1~71 (1947)
- Wee DY, "Morphological Study on the Korean infants’ brain sulcus", J Cathlic Med College, 4, pp.49~106 (1960)
- Lee MB, "Statistics on the Korean brain weight", The New Medical Journal, 6, pp.771~775 (1963)
- Kang-EHong, "The Segmented Regional Volumes of the Cerebrum and Cerebellum in Boys with Tourette Syndrome", Journal of Korean Medical Science, 17(4), pp.530~536 (2002), 대한의학회
- Choi JS, "Left anterior subregion of orbitofrontal cortex volume reduction and impaired organizational strategies in obsessivecompulsive disorder", J Psychiatr Res, 38, pp.193~199 (2004)
- Rhyu IJ, "Study of the Normal Cerebellar Volume Estimated by Magnetic Resonance Imaging (MRI) in Korean", Kor J Anat, 30, pp.575~579 (1997)
- Koh I, "Body size effect on brain volume in Korean youth", Neuroreport, 16, pp.2029~2032 (2005)
- Rhyu IJ, "Magnetic resonance image-based cerebellar volumetry in healthy Korean adults", Neurosci Lett, 270, pp.149~152 (1999)
- Chung SC, "Effects of gender, age, and body parameters on the ventricular volume of Korean people", Neurosci Lett, 395, pp.155~158 (2006)
- Lee BY, "A volumetric study of the corpus callosum in 20s and 40s Korean people", Brain Struct Funct, 213, pp.463~467 (2009)
- Lee MS, "Korean standard brain volume based on 3 dimensional MRI volumetry", Doctor, pp.2004
- Anatasi G, "In vivo basal ganglia volumetry through application of NURBS models to MR images", Neuroradiology, 48, pp.338~345 (2006)
- Jang JH, "A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder", Am J Psychiatry, 163, pp.1202~1207 (2006)
- Harris GJ, "Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington’s disease", Annals of Neurology, 31, pp.69~75 (1992)
- Aylward EH, "Reduced basal ganglia volume associated with the gene for Huntington’s disease in asymptomatic at-risk persons", Neurology, 44, pp.823~828 (1994)
- Hyde TM, "Cerebral morphometric abnormalities in Tourette’s syndrome A quantitative MRI study of monozygotic twins", Neurology, 45, pp.1176~1182 (1995)
- Filipek PA, "The young adult human brain: an MRI-based morphometric analysis", Cereb Cortex, 4, pp.344~360 (1994)
- Ostby Y, "Heterogeneity in subcortical brain development:A structural magnetic resonance imaging study of brain maturation from 8 to 30 years", J Neurosci, 29, pp.11772~11782 (2009)
- Yamashita K, "Volumetric Asymmetry and Differential Aging Effect of the Human Caudate Nucleus in Normal Individuals: A Prospective MR Imaging Study", J Neuroimaging, 21, pp.34~37 (2011)
- Goldstein JM, "Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging", Cereb Cortex, 11, pp.490~497 (2001)
- Hynd GW, "Attention deficit-hyperactivity disorder and asymmetry of the caudate nucleus", J Child Neurol, 8, pp.339~347 (1993)
- Mataró M, "Magnetic resonance imaging measurement of the caudate nucleus in adolescents with attention-deficit hyperactivity disorder and its relationship with neuropsychological and behavioral measures", Arch Neurol, 54, pp.963~968 (1997)
- Gunning-Dixon FM, "Differential aging of the human striatum: a prospective MR imaging study", AJNR, 19, pp.1501~1507 (1998)
- Peterson B, "Reduced basal ganglia volumes in Tourette’s syndrome using three-dimensional reconstruction techniques from magnetic resonance images", Neurology, 43, pp.941~949 (1993)
- Castellanos FX, "Quantitative morphology of the caudate nucleus in attention deficit hyperactivity disorder", Am J Psychiatry, 151, pp.1791~1796 (1994)
- Castellanos FX, "Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder", Arch Gen Psychiatry, 53, pp.607~616 (1996)
- Castelo JM, "Putamen hypertrophy in nondemented patients with human immunodeficiency virus infection and cognitive compromise", Arch Neurol, 64, pp.1275~1280 (2007)
- Ifthikharuddin SF, "MR volumetric analysis of the human basal ganglia: normative data", Acad Radiol, 7, pp.627~634 (2000)
- Giedd JN, "Quantitative magnetic resonance imaging of human brain development: ages 4-18", Cereb Cortex, 6, pp.551~560 (1996)
- Giedd JN, "Structural magnetic resonance imaging of the adolescent brain", Ann N Y Acad Sci, 1021, pp.77~85 (2004)
- Savic I, "Asymmetry of cerebral gray and white matter and structural volumes in relation to sex hormones and chromosomes", Frontiers in Neuroscience, 8, pp.329~ (2014)