조현병 및 비이환 형제에서 피질하 구조물의 변형
Subcortical Deformities in Schizophrenic Patients and Unaffected Siblings
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참고문헌
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초록
조현병, 비이환 형제 및 정상군의 자기공명영상을 이용하여피질하 구조물들의 부피와 모양을 비교한 결과, 왼쪽 담창구구조적 이상 및 왼쪽 담창구와 왼쪽 피각의 부피감소가 조현병의 유전적 소인을, 왼쪽 미상핵의 부피 감소가 질병 발현의소임임을 시사한다.
Abstract
Objectives Abnormalities in various subcortical regions have been reported in previous structural neuroimaging studies for schizophrenia. To understand the subcortical abnormalities as a whole, all subcortical regions should be explored in each subject unlike most previous studies. Here, we explored major subcortical structures using volume measurement and shape analysis for schizophrenic patients (SZ), their unaffected siblings (Sib) and healthy controls without affected sibling (HC). Methods Structural magnetic resonance images were acquired from 24 SZ, 24 Sib and 19 HC. Both segmentation and shape analysis for subcortical structures was performed using FMRIB Integrated Registration and Segmentation Tool integrated within the FSL software. The group comparison of subcortical volumes was performed with multivariate analysis of variance (MANOVA). Results In SZ group, shape deformities were observed in the left nucleus caudates, left thalamus, left putamen and bilateral pallidus were increased compared with HC group. In Sib group, shape deformities were observed in the left pallidus, left putamen and left putamen was decreased compared with HC group. In Sib group, left nucleus accumbens was increased compared with SZ group. Conclusion The result of this study using volume measurement and shape analysis suggest that subcortical structural abnormalities in cortico-striato-pallido-thalamic and reward circuits are related with both the pathology of schizophrenia and genetic predisposition.
참고문헌 (33)
- Ingvar DH, "Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia", Acta Psychiatr Scand, 50, pp.425~462 (1974)
- Wright IC, "Meta-analysis of regional brain volumes in schizophrenia", Am J Psychiatry, 157, pp.16~25 (2000)
- Honea R, "Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies", Am J Psychiatry, 162, pp.2233~2245 (2005)
- Witthaus H, "Hippocampal subdivision and amygdalar volumes in patients in an at-risk mental state for schizophrenia", J Psychiatry Neurosci, 35, pp.33~40 (2010)
- Harms MP, "Thalamic shape abnormalities in individuals with schizophrenia and their nonpsychotic siblings", J Neurosci, 27, pp.13835~13842 (2007)
- Konick LC, "Meta-analysis of thalamic size in schizophrenia", Biol Psychiatry, 49, pp.28~38 (2001)
- Staal WG, "Partial volume decrease of the thalamus in relatives of patients with schizophrenia", Am J Psychiatry, 155, pp.1784~1786 (1998)
- Andreasen NC, "The role of the thalamus in schizophrenia", Can J Psychiatry, 42, pp.27~33 (1997)
- Weinberger DR, "On localizing schizophrenic neuropathology", Schizophr Bull, 23, pp.537~540 (1997)
- Portas CM, "Volumetric evaluation of the thalamus in schizophrenic male patients using magnetic resonance imaging", Biol Psychiatry, 43, pp.649~659 (1998)
- Lipska BK, "Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: a potential animal model of schizophrenia", Neuropsychopharmacology, 9, pp.67~75 (1993)
- Wright IC, "Mapping of grey matter changes in schizophrenia", Schizophr Res, 35, pp.1~14 (1999)
- Wolkin A, "Structural magnetic resonance image averaging in schizophrenia", Am J Psychiatry, 155, pp.1064~1073 (1998)
- Bouix S, "Hippocampal shape analysis using medial surfaces", Neuroimage, 25, pp.1077~1089 (2005)
- Mamah D, "Basal ganglia shape abnormalities in the unaffected siblings of schizophrenia patients", Biol Psychiatry, 64, pp.111~120 (2008)
- Correa M, "Nucleus accumbens dopamine and work requirements on interval schedules", Behav Brain Res, 137, pp.179~187 (2002)
- Grace AA, "Gating of information flow within the limbic system and the pathophysiology of schizophrenia", Brain Res Brain Res Rev, 31, pp.330~341 (2000)
- Early TS, "Hyperactivity of the left striato-pallidal projection. Part I: Lower level theory", Psychiatr Dev, 7, pp.85~108 (1989)
- Hokama H, "Caudate, putamen, and globus pallidus volume in schizophrenia:a quantitative MRI study", Psychiatry Res, 61, pp.209~229 (1995)
- Heckers S, "Neuropathology of schizophrenia: cortex, thalamus, basal ganglia, and neurotransmitter-specific projection systems", Schizophr Bull, 23, pp.403~421 (1997)
- Chakos MH, "Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs", Am J Psychiatry, 151, pp.1430~1436 (1994)
- Lawrie SM, "Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies", Br J Psychiatry, 172, pp.110~120 (1998)
- Velakoulis D, "Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia,first-episode psychosis, and ultra-high-risk individuals", Arch Gen Psychiatry, 63, pp.139~149 (2006)
- Hwang J, "Basal ganglia shape alterations in bipolar disorder", Am J Psychiatry, 163, pp.276~285 (2006)
- Byne W, "Magnetic resonance imaging of the thalamic mediodorsal nucleus and pulvinar in schizophrenia and schizotypal personality disorder", Arch Gen Psychiatry, 58, pp.133~140 (2001)
- 김대식, "Diffusion tensor fiber tracking shows distinct Corticostriatal circuits in humans", ANNALS OF NEUROLOGY, 55(4), pp.522~529, WILEY-LISS
- Kandel ER, "Principles of neural science" (2000), McGraw-Hill
- Yazici AH, "Neurological soft signs in schizophrenic patients and their nonpsychotic siblings", Schizophr Res, 58, pp.241~246 (2002)
- Krauzlis RJ, "Recasting the smooth pursuit eye movement system", J Neurophysiol, 91, pp.591~603 (2004)
- Abel LA, "Abnormalities of smooth pursuit and saccadic control in schizophrenia and affective disorders", Vision Res, 32, pp.1009~1014 (1992)
- Boos HB, "Brain volumes in relatives of patients with schizophrenia: a meta-analysis", Arch Gen Psychiatry, 64, pp.297~304 (2007)
- Scherk H, "Effects of antipsychotics on brain structure", Curr Opin Psychiatry, 19, pp.145~150 (2006)
- Margolese HC, "Drug and alcohol use among patients with schizophrenia and related psychoses:levels and consequences", Schizophr Res, 67, pp.157~166 (2004)