Tourette 장애 소년에서 자기공명영상을 이용한 기저핵의 용적 분석
The Volumetric MRI Analysis of the Basal Ganglia in Boys with Tourette’s Disorder
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives：The purpose of this study was to investigate the regional differences of the basal ganglia volume between the boy subjects who have Tourette’s disorder and the control group who don’t have this disorder by using Brain MRI. Methods：Sixteen subjects who were diagnosed as Tourette’s disorder using DSM-IV criteria, and sixteen healthy subjects were selected. For analysis the coronal slice images of the basal ganglia were collected and collected MR images were analyzed with NIH Image (version 6.1 ppc). Results：The total brain volume in the subjects with Tourette’s disorder were smaller than control group by 6.2% (F=6.2, d.f.=1, p=0.019). The right putamen volume in boys with Tourette’s disorder were significant smaller than control group statistically (F=3.2, d.f.=3, p=0.040). The asymmetry (left>right) in the globus pallidus decreased significantly in the boys with Tourette’s disorder (p=0.06) were found from this experiment. Conclusion：These findings suggest that boys with Tourette’s disorder may have neuropathological abnormalities in the basal ganglia. Moreover, the present findings point out the important role of basal ganglia, especially putamen, in pathophysiology of Tourette’s disorder. More studies about the structural and functional analysis of the basal ganglia in Tourette’s disorder are highly required. (J Korean Neuropsychiatr Assoc 2008;47(4):311-317)
Abstract
Objectives：The purpose of this study was to investigate the regional differences of the basal ganglia volume between the boy subjects who have Tourette’s disorder and the control group who don’t have this disorder by using Brain MRI. Methods：Sixteen subjects who were diagnosed as Tourette’s disorder using DSM-IV criteria, and sixteen healthy subjects were selected. For analysis the coronal slice images of the basal ganglia were collected and collected MR images were analyzed with NIH Image (version 6.1 ppc). Results：The total brain volume in the subjects with Tourette’s disorder were smaller than control group by 6.2% (F=6.2, d.f.=1, p=0.019). The right putamen volume in boys with Tourette’s disorder were significant smaller than control group statistically (F=3.2, d.f.=3, p=0.040). The asymmetry (left>right) in the globus pallidus decreased significantly in the boys with Tourette’s disorder (p=0.06) were found from this experiment. Conclusion：These findings suggest that boys with Tourette’s disorder may have neuropathological abnormalities in the basal ganglia. Moreover, the present findings point out the important role of basal ganglia, especially putamen, in pathophysiology of Tourette’s disorder. More studies about the structural and functional analysis of the basal ganglia in Tourette’s disorder are highly required. (J Korean Neuropsychiatr Assoc 2008;47(4):311-317)
참고문헌 (27)
- Popper C, "Disorders usually first diagnosed in infancy, childhood, or adolescence ; Textbook of psychiatry", pp.825~954 (1999), American psychiatry press
- Teicher MH, "Neuropsychiatric disorders of childhood and adolescence ; Textbook of neuropsychiatry", pp.903~940 (1997), Washington DC: American psychiatry press
- Peterson B, "Reduced basal ganglia volumes in Tourette’s syndrome using three-dimensional reconstruction techniques from magnetic resonance images", Neurology, 43, pp.941~949 (1993)
- Singer HS, "Volumetric MRI changes in basal ganglia of children with Tourette’s syndrome", Neurology, 43, pp.950~956 (1993)
- Hyde TM, "Cerebral morphometric abnormalities in Tourette’s syndrome: a quantitative MRI study of monozygotic twins", Neurology, 45, pp.1176~1182 (1995)
- Moriarty J, "A volumetric MRI study of Gilles de la Tourette’s syndrome", Neurology, 49, pp.410~415 (1997)
- Peterson BS, "Basal Ganglia volumes in patients with Gilles de la Tourette syndrome", Arch Gen Psychiatry, 60, pp.415~424 (2003)
- Hong KE, "The segmented regional volumes of the cerebrum and cerebellum in boys with Tourette syndrome", J Korean Med Sci, 17, pp.530~536 (2002)
- American Psychiatric Association, "Diagnostic and Statistical Manual Disorders, 4th ed" (1994), American Psychiatric Association
- Denckla MB, "Revised Neurologic Examination for Subtle Signs (1985)", Psychopharmacol Bull, 21, pp.773~800 (1985)
- Chung SJ, "Development of the Korean Form of Yale Global Tic Severity Scale: a validity and reliability study", J Korean Neuropsychiatr Assoc, 37, pp.942~951 (1998)
- Park KS, "KEDI-WISC (Korean Educational Development Institute-Wechsler Intelligence Scale for Children)", ~ (1987)
- Oh KJ, "K-CBCL (Korean-child Behaviar checklist)" (1997), 중앙적성출판사
- Oh KJ, "Assessment of ADHD with abbreviated Conners rating scale", Korean J Clin Psychology, 8, pp.135~142 (1989)
- Lee JS, "Development of the Korean form of Leyton obsessional inventory-child version (LOI-CV)", Korean J Child & Adol Psychiatr, 5, pp.162~171 (1994)
- Reiss A, "Brainimage" (1999), Stanford University
- Subramaniam B, "Software and methods for quantitative imaging in neuroscience: the Kennedy Krieger Institute human brain project ; Neuroinformatics: an overview of the human brain project", pp.335~360 (1997), Lawrence Erlbaum Associates
- Kates WR, "Automated Talairach atlas-based parcellation and measurment of cerebral lobes in children", Psychiatry Res, 91, pp.11~30 (1999)
- Andreasen NC, "Automatic atlas-based volume estimation of human brain regions from MR images", J Comp Assist Tomogr, 20, pp.98~106 (1996)
- Talairach J, "Co-planar stereotaxic atlas of the human brain", Thieme medical, ~ (1998)
- Alexander GE, "Parallel organization of functionally segregated circuits linking basal ganglia and cortex", Annu Rev Neurosci, 9, pp.357~381 (1986)
- Cummings JL, "Frontal-subcortical circuits and human behavior", Arch Neurol, 50, pp.873~880 (1993)
- Singer HS, "Neurobiology of Tourette’s syndrome: concepts of neuroanatomic localization and neurochemical abnormalities", Brain Dev, 25(1), pp.70~84 (2003)
- Richardson EP, "Neuropathological studies of Tourette’s syndrome", pp.83~87 (1982), Raven Press
- Braun AR, "The functional neuroanatomy of Tourette’s syndrome: an FDGPET study. I. Regional changes in cerebral glucose metabolism differentiating patients and controls", Neuropsychopharmacology, 9, pp.277~291 (1993)
- Chase TN, "Structural and functional studies of Gilles de la Tourette syndrome", Rev Neurol (Paris), 142, pp.851~855 (1986)
- Castellanos FX, "Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder", Arch Gen Psychiatry, 53, pp.607~616 (1996)