본문 바로가기
KERD
논문KCI 등재

BALB/c 생쥐에서 천식 발생에 대한 dehydroepiandrosterone의 억제효과

Suppressive effect of dehydroepiandrosterone on the development of asthmatic readtion in BALB/c mice

고영아|이현철|최인선|고영일|최용
대한천식알레르기학회 (The Korean Academy of Asthma, Allergy and Clinical Immunology)|2004.03|천식 및 알레르기|제24권 제1호|pp. 116-126

1

조회

0

다운로드

2

인용

0

참고문헌

주제분류임상병리학

초록

Abstract

Background：Dehydroepiandrosterone (DHEA), an adrenal androgen, may regulate Th1/Th2 cytokines. Objective：To determine whether DHEA have a preventive effect against the development of asthma, a Th2-associated disease. Materials and methods：Female BALB/c mice were fed with a standard diet incorporated with 0.1% (w/w) of DHEA for 1 week before sensitization with ovalbumin (OVA, 20 &micro;g i.p. twice with 2-week intervals). Enhanced pause (Penh) was monitored after 1% OVA inhalations for 3 successive days, and then the methacholine bronchoprovocation tests were performed using a whole-body plethysmography system. Analyses of inflammatory cells, cytokines, and OVA-specific IgE were carried out. Results：Both the excessive airway narrowing (maximum Penh) and the airway hypersensitivity (PC200, mg/mL) to methacholine were significantly suppressed with the DHEA pretreatment (P<.05 and P<.01, respectively). However, the numbers of the inflammatory cells and the levels of interleukin (IL)-4, IL-5, and interferon (IFN)-γ in the bronchoalveolar lavage fluid, the production of IL-4, IL-5, and IFN-γ by Con A-stimulated splenocytes, and the serum IgE level in DHEA group were not significantly different from those in asthma group. Conclusion：DHEA pretreatment could suppress the development of asthmatic airway hyperresponsiveness without suppression of Th2 cytokines and airway inflammation. (J Asthma Allergy Clin Immunol 24: 116-26, 2004)

참고문헌 (28)

  1. "Global initiative for asthma. Global strategy for asthma management and prevention.", (02) (2002), NIH Publication
  2. "Are you Th-1 or Th-2?", 25, pp.389~390 (1995)
  3. "The importance of Th2-like cells in the pathogenesis of airway allergic inflammation", 23, pp.360~9 (1993)
  4. "Th1 and Th2 CD4+ cells in human allergic disease", 100, pp.1~6 (1997)
  5. "Development and inhibition of Th2 responses. Realization of therapeutic targets. In Agosti JM, Sheffer AL(eds.) Biotherapeutic approaches to asthma.", pp.247~291 (2002), Marcel Dekker, Inc.
  6. "Disorders of the adrenal cortex. In Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL(eds.) Harrison's Principles of internal medicine.", pp.2084~2105 (2001), McGraw-Hill
  7. "Introduction. DHEA: A coming of age." (1995)
  8. "Regulation of murine lymphokine production in vivo Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cells", pp.793~802
  9. "Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women", 169, pp.1536~9 (1993)
  10. "Cytokine dysregulation and increased oxidation is prevented by dehydroepiandrosterone in mice infected with murine leukemia retrovirus", 216, pp.386~391 (1997)
  11. "Exogenous dehydroepiandrosterone modified the expression of T helper-related cytokines in NZB", NZW F1 mice, 1998, pp.27, 291~302
  12. "Dehydroepiandrosterone sulphate concentrations in asthmatic patients:pilot study", 97, pp.805~8 (1984)
  13. "Adrenal function in acute asthma", 98, pp.843~6 (1985)
  14. "Attenuation of house dust mite Dermatophagoides farinae-induced airway allergic responses in mice by dehydroepiandrosterone is correlated with down-regulation of Th2 response", 29, pp.414~422 (1999)
  15. "Dehydroepiandrosterone attenuates allergic airway inflammation in Dermatophagoides farinae-sensitized mice", 35, pp.199~202 (2002)
  16. "Bronchoalveolar cell profiles of asthmatic and nonasthmatic subjects", 136, pp.379~83 (1987)
  17. "Effect of an anti-Mo1 MAb on ozone- induced airway inflammation and airway hyperresponsiveness in dogs", 263, pp.~6 (1992)
  18. "Effect of therapy on bronchial hyperresponsiveness in the long-term management of asthma", 18, pp.165~76 (1988)
  19. "Dehydroepiandrosterone antagonizes the suppressive effects of dexamethasone on lymphocytes proliferation", 129, pp.3174~9 (1991)
  20. "DHEA pretreatment protects rats against the preoxidant and necrogenic effects of carbon tetrachloride", 46, pp.1689~94 (1993)
  21. "Dehydorepiandrosterone attenuates the spontaneous elevation of serum IgE level in NC", Nga mice, 2001, pp.79, 177~179
  22. "Listeria monocytogenes 감염에 대한 마우스의 저항성에 미치는 Dehydroepiandrosterone의 영향", 14, pp.273~85 (1992)
  23. "Therapeutic effects of BCG vaccination in adult asthmatic patients: a randomized, controlled trial", 88, pp.584~591 (2002)
  24. "Dehydroepiandrosterone and analogs inhibit DNA binding of AP-1 and airway smooth muscle proliferation", 285, pp.876~883 (1998)
  25. "Airway remodeling in asthma", 123(3), pp.417S~22S (2003)
  26. "Peripheral blood CD4+ and CD8+ T cell type 1 and type 2 cytokine production in atopic asthmatic and normal subjects", 32, pp.427~433 (2002)
  27. "Development of airway hyperresponsiveness is dependent on interferon- and independent of eosinophil infiltration", 16, pp.325~34 (1977)
  28. "Immunologic changes associated with allergen immunotherapy", 102, pp.157~164 (1998)

관련 논문AI추천

동물모형 천식모델에서 dehydroepiandrosterone 효과장안수대한천식알레르기학회 · 천식 및 알레르기2004 · 제24권 제1호실험 생쥐에서 BCG백신과 DHEA복합 투여의 천식 발생 예방효과최용, 고영아, 최인선대한천식알레르기학회 · 천식 및 알레르기2005 · 제25권 제4호난백알부민 유발 마우스 천식모델에서 Dexamethasone의 기도과민성과 기도 염증에 미치는 영향이동근대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2003 · 제13권 제3호감작된 BALB/c 생쥐에서 Schultz-Dale 반응과 Th2 면역반응에 대한 Dehydroepiandrosterone의 효과최용, 고영아, 원영호, 조용범, 최인선대한천식알레르기학회 · 천식 및 알레르기2008 · 제28권 제2호Pimecrolimus가 마우스 천식 모델에서 기도 염증과 과민성에 미치는 영향권남희, 민태훈, 오미정, 이병재, 이진영, 장현진, 최동철대한천식알레르기학회 · 천식 및 알레르기2005 · 제25권 제3호BALB/c 마우스에서 Ovalbumin으로 유발된 아토피피부염 양 병변에 Dehydroepiandrosterone의 경구투여가 미치는 영향김성진, 원영호, 원준호, 최인선대한천식알레르기학회 · 천식 및 알레르기2009 · 제29권 제4호

이 간행물의 다른 논문 (13건)

알레르기비염 환자에서 집먼지진드기와 쑥화분에 대한 MAST, 피부단자시험 및비유발시험간의 연관성에 관한 연구김경태, 최윤석, 장태영pp. 11-115비알레르기성 천식의 병인기전: 자가면역 가설을 중심으로남동호, 장안수pp. 69-74동물모형 천식모델에서 dehydroepiandrosterone 효과장안수pp. 75-76골뱅이(Buccinum undatum) 알레르기: 감작률과 다른 음식물 항원과의 연관성민경업, 서창희, 이재영, 윤성호, 최정희, 서유진, 김윤근, 박해심, 남동호pp. 77-84천명이 있으면서 정상 폐환기 기능 성적을 보인 천식 환자의 임상분석정세웅, 고영일, 임호, 최인선pp. 85-93
원문 보기