한국의 소아 아토피 천식에서 Thromboxane A2 수용체(T924C) 유전자다형과 폐기능과의 관련성
Thromboxane A2 Receptor (T924C) Polymorphism is Associated with Lower Pulmonary Function in Korean Children with Asthma
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Abstract
Background: Thromboxane A2 and its receptor (TBXA2R) are involved in the constriction of vascular and respiratory smooth muscle, which may play a role in the thickening and remodeling of the airway. Thromboxane A2 receptor polymorphism was recently found to be associated with asthma. Objective: We evaluated whether thromboxane A2 receptor (T924C) gene polymorphism is associated with the asthma phenotype and pulmonary function in Korean children with atopic asthma. Method: The subjects comprised 240 atopic asthmatic and 106 non-atopic healthy children. Asthma phenotypes and bronchial responsiveness to methacholine were determined by a physician. Thromboxane A2 receptor polymorphism was genotyped using PCR-RFLP assays. Result: The genotype frequency of thromboxane A2 recep-tor polymorphism was not statistically different between atopic asthma and non-atopic healthy controls. In contrast, the FEV1 (%) and FEF25～75% (%) were lower in children with homozygous (CC) and heterozygous (CT) for mutant alleles compared to those with wild type (TT) alleles especially in atopic asthmatic children, whereas there were no differences of those parameters in the normal controls. Conclusion: In Korean children with atopic asthma, a significant association was observed between the thromboxane A2 receptor (T924C) polymorphism and spirometric data such as FEV1 (%) and FEF25～75% (%). These results suggest that thromboxane A2 receptor polymorphism would be a disease- modifying gene in childhood asthma.
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