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소아의 기관지 과민성과 아토피 상태에 따른 형제에서의 빈도

Prevalence of Bronchial Hyperresponsiveness and Atopy in Siblings according to their Probands' Status

김도균|유진호|강희|고영률|유영
대한천식알레르기학회 (The Korean Academy of Asthma, Allergy and Clinical Immunology)|2005.03|천식 및 알레르기|제25권 제1호|pp. 27-33

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참고문헌

주제분류임상병리학

초록

Abstract

Background: It has been established that both bronchial hyperresponsiveness (BHR) and atopy had familial tendency. Objective: The aims of this study were to determine whether siblings' frequency of BHR or atopy depends on their probands' and to investigate the relationship between BHR and atopy in probands and siblings, respectively. Method: We performed methacholine bronchial challenges and skin prick testings in 397 proband-sibling pairs on the same day for each pair. According to the results of probands' BHR (PC20＜16 mg/mL) or atopy, siblings were grouped as Group A1 (siblings of probands with BHR, n=288), Group A2 (siblings of probands without BHR, n=109), Group B1 (siblings of probands with atopy, n=300), and Group B2 (siblings of probands without atopy, n=97). Result: Prevalence of BHR was significantly increased inGroup A1 (n=128, 44.4%) than in Group A2 (n=23, 21.1%) (P＜0.001). Significantly numerous atopy subjects were detected in Group B1 (n=146, 48.7%) than in Group B2 (n=34, 35.1%)(P=0.026). Both probands and siblings with BHR had higher frequencies of atopy than without BHR (probands: 80.6% vs. 62.4%, siblings: 54.3% vs. 39.8%)(P＜0.001). Likewise, atopic subjects had greater numbers of BHR than nonatopic subjects (probands: 77.3% vs. 57.7%, siblings: 45.6% vs. 31.8%)(P＜0.001). Conclusion: The prevalence of BHR or atopy in siblings depended on their probands' status. Moreover BHR and atopy were closely related in each of probands and their siblings. We concluded that BHR and atopy run in proband- sibling pair.

참고문헌 (29)

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