Intestinal Microbiota and the Development of Allergy in Infants
2
조회
0
다운로드
0
인용
0
참고문헌
초록
Abstract
We analyzed fecal microbiota in Japanese infants with or without allergy at 6 months using a culture technique. Determination of allergy was based on clinical symptoms, signs, and skin prick test. There were no differences in frequencies or counts of 13 genera and yeast-like organisms at 6 months of age between allergic and non-allergic infants. Bifidobacterium was dominant in all infants irrespective of the presence or absence of allergy. We next investigated the composition of fecal Bifidobacterium species in allergic and non-allergic infants using Bifidobacterium species-specific or group- specific primers based on 16S rDNA sequences at 1, 3 and 6 months of age. At 1 month of age, allergic infants had a higher prevalence of B. catenulatum than non-allergic infants (60.0% vs. 6.3%, P＜0.01). At 6 months of age, allergic infants had a higher prevalence of B. bifidum than non-allergic infants (70.0% vs. 12.5%, P＜0.01). These differences were not related to feeding methods. Finally, we studied the activity of B. bifidum in comparison with B. adolescentis to induce TNF-α and IL-10 from cord blood mononuclear cells. The results suggest B. bifidum has lower activity to induce both cytokines compared to B. adolescentis, suggesting that colonization of lower cytokine producing Bifidobacterium species or strains may be a risk factor for the development of allergy in infancy. (Korean J Asthma Allergy Clin Immunol 2007;27:220-225)
참고문헌 (18)
- "Influences of microbiota on intestinal imune system development", 69, pp.1046~1051 (1999)
- "Intestinal Microbiota and the Development of Allergy in Japanese Infants 225Medzhitov R Recognition of comensal microflora by tol-like receptors is required for intestinal homeostasis", 118, pp.229~241
- "The intestinal microflora in allergic Estonian and Swedish 2-year-old children", 29, pp.342~346 (1999)
- "Allergy development and the intestinal microflora during the first year of life", 108, pp.516~520 (2001)
- "Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing", 107, pp.129~134 (2001)
- "Characterizing the composition of intestinal microflora as a prospective treatment target in infant allergic disease", 32, pp.1~7 (2001)
- "Aberrant composition of gut microbiota of allergic infants a target of bifidobacterial therapy at weaning?", 51, pp.51~55 (2002)
- "Intestinal microflora at 4 months of age and the development of allergy", 53, pp.121~126 (2004)
- "Comparison of the fecal microflora in rural Japanese and urban Canadians", pp.521~32
- "Influence of major histocompatibility complex on bacterial composition of fecal flora", 69, pp.2372~2377 (2001)
- "Comparison of mucosal and species identification of bifidobacteria isolated from healthy and allergic infants", 30, pp.43~71 (2001)
- "Differences in Bifidobacterium f l o r a c o m p o s i t i o n i n allergic and healthy infants", 108, pp.144~145 (2001)
- "Immediate skin test reactivity to Fod and Drug Administration-aproved standardized extracts", adi(ff ad), pp.766~74
- "Differences in fecal microflora between patients with atopic dermatitis and healthy control subjects", 111, pp.587~591 (2003)
- "Quantitative PCR with 16S rRNA-gene-tar-g e t e d s p e c i e s - s p e c i f i c p r i m e r s f o r a n a l y s i s o f h u m a n i n t e s t i n a l bifidobacteria", 70, pp.167~173 (2004)
- "Effects of administration of bifidobacteria on fecal microflora and clinical symptoms in infants with atopic dermatitis", 52, pp.20~30 (2003)
- "microflora in early infancy: composition and development", 91, pp.48~55 (2003)
- "B i f i d o b a c t e r i al species differentially afect expression of cell surface markers and cytokines of dendritic cells harvested from cord blood", 11, pp.686~901 (2004)