생활양식과 관련된 장내 세균의 차이와 알레르기질환: 역학연구 중심으로
Gut Microflora, Lifestyles and Allergic Diseases: The Epidemiological Evidence
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
The current evidence supports a role of gut colonization in promoting and maintaining a balanced immune response during early life. Increasingly, epidemiologic and clinical data support the hypothesis that perturbation in the gastrointestinal microflora due to antibiotic use and dietary differences in ‘industrialized’ countries disrupt normal microflora-mediated immunological tolerance in the mucosa, leading to an increase in the prevalence of allergic diseases. However, there has not been fully adequate longitudinal study of the relation between the infant gut microflora, the development of allergic diseases and the changes of lifestyles. The consensus of opinion is currently still lacking. However, a complex interplay among a host’s immune response,characteristics of the gut microflora, a genetic background and the range of exposures become apparent. Even if at this time, practical implications cannot be deduced directly from these findings, there is a high potential for the development of novel preventive and therapeutic strategies in the future based on the concept of the microflora hypothesis.
Abstract
The current evidence supports a role of gut colonization in promoting and maintaining a balanced immune response during early life. Increasingly, epidemiologic and clinical data support the hypothesis that perturbation in the gastrointestinal microflora due to antibiotic use and dietary differences in ‘industrialized’ countries disrupt normal microflora-mediated immunological tolerance in the mucosa, leading to an increase in the prevalence of allergic diseases. However, there has not been fully adequate longitudinal study of the relation between the infant gut microflora, the development of allergic diseases and the changes of lifestyles. The consensus of opinion is currently still lacking. However, a complex interplay among a host’s immune response,characteristics of the gut microflora, a genetic background and the range of exposures become apparent. Even if at this time, practical implications cannot be deduced directly from these findings, there is a high potential for the development of novel preventive and therapeutic strategies in the future based on the concept of the microflora hypothesis.
참고문헌 (58)
- Strachan DP, "Hay fever, hygiene, and household size", BMJ, 299, pp.1259~1260 (1989)
- Matricardi PM, "Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus", BMJ, 314, pp.999~1003 (1997)
- Shirakawa T, "The inverse association between tuberculin responses and atopic disorder", Science, 275, pp.77~79 (1997)
- Shim JY, "Effects of early measles on later rhinitis and bronchial hyperresponsiveness", ANNALS OF ALLERGY ASTHMA IMMUNOLOGY, 105(1), pp.43~49 (2010), ELSEVIER SCIENCE INC
- Schram D, "Bacterial and fungal components in house dust of farm children, Rudolf Steiner school children and reference children--the PARSIFAL Study", Allergy, 60, pp.611~618 (2005)
- Ege MJ, "Exposure to environmental microorganisms and childhood asthma", N Engl J Med, 364, pp.701~709 (2011)
- Kalliomäki M, "Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing", J Allergy Clin Immunol, 107, pp.129~134 (2001)
- Noverr MC, "The ‘microflora hypothesis’ of allergic diseases", Clin Exp Allergy, 35, pp.1511~1520 (2005)
- Shroff KE, "Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut", Immun, 63, pp.3904~3913 (1995)
- Moreau MC, "Increase in the population of duodenal immunoglobulin A plasmocytes in axenic mice associated with different living or dead bacterial strains of intestinal origin", Infect Immun, 21, pp.532~539 (1978)
- Mazmanian SK, "The love-hate relationship between bacterial polysaccharides and the host immune system", Nat Rev Immunol, 6, pp.849~858 (2006)
- von der Weid T, "Induction by a lactic acid bacterium of a population of CD4(+) T cells with low proliferative capacity that produce transforming growth factor beta and interleukin-10", Clin Diagn Lab Immunol, 8, pp.695~701 (2001)
- Bezirtzoglou E, "The intestinal microflora during the first weeks of life", Anaerobe, 3, pp.173~177 (1997)
- Ly NP, "Mode of delivery and cord blood cytokines: a birth cohort study", Clin Mol Allergy, 4, pp.13~ (2006)
- 이용주, "분만 방법이 소아 레르기질환의 유병률에 미치는 영향", 대한소아알레르기및호흡기학회지, 21(3), pp.197~206 (2011), 대한 소아알레르기 호흡기학회
- Roduit C, "Asthma at 8 years of age in children born by caesarean section", Thorax, 64, pp.107~113 (2009)
- Menezes AM, "Caesarean sections and risk of wheezing in childhood and adolescence: data from two birth cohort studies in Brazil", Clin Exp Allergy, 41, pp.218~223 (2011)
- Rastall RA, "Bacteria in the gut: friends and foes and how to alter the balance", J Nutr, 134(8 Suppl), pp.2022S~2026S (2004)
- Penders J, "Factors influencing the composition of the intestinal microbiota in early infancy", Pediatrics, 118, pp.511~521 (2006)
- Adlerberth I, "Gut microbiota and development of atopic eczema in 3 European birth cohorts", J Allergy Clin Immunol, 120, pp.343~350 (2007)
- Kim KH, "Isolation of Clostridium difficile from the environment and contacts of patients with antibiotic-associated colitis", J Infect Dis, 143, pp.42~50 (1981)
- Penders J, "Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study", Gut, 56, pp.661~667 (2007)
- Giwercman C, "Increased risk of eczema but reduced risk of early wheezy disorder from exclusive breast-feeding in high-risk infants", J Allergy Clin Immunol, 125, pp.866~871 (2010)
- Kull I, "Breast-feeding in relation to asthma, lung function, and sensitization in young schoolchildren", J Allergy Clin Immunol, 125, pp.1013~1019 (2010)
- Kramer MS, "Effect of prolonged and exclusive breast feeding on risk of allergy and asthma: cluster randomised trial", BMJ, 335, pp.815~ (2007)
- Snijders BE, "Breastfeeding and infant eczema in the first year of life in the KOALA birth cohort study: a risk period-specific analysis", Pediatrics, 119, pp.e137~e141 (2007)
- Sears MR, "Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study", Lancet, 360, pp.901~907 (2002)
- Bezirtzoglou E, "Microbiota profile in feces of breast- and formula-fed newborns by using fluorescence in situ hybridization (FISH)", Anaerobe (2011)
- Adlerberth I, "Establishment of the gut microbiota in Western infants", Acta Paediatr, 98, pp.229~238 (2009)
- Coppa GV, "The first prebiotics in humans: human milk oligosaccharides", J Clin Gastroenterol, 38(6 Suppl), pp.S80~S83 (2004)
- Rinne MM, "Similar bifidogenic effects of prebioticsupplemented partially hydrolyzed infant formula and breastfeeding on infant gut microbiota", FEMS Immunol Med Microbiol, 43, pp.59~65 (2005)
- McCaig LF, "Trends in antimicrobial prescribing rates for children and adolescents", JAMA, 287, pp.3096~3102 (2002)
- Alm B, "Neonatal antibiotic treatment is a risk factor for early wheezing", Pediatrics, 121, pp.697~702 (2008)
- Kozyrskyj AL, "Increased risk of childhood asthma from antibiotic use in early life", Chest, 131, pp.1753~1759 (2007)
- Celedón JC, "Lack of association between antibiotic use in the first year of life and asthma, allergic rhinitis, or eczema at age 5 years", Am J Respir Crit Care Med, 166, pp.72~75 (2002)
- Kummeling I, "Early life exposure to antibiotics and the subsequent development of eczema, wheeze, and allergic sensitization in the first 2 years of life: the KOALA Birth Cohort Study", Pediatrics, 119, pp.e225~e231 (2007)
- Dom S, "Pre- and post-natal exposure to antibiotics and the development of eczema, recurrent wheezing and atopic sensitization in children up to the age of 4 years", Clin Exp Allergy, 40, pp.1378~1387 (2010)
- Wickens K, "The association of early life exposure to antibiotics and the development of asthma, eczema and atopy in a birth cohort: confounding or causality", Clin Exp Allergy, 38, pp.1318~1324 (2008)
- Savino F, "Faecal microbiota in breast-fed infants after antibiotic therapy", Acta Paediatr, 100, pp.75~78 (2011)
- Mangin I, "Amoxicillin treatment modifies the composition of Bifidobacterium species in infant intestinal microbiota", Anaerobe, 16, pp.433~438 (2010)
- Ohfuji S, "Sibship size and prevalence of allergic disorders in Japan: the Ryukyus Child Health Study", Pediatr Allergy Immunol, 20, pp.377~384 (2009)
- Martinez FD, "Role of microbial burden in aetiology of allergy and asthma", Lancet, 354(Suppl 2), pp.SII12~SII15 (1999)
- Karmaus W, "Does a higher number of siblings protect against the development of allergy and asthma? A review", J Epidemiol Community Health, 56, pp.209~217 (2002)
- Bernsen RM, "Birth order and sibship size as independent risk factors for asthma, allergy, and eczema", Pediatr Allergy Immunol, 14, pp.464~469 (2003)
- Shore SA, "Obesity and asthma", Pharmacol Ther, 110, pp.83~102 (2006)
- Beuther DA, "Obesity and asthma", Am J Respir Crit Care Med, 174, pp.112~119 (2006)
- Lucas SR, "Paediatric asthma and obesity", Paediatr Respir Rev, 7, pp.233~238 (2006)
- 현동훈, "Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma", FREE RADICAL BIOLOGY AND MEDICINE, 42(5), pp.665~674, ELSEVIER SCIENCE INC
- Appleton SL, "Central obesity is associated with nonatopic but not atopic asthma in a representative population sample", J Allergy Clin Immunol, 118, pp.1284~1291 (2006)
- Chen Y, "The association between obesity and asthma is stronger in nonallergic than allergic adults", Chest, 130, pp.890~895 (2006)
- Ley RE, "Microbial ecology: human gut microbes associated with obesity", Nature, 444, pp.1022~1023 (2006)
- Kalliomäki M, "Early differences in fecal microbiota composition in children may predict overweight", Am J Clin Nutr, 87, pp.534~538 (2008)
- Brehm JM, "Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica", Am J Respir Crit Care Med, 179, pp.765~771 (2009)
- Parikh SJ, "The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults", J Clin Endocrinol Metab, 89, pp.1196~1199 (2004)
- Mai V, "Associations between dietary habits and body mass index with gut microbiota composition and fecal water genotoxicity: an observational study in African American and Caucasian American volunteers", Nutr J, 8, pp.49~ (2009)
- Adorini L, "Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists", Hum Immunol, 70, pp.345~352 (2009)
- Yu S, "Failure of T cell homing, reduced CD4", CD8alphaalpha intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice, 2008, pp.105, 20834~20839
- Wu S, "Vitamin D receptor negatively regulates bacterial-stimulated NF-kappaB activity in intestine", Am J Pathol, 177, pp.686~697 (2010)
