수도권 학령전기 소아에서 식품알레르기의 유병률 및 위험인자
Prevalence and Risk Factors of Food Allergy in Preschool Children in Seoul
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초록
Background: The aim of this study was to investigate the prevalence of food allergy (FA) and determine its risk factors in the preschool urban children in Seoul, Korea. Methods: A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 933 pre-school children from nine urban areas of Seoul in Korea. The risk factor analysis was done by logistic regression analysis. Results: In preschool children, the lifetime and recent 12-month prevalence of FA symptoms were 21.0% and 10.6%,respectively. The lifetime prevalence of FA diagnosis was 6.1%, the prevalence of current FA (12-month symptoms and diagnosis) was 3.3%, and the recent 12-month prevalence of FA treatment was 3.6%. Blood eosinophils [0] in FA group and Non-FA group were 5.00±3.93% and 3.93±2.91%,respectively (P=0.002). The median total Immunoglobulin E (IgE) of FA group was 102 (interquatile [IQ] range 44.8∼257) IU/mL, the median total IgE of Non-FA group was 70.9 (IQ range 70.9∼161) IU/mL (P=0.001). Parental FA (adjusted odds ratio [aOR], 2.17; 95% confidence interval [CI], 1.22∼3.85), past history of AD diagnosis (aOR, 3.69;95% CI, 2.33∼5.85), eczema on doctor’s physical examination (aOR, 3.74; 95% CI, 2.16∼6.47), use of antibiotics during infancy more than 3 days (aOR, 1.72; 95% CI, 1.08∼2.73) were the independent risk factors for FA symptoms within 12 months. Conclusion: In preschool urban children in Seoul, the lifetime prevalence of FA diagnosis was 6.1%, the recent 12month prevalence of FA treatment was 3.6%. The prevalences of AD and doctor examined AD in FA group were significantly higher compared to Non-FA group. Family history,and the use of antibiotics during infancy could be the independent risk factors for the development of FA.
Abstract
Background: The aim of this study was to investigate the prevalence of food allergy (FA) and determine its risk factors in the preschool urban children in Seoul, Korea. Methods: A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 933 pre-school children from nine urban areas of Seoul in Korea. The risk factor analysis was done by logistic regression analysis. Results: In preschool children, the lifetime and recent 12-month prevalence of FA symptoms were 21.0% and 10.6%,respectively. The lifetime prevalence of FA diagnosis was 6.1%, the prevalence of current FA (12-month symptoms and diagnosis) was 3.3%, and the recent 12-month prevalence of FA treatment was 3.6%. Blood eosinophils [0] in FA group and Non-FA group were 5.00±3.93% and 3.93±2.91%,respectively (P=0.002). The median total Immunoglobulin E (IgE) of FA group was 102 (interquatile [IQ] range 44.8∼257) IU/mL, the median total IgE of Non-FA group was 70.9 (IQ range 70.9∼161) IU/mL (P=0.001). Parental FA (adjusted odds ratio [aOR], 2.17; 95% confidence interval [CI], 1.22∼3.85), past history of AD diagnosis (aOR, 3.69;95% CI, 2.33∼5.85), eczema on doctor’s physical examination (aOR, 3.74; 95% CI, 2.16∼6.47), use of antibiotics during infancy more than 3 days (aOR, 1.72; 95% CI, 1.08∼2.73) were the independent risk factors for FA symptoms within 12 months. Conclusion: In preschool urban children in Seoul, the lifetime prevalence of FA diagnosis was 6.1%, the recent 12month prevalence of FA treatment was 3.6%. The prevalences of AD and doctor examined AD in FA group were significantly higher compared to Non-FA group. Family history,and the use of antibiotics during infancy could be the independent risk factors for the development of FA.
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