중심장액맥락망막병증에서 다른 눈의 중심와아래 맥락막 두께
Subfoveal Choroidal Thickness in Fellow Eyes of Patients with Central Serous Chorioretinopathy
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목적: 중심장액맥락망막병증(CSC)에서 스펙트럼 도메인 빛간섭단층촬영의 Enhanced Depth Imaging (EDI-OCT)을 이용하여 이환되지 않은 눈의 중심와아래 맥락막 두께를 알아보고자 하였다. 대상과 방법: CSC환자 30명, 정상 28명을 대상으로 양안의 중심와아래 맥락막 두께를 측정하여 비교하였다. 인도시아닌그린 형광안저혈관조영술(ICGA)을 시행하여 맥락막 과투과 부위를 조사하여 맥락막 과투과가 있는 경우와 없는 경우를 분석하였다. 결과: CSC에 이환된 눈의 맥락막 두께 평균은 439.6 μm로, 다른 눈 340.0 μm에 비해 통계적으로 유의하게 두꺼웠다. 두 군 모두정상안 266.5 μm와 비교하여 유의한 차이가 있었다. 다른 눈의 맥락막 두께는 맥락막 과투과가 있는 경우 370.0 μm로, 없는 경우220.5 μm에 비하여 증가되어 있었다. 급성 및 만성 CSC의 맥락막 두께는 441.6 μm, 454 μm로 유의한 차이가 없었다. 결론: 단안 CSC 환자에서 이환되지 않은 다른 눈의 중심와아래 맥락막 두께는 맥락막 과투과가 있는 경우 증가되어 있다. EDI-OCT를이용하여 맥락막 두께를 비침습적으로 측정함으로써 맥락막 과투과의 영향을 평가할 수 있다.
Abstract
Purpose: To determine the relationship between subfoveal choroidal thickness of fellow eyes and choroidal vascular hyperpermeability in unilateral central serous chorioretinopathy (CSC). Methods: Thirty patients with unilateral CSC and 28 normal subjects underwent enhanced depth imaging spectral-domain optical coherence tomography to evaluate bilateral subfoveal choroidal thickness. The subfoveal choroidal thickness was measured from the outer RPE border to the inner sclera border. Choroidal vascular hyperpermeability was visualized with indocyanine green angiography (ICGA) and analyzed. Results: The mean subfoveal choroidal thickness in the affected eyes (439.6 ± 136.5 μm) was significantly thicker than that in fellow eyes (340.0 ± 103.3 μm, p = 0.002), and both showed statistically significant difference compared with normal subjects (266.5 ± 111.5 μm, p < 0.001, p = 0.019). The subfoveal choroidal thickness of fellow eyes with choroidal vascular hyperpermeability was 370.0 ± 176.5 μm, which differed significantly (p = 0.037) from the choroid without choroidal vascular hyperpermeability. The choroidal thickness of acute CSC was 441.6 ± 118.6 μm, and that of chronic CSC was 454 ±166.5 μm, a difference that was not statistically significant (p = 0.676). Conclusions: The subfoveal choroid with hyperpermeability was thicker than that without hyperpermeability on ICGA in the fellow eyes of patients with unilateral CSC. Enhanced depth imaging spectral-domain optical coherence tomography can indirectly evaluate the effects of choroidal hyperpermeability by noninvasively measuring the choroidal thickness.
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