중심장액맥락망막병증 환자의 이환된 눈과 무증상 반대편 눈, 정상 대조군과의 맥락막두께 비교
Comparison of Choroidal Thickness in Eyes with Central Serous Chorioretinopathy, Asymptomatic Fellow Eyes and Normal Eyes
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초록
목적: 스펙트럼 도메인 빛간섭단층촬영(SD-OCT)을 이용하여 중심장액맥락망막병증(CSC) 환자와 정상대조군에서 황반하 맥락막 두께를 측정하고, 이를 비교 분석하고자 하였다. 대상과 방법: CSC가 이환된 눈과 무증상 반대편눈, 정상안 사이의 맥락막 두께를 비교하였다. 맥락막 두께와 연관된 인자로 나이, 장액성망막박리 높이, 굴절력과의 상관관계를 알아보았다. 맥락막 두께는 황반하 망막색소상피의 외측경계에서부터 공막의 내측경계까지수직선을 그어 길이를 측정하였다. 결과: CSC 환자 25명 25안과 반대편 눈 17안, 같은 연령의 정상대조군 29명 29안을 각각 1군, 2군, 3군으로 하였다. 평균 맥락막 두께는 1군 370.64 ± 58.06 μm, 2군 301.85 ± 47.83 μm, 3군 261.84 ± 48.22 μm으로, 1군은 2군과 3군보다, 2군은 3군보다 유의하게두꺼웠다(p=0.001, p＜0.001, p=0.004). 3군에서만 나이가 증가함에 따라 맥락막 두께가 유의하게 감소하였다(p=0.015). 결론: CSC가 이환된 눈과 반대편 눈에서 맥락막 두께가 정상안에 비해 두꺼운 것을 확인하였으며, 이는 맥락막모세혈관의 과투과 및맥락막내 정수압 증가를 시사한다.
Abstract
Purpose: To compare the choroidal thickness in central serous chorioretiopathy (CSC) patients and normal controls using spectral domain optical coherence tomography (SD-OCT). Methods: The authors compared the choroidal thickness in eyes with CSC, fellow eyes and in normal eyes. In addition, the authors attempted to determine any correlation between choroidal thickness and other factors such as age, height of serous retinal detachment, and spherical equivalent. Choroidal thickness was measured using a perpendicular line from the outer margin of the subfoveal retinal pigment epithelium to the inner surface of the sclera. Results: Twenty-five eyes of 25 CSC patients, 17 fellow eyes and 29 age-matched normal eyes were examined and categorized as group 1, group 2 and group 3, respectively. Subfoveal choroidal thickness was 370.64 ± 58.06 μm in group 1,301.85 ± 47.83 μm in group 2, and 261.84 ± 48.22 μm in group 3. The choroidal thickness in group 1 was significantly greater than those in group 2 and group 3, and the choroidal thickness in group 2 was significantly greater than that in group 3 (p = 0.001, p < 0.001, p = 0.004, respectively), where the choroidal thickness showed a negative correlation with age (p = 0.015). Conclusions: The choroidal thickness was greater in eyes with CSC and in their fellow eyes compared to that in normal eyes. The results suggest that CSC may be caused by choroidal vascular hyperpermeability and increased hydrostatic pressure in the choroid.
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