중심장액맥락망막병증 환자의 무증상 반대쪽 눈의 스펙트럼 도메인 빛간섭단층촬영 소견
Spectral Domain OCT Findings of Asymptomatic Fellow Eyes in Central Serous Chorioretinopathy
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목적: 스펙트럼 도메인 빛간섭단층촬영(SD OCT)을 이용하여 중심장액맥락망막병증 환자의 무증상 반대쪽 눈의 형태학적 변화에 대해 알아보고자 하였다. 대상과 방법: 급성 중심장액맥락망막병증 환자 55명의 무증상 반대쪽 눈 55안을 대상으로 SD OCT, 형광안저혈관조영술(FA) 및 인도 사이아닌그린혈관조영술(ICGA)을 시행하여 그 결과를 분석하였다. 결과: FA에서 정상인 16안(29.1%)은 SD OCT에서도 정상이었으나, 이 중 70%는 ICGA에서 맥락막과투과 또는 과형광점이 관찰되었다. FA에서 창문비침은 25안(45.5%)에서 관찰되었으며 SD OCT에서 망막색소상피의 주름 또는 융기 모양을 보였다. FA에서 망막색소상 피박리는 6안(10.9%)에서 관찰되었으며 SD OCT에서도 같은 변화를 보였다. FA에서 누출점은 10안(18.2%)에서 관찰되었으며 SD OCT 에서 정상 또는 장액망막박리, 망막색소상피의 주름 또는 융기 모양을 보였다. 결론: 급성 중심장액맥락망막병증 환자의 무증상 반대쪽 눈에서 관찰된 SD OCT 소견을 통해 중심장액맥락망막병증의 형태학적 변화 및 병태생리에 대해 많은 정보를 얻을 수 있었다.
Abstract
Purpose: To investigate morphologic changes in the asymptomatic fellow eye of central serous chorioretinopathy (CSC) using spectral domain optical coherence tomography (SD OCT). Methods: The present retrospective study included 55 asymptomatic fellow eyes of 55 patients with acute CSC. All patients underwent SD OCT, fluorescein angiography (FA), and indocyanine green angiography (ICGA), and the results were analyzed. Results: Sixteen eyes (29.1%) with normal FA also showed normal SD OCT; however, 70% of the eyes showed choroidal hyperpermeability or punctate hyperfluorescent spots on ICGA. Window defects on FA were observed in 25 eyes (45.5 %), and they were represented as a corrugation or bump in the retinal pigment epithelium (RPE) on SD OCT. Retinal pigment epithelial detachments (PEDs) were observed in six eyes (10.9 %) on FA and were represented as PEDs on SD OCT. Leakages on FA were observed in ten eyes (18.2%) and were represented as normal, serous retinal detachment, and a corrugation or bump of RPE on SD OCT. Conclusions: Greater information regarding morphologic changes and pathophysiology of CSC can be obtained by investigating SD OCT findings in the asymptomatic fellow eyes of acute CSC.
참고문헌 (24)
- Gass JD, "Pathogenesis of disciform detachment of the neuroepithelium", Am J Ophthalmol, 63, pp.1~139 (1967)
- Guyer DR, "Digital indocyanine green videoangiography of central serous chorioretinopathy", Arch Ophthalmol, 112, pp.1057~1062 (1994)
- Spaide RF, "Central serous chorioretinopathy in younger and older adults", Ophthalmology, 103, pp.2070~2079 (1996)
- Alam S, "Clinical application of rapid serial fourier-domain optical coherence tomography for macular imaging", Ophthalmology, 113, pp.1425~1431 (2006)
- Chen TC, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging", Arch Ophthalmol, 123, pp.1715~1720 (2005)
- Hangai M, "Three-dimensional imaging of macular holes with high-speed optical coherence tomography", Ophthalmology, 114, pp.763~773 (2007)
- Ojima Y, "Three-dimensional imaging of the foveal photoreceptor layer in central serous chorioretinopathy using high-speed optical coherence tomography", Ophthalmology, 114, pp.2197~2207 (2007)
- Wojtkowski M, "Ophthalmic imaging by spectral optical coherence tomography", Am J Ophthalmol, 138, pp.412~419 (2004)
- Wojtkowski M, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography", Ophthalmology, 112, pp.1734~1746 (2005)
- Wolf-Schnurrbusch UE, "Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination", Invest Ophthalmol Vis Sci, 49, pp.3095~3099 (2008)
- Habib MS, "The combination of intravitreal triamcinolone and phacoemulsification surgery in patients with diabetic foveal oedema and cataract", BMC Ophthalmol, 5, pp.15~ (2005)
- Gelber GS, "Loss of vision due to central serous chorioretinopathy following psychological stress", Am J Psychiatry, 144, pp.46~50 (1987)
- Yannuzzi LA, "Type-A behavior and central serous chorioretinopathy", Retina, 7, pp.111~131 (1987)
- Horniker E, "Ueber eine Form von zentraler Retinitis auf angio-neurotischer Grundlage (Retinitis centralis angio-neurotica)", Graefes Arch Clin Exp Ophthalmol, 123, pp.286~360 (1929)
- Garg SP, "Endogenous cortisol profile in patients with central serous chorioretinopathy", Br J Ophthalmol, 81, pp.962~964 (1997)
- Bouzas EA, "Central serous chorioretinopathy in endogenous hypercortisolism", Arch Ophthalmol, 111, pp.1229~1233 (1993)
- Haimovici R, "Risk factors for central serous chorioretinopathy: a case-control study", Ophthalmology, 111, pp.244~249 (2004)
- Gass JD, "Bilateral bullous exudative retinal detachment complicating idiopathic central serous chorioretinopathy during systemic corticosteroid therapy", Ophthalmology, 102, pp.737~747 (1995)
- Friberg TR, "Serous retinal detachment resembling central serous chorioretinopathy following organ transplantation", Graefes Arch Clin Exp Ophthalmol, 228, pp.305~309 (1990)
- Tittl MK, "Systemic findings associated with central serous chorioretinopathy", Am J Ophthalmol, 128, pp.63~68 (1999)
- Yoshioka H, "Fluorescein angiographic findings in experimental retinopathy produced by intravenous adrenaline injection. Preliminary report", Nippon Ganka Kiyo, 21, pp.648~652 (1970)
- Chrousos GP, "The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis", JAMA, 267, pp.1244~1252 (1992)
- Lin JM, "Retinal pigment epithelial detachment in the fellow eye of a patient with unilateral central serous chorioretinopathy treated with steroid", Retina, 21, pp.377~379 (2001)
- Marmor MF, "Central serous chorioretinopathy: bilateral multifocal electroretinographic abnormalities", Arch Ophthalmol, 117, pp.184~188 (1999)