본문 바로가기
KERD
논문KCI 등재

외상성 뇌손상 환자의 SPECT 영상 판독 결과와 통계적 파라미터 지도 분석 결과와의 비교 연구

A Comparison Study between Visual Interpretation and Statistical Parametric Mapping Analysis of Single Photon Emission Computed Tomography Images in Traumatic Brain Injury Patients

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류정신과학

초록

ObjectivesZZThe first objective of this study was to examine the extent to which the results of the visual interpretation of brain single photon emission computed tomography (SPECT) images correspond with those of SPM analysis in patients with traumatic brain injury (TBI). The second objective was to explore the possibility of the clinical application of SPM analysis for finding the brain lesions related to the neuropsychiatric symptoms, of which the patients complained. MethodsZZSPECT images from 10 TBI patients (all male, mean age: 46.8±12.32) and 10 age- and sex-matched control subjects were interpreted by an experienced radiologist. Their SPECT images were also analyzed by SPM2 software for comparing the individual images with the controls. ResultsZZThe results of visual interpretation of SPECT images generally corresponded with those of SPM analysis in five of the 10 TBI cases. In the remaining cases, brain lesions not identified from visual interpretation were found through SPM analysis. The location of these lesions included the anterior cingulate gyrus, caudate nucleus, thalamus, and subcallosal gyrus. SPM analysis also made it easy to find brain hypoperfusion areas associated with the TBI patients’ neuropsychiatric symptoms. ConclusionZZThis study suggested possible clinical applications of SPM analysis of SPECT data from patients with TBI. Its advantages and limitations were discussed.

Abstract

ObjectivesZZThe first objective of this study was to examine the extent to which the results of the visual interpretation of brain single photon emission computed tomography (SPECT) images correspond with those of SPM analysis in patients with traumatic brain injury (TBI). The second objective was to explore the possibility of the clinical application of SPM analysis for finding the brain lesions related to the neuropsychiatric symptoms, of which the patients complained. MethodsZZSPECT images from 10 TBI patients (all male, mean age: 46.8±12.32) and 10 age- and sex-matched control subjects were interpreted by an experienced radiologist. Their SPECT images were also analyzed by SPM2 software for comparing the individual images with the controls. ResultsZZThe results of visual interpretation of SPECT images generally corresponded with those of SPM analysis in five of the 10 TBI cases. In the remaining cases, brain lesions not identified from visual interpretation were found through SPM analysis. The location of these lesions included the anterior cingulate gyrus, caudate nucleus, thalamus, and subcallosal gyrus. SPM analysis also made it easy to find brain hypoperfusion areas associated with the TBI patients’ neuropsychiatric symptoms. ConclusionZZThis study suggested possible clinical applications of SPM analysis of SPECT data from patients with TBI. Its advantages and limitations were discussed.

참고문헌 (26)

  1. Levin HS, "Neurobehavioral outcome 1 year after severe head injury. Experience of the Traumatic Come Data Bank", J Neurosurg, 73, pp.699~709 (1990)
  2. Kim BC, "Clinical characteristics of the casualties referred from the court for mental disability evaluation after traffic accident", J Korean Neuropsychiatr Assoc, 38, pp.318~329 (1998)
  3. Newberg AB, "Neuroimaging in patients with head injury", Semin Nucl Med, 33, pp.136~147 (2003)
  4. Ichise M, "Technetium-99m-HMPAO SPECT, CT and MRI in the evaluation of patients with chronic traumatic brain injury: a correlation with neuropsychological performance", J Nucl Med, 35, pp.217~226 (1994)
  5. Frinston RJ, "Statistical parametric mapping: In functional Neuroimaging" (1994), Academic Press
  6. Stamatakis EA, "Validation of statistical parametric mapping (SPM) in assessing cerebral lesions: A simulation study", Neuroimage, 10, pp.397~407 (1999)
  7. Shin YB, "Voxelbased statistical analysis of cerebral blood flow using Tc-99m ECD brain SPECT in patients with traumatic brain injury: group and individual analyses", Brain Inj, 20, pp.661~667 (2006)
  8. Bonne O, "Cerebral blood flow in chronic symptomatic mild traumatic brain injury", Psychiatr Res Neuroimaging, 124, pp.141~152 (2003)
  9. Kim NH, "Reduced regional cerebral blood flow in patients with traumatic brain injury who had no structural abnormalities on magnetic resonance imaging", 생물정신의학, 9, pp.152~158 (2002)
  10. Stamatakis EA, "SPECT imaging in head injury interpreted with statistical parametric mapping", J Nucl Med, 43, pp.476~483 (2002)
  11. Laatsch L, "Incorporation of SPECT imaging in a longitudinal cognitive rehabilitation therapy programme", Brain Inj, 13, pp.555~570 (1999)
  12. Kim J, "Korean MMPI-2 user manual" (2005), Maumsarang
  13. Yeom TH, "Practical Application of K-WAIS" (1992), Korea Guidance
  14. Jeong Y, "18F-FDG PET findings in frontotemporal dementia: an SPM analysis of 29 patients", J Nucl Med, 46, pp.233~239 (2005)
  15. Shin YB, "Voxelbased statistical analysis of cerebral blood flow using Tc-99m ECD brain. SPECT in patients with traumatic brain injury: group and individual analyses", Brain Inj, 20, pp.661~667 (2006)
  16. Nakayama N, "Relationship between regional cerebral metabolism and consciousness disturbance in traumatic diffuse brain injury without large focal lesions: an FDGPET study with statistical parametric mapping analysis", J Neurol Neurosurg Psychiatry, 77, pp.856~862 (2006)
  17. Carmichael ST, "Evolution of diaschisis in a focal stroke model", Stroke, 35, pp.758~763 (2004)
  18. Clark DL, "The brain and behavior: an introduction to behavioral neuroanatomy", pp.35~52 (2005), Cambridge University Press
  19. Hillis AE, "Anatomy of spatial attention: insights from perfusion imaging and hemispatial neglect in acute stroke", J Neurosci, 25, pp.3161~3167 (2005)
  20. Granacher RP, "Traumatic brain injury: methods for clinical and forensic neuropsychiatri assessment", pp.36~37 (2003), CRC press LLC
  21. Levitin DJ, "Musical structure is processed in “language” area of the brain: a possible role for Brodmann Area 47 in temporal coherence", Neuroimage, 20, pp.2142~2152 (2003)
  22. Granacher RP, "Traumatic brain injury: methods for clinical and forensic neuropsychiatric assessment", pp.181~182 (2003), CRC press LLC
  23. Stuart CY, "The American Psychiatric Publishing textbook of neuropsychiatry and behavioral neurosciences", pp.46~48 (2008), American psychiatric publishing, Inc
  24. Shin LM, "Amygdala, medial prefrontal cortex, and hippocampal function in PTSD", Annu N Y Acad Sci, 1071, pp.67~79 (2006)
  25. Nagano AS, "Extrastriatal mean regional uptake of fluorine-18-FDOPA in the normal aged brain--an approach using MRI-aided spatial normalization", Neuroimage, 11, pp.760~766 (2000)
  26. Gispert JD, "Influence of the normalization template on the outcome of statistical parametric mapping of PET scans", Neuroimage, 19, pp.601~612 (2003)

관련 논문AI추천

외상성 뇌손상 환자에서 SPECT 상 전두엽 뇌혈류 변화와 실행기능 간의 상관관계강도영, 김성환, 박재홍, 서상민, 이문숙, 최병무대한생물치료정신의학회 · 생물치료정신의학2010 · 제16권 제2호원발성 정상압수두증 환자의 국소 뇌혈류 변화 : Statistical Parametric Mapping을 이용한 SPECT 분석김범생, 손영민, 손형선, 심용수, 양동원, 윤보라, 정성우, 정용안대한치매학회 · Dementia and Neurocognitive Disorders(대한치매학회지)2007 · 제6권 제1호SPECT 영상을 이용한 경도인지장애 환자의 유형별 국소 뇌혈류 분석강도영, 강지혜, 김상호, 김재우, 박경원, 박지욱, 차재관, 천상명대한치매학회 · Dementia and Neurocognitive Disorders(대한치매학회지)2009 · 제8권 제1호외상성 뇌손상 환자에서 뇌자기공명영상 소견에 따른 정신증상, 신경인지기능 및 삶의 질김수인, 김영철, 김지민, 성유미, 연규월, 임원정대한신경정신의학회 · 신경정신의학2007 · 제46권 제3호기억성 경도인지장애와 초기 알쯔하이머병에서의 국소뇌혈류 변화김범생, 심용수, 양동원, 정용안대한치매학회 · Dementia and Neurocognitive Disorders(대한치매학회지)2007 · 제6권 제2호화소 기반 형태분석 방법을 이용한 알츠하이머 치매환자의 회백질 용적감소의 정량적 분석이철, 백인호, 이창욱, 임현국, 최은형대한생물정신의학회 · 생물정신의학2008 · 제15권 제2호

이 간행물의 다른 논문 (12건)