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경도인지장애를 동반한 파킨슨병과 기억성 경도인지장애의 K-MoCA 인지 영역 비교

Comparison of Cognitive Domains in the Korean Version of Montreal Cognitive Assessment between Parkinson’s Disease with Mild Cognitive Impairment and Amnestic Mild Cognitive Impairment

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초록

본 연구는 Montreal Cognitive Assessment (MoCA)를 이용하여 구한 인지기능(지남력, 주의력, 언어기능, 시구성능력, 기억력 및 집행기능) 지수가 정상 노인, 파킨슨 경도인지장애(Mild Cognitive Impairment in Parkinson’s disease [PD-MCI]) 및 기억성 다영역 경도인지장애(amnestic multiple domain MCI [amMCI]) 환자 간 차이를 나타내는지 확인하고자 수행되었다. 정상 노인 30명, PD-MCI환자 30명 및 amMCI환자 30명이 연구에 참여하였고, 모든 대상자에게 한국판 MoCA를 실시하였다. 집단 간의 MoCA 총점과 인지영역 지수를 비교하기 위해 공변량분석(ANCOVA)을 실시한 결과, PD-MCI환자들은 MoCA의 총점, 기억력 및 집행기능 지수가 정상 노인에 비해 유의하게 낮은 것으로 확인되었다. amMCI환자들은 정상 노인과 비교하였을 때, 총점과 6개의 인지영역 지수가 모두 낮은 것으로 나타났다. 이러한 연구 결과는 MoCA의 총점을 확인하는 것보다 인지영역 지수를 살펴보는 것이 PD-MCI와 amMCI의 인지기능 결함에 대한 더 많은 정보를 제공한다는 것을 시사한다.

Abstract

This study investigated whether the cognitive domain index score (CDIS) obtained by the Montreal Cognitive Assessment (MoCA) showed differences between three groups: Normal elderly, Mild Cognitive Impairment in Parkinson’s disease (PD-MCI), and amnestic multiple domain MCI (amMCI) patients. The cognitive domains assessed included orientation, attention, language, visuospatial function, memory, and executive function. A total of 30 normal elderly, 30 PD-MCI patients, and 30 amMCI patients participated in the study. All participants were administered the Korean-MoCA. Covariance analyses were conducted to identify the group differences. In summary, PD-MCI patients showed significantly lower MoCA total, memory, and executive index scores than the normal elderly. The amMCI patients had a lower MoCA total score and six CDIS than normal elderly. These results suggest that MoCA-CDIS provides more information about the defect of cognitive function in the PD-MCI and the amMCI patients than the MoCA total score.

참고문헌 (35)

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